Epstein–Bar病毒编码EBNA2介导miR-21 和miR-146a分化调控

Differential regulation of miR-21 and miR-146a by Epstein–Barr virus-encoded EBNA2
作者:P Rosato
期刊: LEUKEMIA2012年11月11期26卷

Abstract

The discovery of microRNA (miR) represents a novel paradigm in RNA-based regulation of gene expression and their dysregulation has become a hallmark of many a tumor. In virally associated cancers, the host–pathogen interaction could involve alteration in miR expression. Epstein–Barr virus (EBV)-encoded EBNA2 is indispensable for the capacity of the virus to transform B cells in vitro. Here, we studied how it affects cellular miRs. Extensive miR profiling of the virus-infected and EBNA2-transfected B lymphoma cells revealed that oncomiR miR-21 is positively regulated by this viral protein. Conversely, Burkitt’s lymphoma (BL) cell lines infected with EBNA2 lacking P3HR1 strain did n


学科代码:血液病学   关键词:EBV EBNA2; DLBCL microRNA miR-21 miR-146a
来源: Leukemia
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