肠道CD103−树突状细胞可在淋巴结和主要效应T细胞内迁移

Intestinal CD103? dendritic cells migrate in lymph and prime effector T cells
作者:V Cerovic
期刊: MUCOSAL IMMUNOL2013年1月1期6卷

Abstract

Intestinal dendritic cells (DCs) continuously migrate through lymphatics to mesenteric lymph nodes where they initiate immunity or tolerance. Recent research has focused on populations of intestinal DCs expressing CD103. Here we demonstrate, for the first time, the presence of two distinct CD103 DC subsets in intestinal lymph. Similar to CD103+ DCs, these intestine-derived CD103 DCs are responsive to Flt3 and they efficiently prime and confer a gut-homing phenotype to naive T cells. However, uniquely among intestinal DCs, CD103 CD11b+ CX3CR1int lymph DCs induce the differentiation of both interferon-γ and interleukin-17-producing effector T cells, even in the absence of overt sti


学科代码:变态反应、哮喘病与免疫学   关键词:none
来源: Mucosal Immunology
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