早期食管鳞状上皮肿瘤内镜下多环粘膜切除的长期预后-一项回顾性单中心研究

Long-term outcomes of endoscopic multiband mucosectomy for early esophageal squamous cell neoplasia: a retrospective, single-center study
2017-01-12 16:14发表评论
作者:Wang, Z., Lu, H., Wu, L., Yuan, B., Liu, J., Shi, H., Wang, F.
机构: 江苏省南京金陵医院消化及肝病科
期刊: GASTROINTEST ENDOSC 2016年12月6期84卷

Background and Aims Endoscopic multiband mucosectomy (EMBM) has been used to treat early Barrett's esophagus and esophagogastric junction neoplasia, yet it is seldom reported for the treatment of early esophageal squamous cell neoplasia. Here we retrospectively evaluated the feasibility, safety, and efficacy of EMBM for early esophageal squamous cell neoplasia. Methods A total of 125 patients were included in the study. Lesions were delineated using electrocoagulation and resected using the EMBM technique. The primary outcomes were local recurrence and adverse events. Secondary outcomes were histology of the endoscopic resection specimens, specimen area, and speed of resection. All patients were followed up endoscopically. Results There were 135 esophageal lesions, of which 40 were pathologically diagnosed as low-grade intraepithelial neoplasia, 57 as high-grade intraepithelial neoplasia, 34 as early esophageal cancer, and 4 as squamous epithelium without neoplasia. No severe adverse events were observed, except for 1 perforation, which was treated by application of clips. The median follow-up was 27.75 months. Three patients had local recurrence and were endoscopically treated again. Local recurrence rate was 2.4% (3/125). No deaths occurred during the follow-up. All specimens were visible with a dividing rule, and the mean specimen area was 4.63 cm2. Mean operation time was 31.2 ± 17.4 minutes. Mean speed of resection was 6.74 min/cm2. Conclusions EMBM seems to be effective and safe for patients with early esophageal squamous cell neoplasia. The long-term recurrence rate is low. © 2016 American Society for Gastrointestinal Endoscopy

通讯机构:Department of Gastroenterology and Hepatology, Jinling Hospital, Nanjing, Jiangsu Province, China
学科代码:消化病学   关键词:早期食管鳞状上皮肿瘤 多环粘膜切除 ,中国作者重要发表 爱思唯尔医学网, Elseviermed
来源: Scopus
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