By Marschall S. Runge, MD, PhD, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA; Cam Patterson, MD, Chief, Division of Cardiology, Ernest and Hazel Craige Distinguished Professor of Cardiovascular Medicine; Director of the Carolina Cardiovascular Biology Center, Department of Medicine, Faculty in Pharmacology as well as Cell and Developmental Biology and George Stouffer, MD, Professor of Medicine Director, C.V. Richardson Cardiac Catheterization Laboratory Director, Interventional Cardiology