一项比较低通量光动力疗法与玻璃体内注射兰尼单抗治疗慢性中心性浆液性脉络膜视网膜病变(CCSC)的随机初步研究

A Randomized Pilot Study of Low-Fluence Photodynamic Therapy Versus Intravitreal Ranibizumab for Chronic Central Serous Chorioretinopathy
作者:Bae Heo Kim 【View at publisher】
期刊: AM J OPHTHALMOL2011年3月期卷 专家评级: 循证评级:B

Purpose:To report 6-month outcomes of a prospective, randomized study comparing the efficacy and safety between low-fluence photodynamic therapy (PDT) and intravitreal injections of ranibizumab in the treatment of chronic central serous chorioretinopathy. Design:Prospective, randomized, single-center pilot study. Methods:Sixteen eyes with chronic central serous chorioretinopathy were randomized to receive either low-fluence PDT or intravitreal injections of ranibizumab: 8 eyes in the low-fluence PDT group and 8 in the ranibizumab group. Rescue treatment was considered if subretinal fluid was sustained after completion of primary treatment: low-fluence PDT for the ranibizumab group and ranibizumab injection for the low-fluence PDT group. Main outcome measures were excess foveal thickness, resolution of subretinal fluid, choroidal perfusion on indocyanine green angiography, and best-corrected visual acuity. Results:At 3months, the mean excess foveal thickness was reduced from 74.1±56.0μm to −35.4±44.5μm in the low-fluence PDT group (P=.017) and from 26.3±50.6μm to −23.1±56.5μm in the ranibizumab group (P=.058). After a single session of PDT, 6 eyes (75%) in the low-fluence PDT group achieved complete resolution of subretinal fluid and reduction of choroidal hyperpermeability, whereas 2 (25%) eyes in the ranibizumab group achieved this after consecutive ranibizumab injections. Four eyes (50%) in the ranibizumab group underwent additional low-fluence PDT and accomplished complete resolution. At 3months, significant improvement of best-corrected visual acuity was not demonstrated in the low-fluence PDT group (P=.075), whereas it was observed in the ranibizumab group (P=.012). However, the tendency toward improvement of best-corrected visual acuity was not maintained. Conclusions:In terms of anatomic outcomes, the effect of ranibizumab injections was not promising compared with that of low-fluence PDT.

学科代码:眼科学   关键词:一项比较低通量光动力疗法与玻璃体内注射兰尼单抗治疗慢性中心性
顶一下(0
您可能感兴趣的文章
    发表评论网友评论(0)
      发表评论
      登录后方可发表评论,点击此处登录