拉喹莫德可通过降低胶质细胞NF-κB活化预防 cuprizone致脱髓鞘
Reduced astrocytic NF-κB activation by laquinimod protects from cuprizone-induced demyelination
Abstract
Laquinimod (LAQ) is a new oral immunomodulatory compound that reduces relapse rate, brain atrophy and disability progression in multiple sclerosis (MS). LAQ has well-documented effects on inflammation in the periphery, but little is known about its direct activity within the central nervous system (CNS). To elucidate the impact of LAQ on CNS-intrinsic inflammation, we investigated the effects of LAQ on cuprizone-induced demyelination in mice in vivo and on primary CNS cells in vitro. Demyelination, inflammation, axonal damage and glial pathology were evaluated in LAQ-treated wild type and Rag-1-deficient mice after cuprizone challenge. Using primary cells we tested for effects of L
学科代码：神经病学 关键词：Demyelination Laquinimod Cuprizone Astrocytes NF-κB Multiple sclerosis
来源： Acta Neuropathologica
来源： Acta Neuropathologica
顶一下（0）
- 您可能感兴趣的文章
-
