结直肠癌爱思唯尔期刊精选全文订阅_爱唯医学网 http://www.elseviermed.cn/drc/fulltext/colorectal_cancer 爱唯医学网结直肠癌资源中心是结直肠癌相关资讯的综合平台,致力于为广大医生和科研工作者提供最专业、最有价值的结直肠癌相关信息,内容覆盖结直肠癌领域的国外最新进展、期刊发表、临床指南、原版图书介绍、病例讨论、会议报道、国内外医学专家学术成果等,以及常用药物、会议预告等实用信息查询。 感染是全球问题:感染解决全球问题 http://www.elseviermed.cn/article/detail/Infection_is_a_global_problem_infection_to_solve_global_problems AbstractInfections are of unifying global concern, despite regional differences in disease epidemiology, clinical appearance and the instruments to tackle them. The primary aim of Infection is “to be a forum for the presentation and discussion of clinically relevant information on infectious diseases… from all over the world”. To that end, and as a reflection of the global burd... 2013/4/18 9:48:28 M. P. Grobusch 奥沙利铂相关毒性处理的概述及临床观点 http://www.elseviermed.cn/article/detail/Capecitabine_platinum_related_toxic_processing_overview 摘 要结直肠癌是目前公共卫生的一项重要事项。在西方国家,结直肠癌是癌症死亡的第二大原因。在结直肠癌的姑息治疗和辅助治疗中,奥沙利铂联合输注氟尿嘧啶/甲酰四氢叶酸或口服卡培他滨已经成为结直肠癌姑息治疗和辅助治疗的重要选择。奥沙利铂的耐受性尽管较顺铂好,但也有其特殊的不良反应。治疗结直肠癌或其他癌症的临床医师识别和处理这些不良事件至关重要。周围神经病变很可能是与奥沙利铂相关的临床最常见的不良事件,已有若干措施被提出用以减轻这种毒性。在神经毒性进一步加重前暂时停用奥沙利铂,可能是转移性结直肠癌患者避免奥沙利铂相关神经毒性的一种有效方法。钙镁输注不影响化疗疗效,在临床上也是一种有效的措施。另外,神经保护剂如文拉法辛可能可以降低奥沙利铂相关的慢性周围神经病变的发生率和严重程度。本文还将阐述其他不良事件,如胃肠道和肝脏毒性、血小板减少症和过敏反应,并对其管理给出建议。前言世界范围内,结直肠癌是男、女... 2013/2/5 18:15:42 Paulo M. Hoff, Everardo D. Saad, Frederico Costa, 新生儿生产捐献者基金:2002-2010捐献者报告数据分析 http://www.elseviermed.cn/article/detail/Neonatal_production_donor_fund_20022010_donors_report_data_analysis Abstract TopBackgroundNeonatal mortality accounts for 43% of global under-five deaths and is decreasing more slowly than maternal or child mortality. Donor funding has increased for maternal, newborn, and child health (MNCH), but no analysis to date has disaggregated aid for newborns. We evaluated if and how aid flows for newborn care can be tracked, examined changes in the last decade, and consid... 2012/12/5 20:41:50 Catherine Pitt 早发性家族性结直肠癌中的肿瘤抑制基因PTPRJ的生殖细胞系表观遗传沉默 http://www.elseviermed.cn/article/detail/Praecox_familial_in_colorectal_cancer_tumor_suppressor_genes_PTPRJ_reproductive_cell_lines_epigenetic_silence Recently, we showed that 3′ deletion of the EPCAMgene leads to allele-specific epigeneticsilencing of the neighboring MSH2gene in Lynch syndrome patients.1 The underlying mechanism was found to constitute MSH2 promoter hypermethylation mediated by transcriptional read-through, thus providing an explanation of how colorectalcancer (CRC) susceptibility in these families could be inherited. Based on ... 2012/2/21 15:20:00 Ramprasath Venkatachalam, Marjolijn J.L. Ligtenber 结直肠癌普查时代结肠镜检查前的肠道准备:一种实用的方法 http://www.elseviermed.cn/article/detail/Colorectal_cancer_before_age_colonoscopy_census_of_the_bowel_preparation_a_practical_method Colonoscopy constitutes the principal investigation for colo-rectal neoplasms due to its ability to detect and remove most of precancerous lesions; due to the ongoing or planned colon cancer screening programs in many European countries we should expect an enormous increase in colonoscopic demand over the next few years. Diagnostic accuracy and therapeutic safety of colonoscopy strictly depends up... 2011/2/24 13:45:00 F. Parente, B. Marino, C. Crosta 急需同等资金来支持评估循证和指南推荐结直肠癌筛查试验的研究 http://www.elseviermed.cn/article/detail/Need_money_to_support_the_same_assessment_evidencebased_guidelines_recommend_and_colorectal_cancer_screening_trial_research In colorectal (CRC) screening guidelines published before 2008, flexible sigmoidoscopy (FS) plus fecal occult blood test (FOBT) was a recommended option. In 2008 the American Cancer Society/US Multisociety Taskforce and American College of Radiology guidelines5 dropped this recommendation and the US Preventive Services guidelines (USPSTF)6 changed its recommendation to FS and high-sensitivity FOBT... 2011/2/23 14:43:00 James E. Allison 结直肠癌发病机制中基因组和表观遗传的不稳定性 http://www.elseviermed.cn/article/detail/Colorectal_cancer_pathogenesis_of_genome_and_epigenetic_instability Colorectal cancer arises as a consequence of the accumulation of genetic alterations (gene mutations, gene amplification, and so on) and epigenetic alterations (aberrant DNA methylation, chromatin modifications, and so on) that transform colonic epithelial cells into colon adenocarcinoma cells. The loss of genomic stability and resulting gene alterations are key molecular pathogenic steps that occ... 2009/3/18 9:25:00 William M. Grady, John M. Carethers 针对结直肠癌和腺瘤性息肉早期诊断的筛查和监测,2008:来自美国癌症学会、美国结直肠癌协作组以及美国放射学会的联合指南 http://www.elseviermed.cn/article/detail/For_colorectal_cancer_and_adenomatous_polyps_early_diagnosis_of_screening_and_monitoring_2008_from_the_American_cancer_society_the_United_States_colorectal_cancer_and_the_United_States_to_continue_the In the United States, colorectal cancer (CRC) is the third most common cancer diagnosed among men and women and the second leading cause of death from cancer. CRC largely can be prevented by the detection and removal of adenomatous polyps, and survival is significantly better when CRC is diagnosed while still localized. In 2006 to 2007, the American Cancer Society, the US Multi-Society Task Force ... 2009/3/18 9:25:00 Bernard Levin, David A. Lieberman, Beth McFarland,