氮等离子体浸没离子注入对聚醚醚酮生物活性及抗菌作用的影响

Bioactivity and antibacterial effect of nitrogen plasma immersion ion implantation on polyetheretherketone
2016-12-27 12:53发表评论
作者:Gan, K., Liu, H. , Jiang, L., Liu, X., Song, X., Niu, D., Chen, T., Liu, C.
机构: 吉林大学口腔医学院暨附属口腔医院综合治疗科
期刊: DENT MATER2016年11月11期32卷

Objective We aimed to investigate the bioactivity and antibacterial effect of nitrogen plasma immersion ion implantation (PIII) on polyetheretherketone (PEEK). Methods According to the different modified parameters, the PEEK specimens were randomly divided into four main groups (n = 49/group): PEEK-C, PEEK-I, PEEK-L, and PEEK-H. Then, N2-PIII surface modification was conducted using the corresponding parameters. The microstructure and composition of the modified PEEK surface was observed by scanning electron microscope (SEM), atomic force microscopy (AFM) and X-ray photoelectron spectroscopy (XPS). The water contact angle of the PEEK surface was also studied by contact angle meters. The bioactive ability of PEEK samples was evaluated by observing the attachment, proliferation, and differentiation of MG63 cells cultured on the PEEK samples. Antibacterial property of the samples against Staphylococcus aureus was detected with the plate colony-counting methods. Results SEM and AFM analysis shows that PEEK-C surface is relatively smooth with the Ra value of 50.6 ± 2.52 nm. PEEK-I and PEEK-L surface is rough with the Ra value of 435.9± 6.47 nm and 443.23 ± 5.49 nm, respectively, and the PEEK-H surface is the most rough with the Ra value of 608.4 ± 3.14 nm. XPS element analysis demonstrated that nitrogen functional groups were successfully introduced into the surface of PIII-modified PEEK. Biological evaluation and the antibacterial results showed that nitrogen PIII treatment can significantly improve the biological activity of PEEK, and samples showed antibacterial properties against S. aureus. Significance PEEK surface subjected to the N2-PIII treatment showed better biological activity and antibacterial effect. Therefore, N2-PIII-treated PEEK surface is promising in bone tissue engineering and dental applications. © 2016 The Academy of Dental Materials

 

通讯机构:Department of General Dentistry, School and Hospital of Stomatology, Jilin University, 1500 Qing Hua Road, Changchun, China
学科代码:口腔医学   关键词:氮等离子体 聚醚醚酮生物 ,中国作者重要发表 爱思唯尔医学网, Elseviermed
来源: Scopus
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