何首乌原药及制品所致小鼠肝损伤中尿液代谢研究并结合模式识别及通路分析

Urine metabolomics study on the liver injury in rats induced by raw and processed Polygonum multiflorum integrated with pattern recognition and pathways analysis
2017-01-10 07:33发表评论
作者:Zhang, C.-E., Niu, M., Li, Q., Zhao, Y.-L., Ma, Z.-J., Xiong, Y., Dong, X.-P., Li, R.-Y., Feng, W.-W., Dong, Q., Ma, X., Zhu, Y., Zou, Z.-S., Cao, J.-L., Wang, J.-B., Xiao, X.-H.
机构: 军事医学科学院,解放军302医院
期刊: J Ethnopharmacol2016年12月12期194卷

Ethnopharmacological relevance Polygonum multiflorum L. is a famous traditional Chinese medicine that has always been perceived to be safe. Recently, the increasing case reports on hepatotoxicity induced by Raw P. multiflorum (RP) have attracted particular attention. However, the diagnosis and identification of RP-induced hepatotoxicity are still very difficult for its unknown mechanism and the lack of specific biomarkers. Aim of the study To further explore the toxicity and metabolic mechanisms involved in the hepatotoxicity induced by RP. Materials and methods The hepatotoxicity induced by RP and its processed products (PP) (dosed at 20 g/kg for 4 weeks) on rats were investigated using conventional approaches including the biochemical analysis and histopathological observations. Further, a urinary metabolomic approach was developed to study the metabolic disturbances caused by RP and PP, followed by the pattern recognition approach and pathways analysis. Results RP showed obvious hepatotoxity whereas PP did not. 16 potential biomarkers (pyridoxamine, 4-pyridoxic acid, citrate et al.) differentially expressed in RP group were identified compared with the control and PP-treated groups. The pathways analysis showed that vitamin B6 metabolism, tryptophan metabolism and citrate cycle might be the major enriched pathways involved in the hepatotoxicity of the herb. Conclusion 16 differentially expressed metabolites were identified to be involved in the RP-induced hepatotoxicity. Vitamin B6 metabolism might be mostly related to the hepatotoxicity induced by RP. This finding may provide a potential therapeutic target or option to treat hepatotoxicity induced by RP. © 2016 Elsevier Ireland Ltd

通讯机构:China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing, China
学科代码:内科学 补充和替代医学 药学   关键词:何首乌原药 小鼠肝损伤 尿液代谢 ,中国作者重要发表 爱思唯尔医学网, Elseviermed
来源: Scopus
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