TRPM7经血管紧张素ii调控可激发升主动脉平滑肌细胞表型转换

Rationale: Angiotensin II (Ang II) has pleiotropic effects on vascular smooth muscle cells (VSMCs). It has been demonstrated to promote the proliferative phenotype of VSMCs in mouse ascending aorta, but the underlying mechanisms remain incompletely understood.

Objective: The present study was designed to explore whether the Ca²⁺-permeable transient receptor potential melastatin 7 (TRPM7) channel is involved in Ang II–induced phenotype switching of ascending aortic VSMCs and to dissect the molecular mechanisms by which TRPM7 modulates VSMC phenotype.

Methods and Results: As revealed by current recording, Ang II infusion increased TRPM7 whole-cell currents in ascending aortic VSMCs. The