山荷叶叶片水溶液治疗糖尿病功效评估

Assessment of anti-diabetic activity of the aqueous extract of leaves of Astilboides tabularis
2016-12-28 16:41发表评论
作者:Liu, Z., Zhai, J., Han, N., Yin, J.
机构: 沈阳药科大学中药学院
期刊: J Ethnopharmacol2016年12月24期194卷

Ethnopharmacological relevance Astilboides tabularis has a long history of usage as the functional food with the effect of adjunctive therapy of diabetic in northeast of China. The present study was undertaken to assess anti-diabetic activity of the aqueous extract of leaves of A. tabularis and provided experimental evidence for the clinical usage of A. tabularis in the treatment of diabetes mellitus. Materials and methods The aqueous extracts of leaves of A. tabularis (EAT) were orally administered at 300 and 600 mg/kg dose to epinephrine-induced and alloxan-induced diabetes mice. Hypoglycemic effects, change in body weight, water intake, food intake, lipid profile and lipid peroxidant were assessed. Furthermore, the main chemical components of EAT were isolated and high performance liquid chromatography (HPLC) analysis was employed to identify the phytochemical composition of the plant extract. The finally, total flavonoids content and total phenolic content were quantified by colorimetric assay. Results EAT showed a significant reduction in blood glucose level at both 300 and 600 mg/kg (ig). In addition, EAT also exhibited a profound antioxidant effect for increasing SOD and GSH-px activity and decreasing TBARS activity at both low and high dose. Furthermore, EAT also could significantly decrease the contents of TC and TG. The 8 main constituents of EAT are also isolated and characterized and the content of total flavonoid and total phenolic are 22% and 25% in EAT respectively. Conclusion The present investigation revealed that EAT possess potent anti-diabetic activity and polyphenol compounds may be the main active ingredients. © 2016 Elsevier Ireland Ltd

通讯机构:Department of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang, China
学科代码:内科学 补充和替代医学 药学   关键词:山荷叶叶片水溶液 治疗糖尿病 ,中国作者重要发表 爱思唯尔医学网, Elseviermed
来源: Scopus
Scopus介绍:Scopus 于2004年11月正式推出,是目前全球规模最大的文摘和引文数据库。Scopus涵盖了由5000多家出版商出版发行的科技、医学和社会科学方面的18,000多种期刊,其中同行评审期刊16,500多种。相对于其他单一的文摘索引数据库而言,Scopus的内容更加全面,学科更加广泛,特别是在获取欧洲及亚太地区的文献方面,用户可检索出更多的文献数量。通过Scopus,用户可以检索到1823年以来的近4000万条摘要和题录信息,以及1996年以来所引用的参考文献。数据每日更新。 马上访问Scopus网站http://www.scopus.com/
顶一下(0
您可能感兴趣的文章
发表评论网友评论(0)
发表评论
登录后方可发表评论,点击此处登录