肠道CD103−树突状细胞可在淋巴结和主要效应T细胞内迁移
Abstract
Intestinal dendritic cells (DCs) continuously migrate through lymphatics to mesenteric lymph nodes where they initiate immunity or tolerance. Recent research has focused on populations of intestinal DCs expressing CD103. Here we demonstrate, for the first time, the presence of two distinct CD103− DC subsets in intestinal lymph. Similar to CD103+ DCs, these intestine-derived CD103− DCs are responsive to Flt3 and they efficiently prime and confer a gut-homing phenotype to naive T cells. However, uniquely among intestinal DCs, CD103− CD11b+ CX3CR1int lymph DCs induce the differentiation of both interferon-γ and interleukin-17-producing effector T cells, even in the absence of overt sti
来源: Mucosal Immunology
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