对特发性少精子症不育的血压正常男性采用小剂量赖诺普利治疗:一项为期5年的随机、对照、交叉的初步研究

Low-Dose Lisinopril in Normotensive Men With Idiopathic Oligospermia and Infertility: A 5-Year Randomized, Controlled, Crossover Pilot Study
作者:Mbah, A...U..., Ndukwu, G...O..., Ghasi, S...I... 【View at publisher】 【全球专家评论】
期刊: Clin Pharmacol Ther2012年10月期91卷 专家评级: 循证评级:A

he outcomes of drug treatment for male infertility remain conjectural, with controversial study results. Our pilot study employed a randomized, placebo-controlled, crossover methodology with intention-to-treat analysis. Thirty-three men with idiopathic oligospermia were randomized to start either daily oral lisinopril 2.5mg (n=17) or daily oral placebo (n=16). Lisinopril was found to cause a normalization of seminal parameters in 53.6% of the participants. Although the mean ejaculate volume was unchanged (P≥0.093), the total sperm cell count and the percentage of motile sperm cells increased (P≤0.03 and P<0.001, respectively), whereas the percentage of sperm cells with abnormal morphology decreased (P≤0.04). The pregnancy rate was 48.5%, and there was no serious adverse drug event. It is concluded, albeit cautiously, that prolonged treatment with 2.5mg/day of oral lisinopril may be well tolerated in normotensive men with idiopathic oligospermia, may improve sperm quantity and quality, and may enhance fertility in approximately half of those treated.

学科代码:泌尿外科学   关键词:小剂量赖诺普利治疗
来源: Eclips
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