滔蛋白病转基因模型中磷酸化TDP-43的稳健胞浆蓄积

Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy
作者:Amy K. Clippinger
期刊: ACTA NEUROPATHOL2013年7月1期126卷

Abstract
Frontotemporal lobar degeneration (FTLD) has been subdivided based on the main pathology found in the brains of affected individuals. When the primary pathology is aggregated, hyperphosphorylated tau, the pathological diagnosis is FTLD-tau. When the primary pathology is cytoplasmic and/or nuclear aggregates of phosphorylated TAR-DNA-binding protein (TDP-43), the pathological diagnosis is FTLD-TDP. Notably, TDP-43 pathology can also occur in conjunction with a number of neurodegenerative disorders; however, unknown environmental and genetic factors may regulate this TDP-43 pathology. Using transgenic mouse models of several diseases of the central nervous system, we expl

学科代码:神经病学   关键词:Tau TDP-43 Mouse Transgenic Neurop tauopathy TDP-43 proteinopathi ,全球精选全文 爱思唯尔医学网, Elseviermed
来源: ACTA NEUROPATHOLOGICA
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