Models of Protection Against HIV/SIV

用于HIV/AIDS预防和/或免疫治疗的成功疫苗是21世纪的突出挑战之一。迄今为止，所有针对此病毒/疾病的人体疫苗试验均以失败收场，抑或最好只是疗效非常差。致力于HIV/AIDS研究的科学界人士全体一致地提议聚焦于基础科学，希冀发现保护相关因素以指引疫苗制剂研发和评估。但是，自然中似乎已发现一些应对HIV和相关灵长类慢病毒亚属的方法，抑或通过抵抗康然，抑或一旦被感染，避免免疫损伤或免疫缺陷。《抵御HIV/SIV的保护模式》将帮助读者基于近期重要研究深度思考疫苗和治疗研究的思路。本书将由HIV抵抗/保护领域一些众所周知的专家执笔：包括F. Barré-Sinoussi（2008年诺贝尔奖得主）、B. Walker、 S. Rowland-Jones、 A. Telenti、 M. Lederman和F. Plummer。本书结构独特，先分别单独审视三种不同的抵抗/保护模型，之后进行两两比较，以帮助读者细致考察寻找疫苗的最突出研究。该结构以浅显易懂的形式呈现信息，使得本书适合多学科读者——实乃科学界、医疗护理、公共卫生和学术界等领域人士的重要参考书。

A successful vaccine for the prevention and/or immunotherapy against HIV/AIDS is one of the prominent challenges of the 21st century. To date, all human vaccine trials against this virus/disease have resulted in failure, or at best have shown very low efficacy. The scientific community dealing with HIV/AIDS has unanimously proposed a focus on basic science, with the intention of identifying correlates of protection that can serve as guides in developing and evaluating vaccine preparation. However, Nature seems to have already found several ways of dealing with infections by HIV and related primate lentiviruses, either by resisting infection or, once infected, avoiding immune damage and immunodeficiency.
Models of Protection Against HIV/SIV will allow for an in-depth reflection on the perspectives for vaccine and therapy research derived from important recent studies. It will be authored by some of the most well known specialists in the field of HIV resistance/protection: including F. Barré-Sinoussi (2008 Nobel Prize for Medicine winner), B. Walker, S. Rowland-Jones, A. Telenti, M. Lederman and F. Plummer.
This book is structured in a unique way, looking at three models of resistance/protection separately and then comparing the models against one another to provide its readership with a detailed examination of the research that is most predominant in the search for a vaccine. This structure presents the information in an easy-to-understand format and gives the book a cross-discipline appeal -- an important reference for those in the scientific community, medical care, public health and academia alike.