2型糖尿病遗传易感性与胰岛素分泌下降相关，但不会影响胰岛素抵抗或降低食物中饱和脂肪酸干预所致分泌
Genetic predisposition to type 2 diabetes is associated with impaired insulin secretion but does not modify insulin resistance or secretion in response to an intervention to lower dietary saturated fat
Abstract
Genome-wide association studies have identified SNPs reproducibly associated with type 2 diabetes (T2D). We examined the effect of genetic predisposition to T2D on insulin sensitivity and secretion using detailed phenotyping in overweight individuals with no diagnosis of T2D. Furthermore, we investigated whether this genetic predisposition modifies the responses in beta-cell function and insulin sensitivity to a 24-week dietary intervention. We genotyped 25 T2D-associated SNPs in 377 white participants from the RISCK study. Participants underwent an IVGTT prior to and following a dietary intervention that aimed to lower saturated fat intake by replacement with monounsaturated fat o
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学科代码：其他 关键词：Dietary intervention SNP Insulin resistance Insulin secretion Saturated fat IVGTT
来源： Genes and Nutrition
来源： Genes and Nutrition
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