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Published 2012年9月,Volume 118,Issue 17

最新一期

  1. CancerScope

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      US representatives honored for their support of cancer research : The lawmakers have advocated for NIH funding, breakthrough therapies, and drug shortage solutions (pages 4095–4096)

      Carrie Printz

      Article first published online: 20 AUG 2012 | DOI: 10.1002/cncr.27777

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      Genetic test predicts whether eye cancer will spread (page 4096)

      Carrie Printz

      Article first published online: 20 AUG 2012 | DOI: 10.1002/cncr.27778

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      Studies for colorectal cancer screening not properly designed (page 4097)

      Carrie Printz

      Article first published online: 20 AUG 2012 | DOI: 10.1002/cncr.27779

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      High-throughput sequencing detects signs of cancer recurrence (page 4097)

      Carrie Printz

      Article first published online: 20 AUG 2012 | DOI: 10.1002/cncr.27780

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  2. Original Articles

    1. Disease Site

      Breast Disease
      An open-label, phase 2 trial of RPI.4610 (angiozyme) in the treatment of metastatic breast cancer (pages 4098–4104)

      Phuong Khanh Morrow, Rashmi K. Murthy, Joe D. Ensor, Gilad S. Gordon, Kim A. Margolin, Anthony D. Elias, Walter J. Urba, David E. Weng, Hope S. Rugo and Gabriel N. Hortobagyi

      Article first published online: 26 JAN 2012 | DOI: 10.1002/cncr.26730

      This phase 2 study evaluates the objective response rate of RPI.4610 (Angiozyme), an antiangiogenic ribozyme that targets vascular endothelial growth factor receptor 1 mRNA. Although RPI.4610 demonstrates a well-tolerated safety profile, its lack of clinical efficacy precludes this drug from further development.

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    2. Ras homolog gene family, member A promotes p53 degradation and vascular endothelial growth factor-dependent angiogenesis through an interaction with murine double minute 2 under hypoxic conditions (pages 4105–4116)

      Ji Ma, Yan Xue, Wei Cui, Yan Li, Qingli Zhao, Wenmin Ye, Jin Zheng, Yuanxiong Cheng, Yuguang Ma, Sen Li, Tenglong Han, Lu Miao, Libo Yao, Jian Zhang and Wenchao Liu

      Article first published online: 3 JAN 2012 | DOI: 10.1002/cncr.27393

      The current data suggest that activated ras homolog gene family, member A (RhoA) promotes vascular endothelial growth factor (VEGF) expression and hypoxia-induced angiogenesis through the up-regulation of the p53 binding protein homolog murine double minute 2 (MDM2) to decrease p53 stability. Data from 129 breast cancer clinical specimens with wild-type p53 reveal that high RhoA expression is correlated with high MDM2 expression, low wild-type p53 expression, and high VEGF expression.

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    3. Comparative analysis of clinicopathologic features, treatment, and survival of Asian women with a breast cancer diagnosis residing in the United States (pages 4117–4125)

      Min Yi, Peijun Liu, Xu Li, Elizabeth A. Mittendorf, Jianjun He, Yu Ren, Khazi Nayeemuddin and Kelly K. Hunt

      Article first published online: 3 JAN 2012 | DOI: 10.1002/cncr.27399

      Population-based data demonstrate breast cancer disparities in Asian patients residing in the United States as evidenced by heterogeneity in tumor characteristics and outcomes.

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    4. Outcome after ipsilateral breast tumor recurrence in patients who receive accelerated partial breast irradiation (pages 4126–4131)

      Chirag Shah, Frank Vicini, Martin Keisch, Henry Kuerer, Peter Beitsch, Bruce Haffty and Maureen Lyden

      Article first published online: 17 JAN 2012 | DOI: 10.1002/cncr.27400

      In the largest review of outcomes after ipsilateral breast tumor recurrence in patients who receive accelerated partial breast irradiation, excellent outcomes are noted with short-term follow-up. In the limited number of patients who underwent repeat breast conservation after developing a recurrence, outcomes comparable to those after traditional salvage procedures are noted.

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    5. Discipline

      Gastrointestinal Disease
      A double-blind, randomized, placebo-controlled, phase 2 study of maintenance enzastaurin with 5-fluorouracil/leucovorin plus bevacizumab after first-line therapy for metastatic colorectal cancer (pages 4132–4138)

      Robert A. Wolff, Martin Fuchs, Maria Di Bartolomeo, Anwar M. Hossain, Clemens Stoffregen, Steven Nicol and Volker Heinemann

      Article first published online: 27 DEC 2011 | DOI: 10.1002/cncr.26692

      Enzastaurin combined with bevacizumab-based therapy is tolerable, but does not improve progression-free survival over bevacizumab-based therapy alone.

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    6. Disease Site

      Genitourinary Disease
      Efficacy of peripheral androgen blockade in prostate cancer patients with biochemical failure after definitive local therapy : Results of Cancer and Leukemia Group B (CALGB) 9782 (pages 4139–4147)

      J. Paul Monk, Susan Halabi, Joel Picus, Arif Hussain, George Philips, Ellen Kaplan, Tim Ahles, Lin Gu, Nicholas Vogelzang, William K. Kelly and Eric J. Small, for the Cancer and Leukemia Group B

      Article first published online: 16 DEC 2011 | DOI: 10.1002/cncr.26732

      Prostate-specific antigen failure after curative intent treatment of prostate cancer is a common scenario, and the optimal management for this disease state is unknown. The combination of finasteride and flutamide is associated with durable disease control and may prove to be an option for these men.

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    7. Focal salvage therapy for localized prostate cancer recurrence after external beam radiotherapy : A pilot study (pages 4148–4155)

      Hashim Uddin Ahmed, Paul Cathcart, Neil McCartan, Alex Kirkham, Clare Allen, Alex Freeman and Mark Emberton

      Article first published online: 3 JAN 2012 | DOI: 10.1002/cncr.27394

      Focal salvage therapy has been proposed as an alternative that may provide treatment for localized radiorecurrent disease while reducing the impact on functional status. This study demonstrates that focal salvage therapy using high-intensity focused ultrasound for radiorecurrent prostate cancer is feasible and appears to exhibit a favorable balance of harms and benefits.

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    8. Hematologic Malignancies
      Limited-stage diffuse large B-cell lymphoma treated with abbreviated systemic therapy and consolidation radiotherapy : Involved-field versus involved-node radiotherapy (pages 4156–4165)

      Belinda A. Campbell, Joseph M. Connors, Randy D. Gascoyne, W. James Morris, Tom Pickles and Laurie H. Sehn

      Article first published online: 17 JAN 2012 | DOI: 10.1002/cncr.26687

      This is the first known body of work to apply the concept of involved-node radiotherapy to limited-stage diffuse large B-cell lymphoma treated with abbreviated systemic therapy and consolidation radiotherapy. Reducing the field size beyond the conventional involved-field radiotherapy field appears to be safe, with a very low risk of marginal recurrence and no impact on progression-free or overall survival rates.

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    9. Discipline

      Hematologic Malignancies
      Prognostic impact of extranodal involvement in diffuse large B-cell lymphoma in the rituximab era (pages 4166–4172)

      Hiroyuki Takahashi, Naoto Tomita, Masahiro Yokoyama, Saburo Tsunoda, Takahiro Yano, Kayoko Murayama, Chizuko Hashimoto, Kazuo Tamura, Kazuya Sato and Yoshiaki Ishigatsubo

      Article first published online: 27 DEC 2011 | DOI: 10.1002/cncr.27381

      Retrospective analysis of 1221 diffuse large B-cell lymphoma patients who have been uniformly treated with R-CHOP therapy detects prognostic impact for 8 extranodal sites. Waldeyer ring involvement has significantly better prognosis and should be treated as an extranodal lesion.

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    10. Prognostic significance of MYCBCL2, and BCL6 rearrangements in patients with diffuse large B-cell lymphoma treated with cyclophosphamide, doxorubicin, vincristine, and prednisone plus rituximab (pages 4173–4183)

      Nalan Akyurek, Aysegul Uner, Mustafa Benekli and Ibrahim Barista

      Article first published online: 27 DEC 2011 | DOI: 10.1002/cncr.27396

      Diffuse large B-cell lymphomas with rearrangements of MYC or BCL6 are significantly associated with worse overall survival in patients treated with cyclophosphamide, doxorubicin, vincristine, and prednisone plus rituximab. Patients with concurrent rearrangements of MYC and BCL2 and/or BCL6 have extremely poor prognosis. The results suggest that analysis of MYC gene rearrangement along with BCL2 and BCL6is critical in identification of high-risk patients with poor prognosis.

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    11. Disease Site

      Melanoma
      Single versus multiple primary melanomas : Old questions and new answers(pages 4184–4192)

      Charlotte Hwa, Leah S. Price, Ilana Belitskaya-Levy, Michelle W. Ma, Richard L. Shapiro, Russell S. Berman, Hideko Kamino, Farbod Darvishian, Iman Osman and Jennifer A. Stein

      Article first published online: 13 JAN 2012 | DOI: 10.1002/cncr.27407

      There is no difference in the presence or absence of mitosis, a marker of tumor proliferation, in tumors from patients with single and multiple primary melanomas. Because it has been demonstrated that the presence of mitosis is a powerful prognostic marker in patients with melanoma, the current findings suggest that the tumors behave similarly in patients with single and multiple primary melanomas.

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    12. Neuro-Oncology
      Extended field stereotactic radiosurgery for recurrent glioblastoma (pages 4193–4200)

      Tomoyuki Koga, Keisuke Maruyama, Minoru Tanaka, Yasushi Ino, Nobuhito Saito, Keiichi Nakagawa, Junji Shibahara and Tomoki Todo

      Article first published online: 16 DEC 2011 | DOI: 10.1002/cncr.27372

      To exploit the usefulness of stereotactic radiosurgery (SRS) for small recurrent lesions of glioblastoma, the modified clinical target volume is defined by adding a 0.5- to 1-cm margin to the gadolinium-enhanced area (extended field SRS), in contrast to conventional SRS using no margin to set the clinical target volume. Extended field SRS is superior to conventional SRS in the local control of small recurrent lesions of glioblastoma, although a further device to suppress remote dissemination may be necessary to increase survival.

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    13. Comparative assessment of 5 methods (methylation-specific polymerase chain reaction, methylight, pyrosequencing, methylation-sensitive high-resolution melting, and immunohistochemistry) to analyze O6-methylguanine-DNA-methyltranferase in a series of 100 glioblastoma patients (pages 4201–4211)

      Véronique Quillien, Audrey Lavenu, Lucie Karayan-Tapon, Catherine Carpentier, Marianne Labussière, Thierry Lesimple, Olivier Chinot, Michel Wager, Jérome Honnorat, Stephan Saikali, Frédéric Fina, Marc Sanson and Dominique Figarella-Branger

      Article first published online: 31 JAN 2012 | DOI: 10.1002/cncr.27392

      In this study, O6-methylguanine-DNA-methyltranferase status analyzed by either methylation-specific polymerase chain reaction, methylation-sensitive high-resolution melting, pyrosequencing, MethyLight, or immunohistochemistry is associated with overall survival and progression-free survival, but depending on the method, the percentage of patients classified as potential responders to alkylating agents varies from 33% to 60%. Among the tested techniques, we can recommend pyrosequencing because of its clinical performance and its good reproducibility and sensitivity.

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    14. Survival outcomes in atypical teratoid rhabdoid tumor for patients undergoing radiotherapy in a Surveillance, Epidemiology, and End Results analysis (pages 4212–4219)

      Daniela L. Buscariollo, Henry S. Park, Kenneth B. Roberts and James B. Yu

      Article first published online: 27 DEC 2011 | DOI: 10.1002/cncr.27373

      There is a robust association between primary or adjuvant radiotherapy (RT) and improved median overall survival in patients with atypical teratoid rhabdoid tumor (ATRT), and that association is stronger for patients aged ≤3 years. The inclusion of initial RT for patients aged ≤3 years in future prospective studies is needed to delineate the role of RT in the treatment of ATRT.

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    15. Descriptive epidemiology of malignant and nonmalignant primary spinal cord, spinal meninges, and cauda equina tumors, United States, 2004-2007 (pages 4220–4227)

      Linh M. Duong, Bridget J. McCarthy, Roger E. McLendon, Therese A. Dolecek, Carol Kruchko, Lynda L. Douglas and Umed A. Ajani

      Article first published online: 3 JAN 2012 | DOI: 10.1002/cncr.27390

      This large population-based study adds new insights into the descriptive epidemiology of primary spinal cord, spinal meninges, and cauda equina tumors. It provides in-depth analyses of the incidence of these tumors on a national level.

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    16. Improving prognosis of glioblastoma in the 21st century: Who has benefited most?(pages 4228–4234)

      Yaacov Richard Lawrence, Mark V. Mishra, Maria Werner-Wasik, David W. Andrews, Timothy N. Showalter, Jon Glass, Xinglei Shen, Zvi Symon and Adam P. Dicker

      Article first published online: 16 DEC 2011 | DOI: 10.1002/cncr.26685

      Overall survival in glioblastoma improved incrementally from 2001 to 2007. However, this improvement has been confined to patients less than 70 years of age and has been most prominent among patients living in high-income districts.

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    17. Soft Tissue and Bone Sarcoma
      Gene expression identifies heterogeneity of metastatic propensity in high-grade soft tissue sarcomas (pages 4235–4243)

      Keith M. Skubitz, Princy Francis, Amy P. N. Skubitz, Xianghua Luo and Mef Nilbert

      Article first published online: 17 JAN 2012 | DOI: 10.1002/cncr.26733

      Hierarchical clustering using a composite gene set derived from studies of renal carcinoma, ovarian carcinoma, and aggressive fibromatosis suggest the existence of subsets of 73 samples of high-grade soft tissue sarcoma (STS). Analysis reveals differences in the time to development of metastatic disease between the clusters defined by the first branch point of the clustering dendrogram, and also among the 4 different clusters defined by the second branch points, suggesting that such an approach may be useful in the management of STS.

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    18. Discipline

      Clinical Trials
      Phase 2 results from Radiation Therapy Oncology Group Study 0537 : A phase 2/3 study comparing acupuncture-like transcutaneous electrical nerve stimulation versus pilocarpine in treating early radiation-induced xerostomia (pages 4244–4252)

      Raimond K. W. Wong, Jennifer L. James, Stephen Sagar, Gwen Wyatt, Phuc Felix Nguyen-Tân, Anurag K. Singh, Barbara Lukaszczyk, Francis Cardinale, Alexander M. Yeh and Lawrence Berk

      Article first published online: 17 JAN 2012 | DOI: 10.1002/cncr.27382

      Acupuncture-like transcutaneous nerve stimulation (ALTENS) treatment for radiation-induced xerostomia can be delivered uniformly in a cooperative, multicenter setting and has possible beneficial treatment response. Given these positive results, the phase 3 component of this study comparing ALTENS with pilocarpine was initiated.

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    19. A method for analyzing the business case for provider participation in the National Cancer Institute's Community Clinical Oncology Program and similar federally funded, provider-based research networks (pages 4253–4261)

      Kristin L. Reiter, Paula H. Song, Lori Minasian, Marjorie Good, Bryan J. Weiner and Ann Scheck McAlearney

      Article first published online: 27 DEC 2011 | DOI: 10.1002/cncr.27375

      The literature currently provides little practical guidance to assist provider organizations in analyzing the return on investment, or business case, for establishing and operating provider-based research networks, such as the National Cancer Institute's Community Clinical Oncology Program (CCOP). In this report, the authors present a conceptual model of the business case, a spreadsheet-based tool and advice to help evaluate the business case for provider participation in a CCOP organization.

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    20. A phase 1 trial of E7974 administered on day 1 of a 21-day cycle in patients with advanced solid tumors (pages 4262–4270)

      Caio M. Rocha-Lima, Soley Bayraktar, Jessica MacIntyre, Luis Raez, Aurea M. Flores, Annapoorna Ferrell, Eric H. Rubin, Elizabeth A. Poplin, Antoinette R. Tan, Antonio Lucarelli and Naseem Zojwalla

      Article first published online: 31 JAN 2012 | DOI: 10.1002/cncr.27428

      This study shows that E7974 once every 21-day cycle shows antitumor activity in patients with refractory solid tumors. The recommended phase 2 dose is 0.45 mg/m2.

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    21. Disparities Research
      Survival disparities by Medicaid status : An analysis of 8 cancers (pages 4271–4279)

      Siran M. Koroukian, Paul M. Bakaki and Derek Raghavan

      Article first published online: 27 DEC 2011 | DOI: 10.1002/cncr.27380

      This study documents important disparities in survival outcomes for 8 cancers by Medicaid status. These disparities persist after adjusting for patient demographics, marital status, and county of residence.

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    22. Explaining racial differences in prostate cancer mortality (pages 4280–4289)

      Glen B. Taksler, Nancy L. Keating and David M. Cutler

      Article first published online: 13 JAN 2012 | DOI: 10.1002/cncr.27379

      Higher incidence of prostate cancer accounted for 76% of racial differences in prostate cancer mortality between blacks and whites, with the remainder due to higher stage-specific mortality after diagnosis. More frequent prostate-specific antigen testing for black and low-income males could potentially reduce the prostate cancer mortality gap through earlier diagnosis of tumors that otherwise may become metastatic.

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    23. Epidemiology
      Comparative incidence patterns and trends of gonadal and extragonadal germ cell tumors in England, 1979 to 2003 (pages 4290–4297)

      Ramandeep S. Arora, Robert D. Alston, Tim O. B. Eden, Marco Geraci and Jillian M Birch

      Article first published online: 17 JAN 2012 | DOI: 10.1002/cncr.27403

      Malignant germ cell tumors, which display heterogeneity by histology and site, occur at all ages with incidence peaks in infancy and young adulthood. Regardless of site, the similarity in shapes of the age-incidence curves of patients with germ cell tumors suggests a common initiation of these tumors in embryonic/fetal life with variable rates of tumor progression as a result of local factors or events during the postnatal and pubertal periods.

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    24. Medical Oncology
      Aberrant DNA methylation of tumor-related genes in oral rinse : A noninvasive method for detection of oral squamous cell carcinoma (pages 4298–4308)

      Satoshi Nagata, Tomofumi Hamada, Norishige Yamada, Seiya Yokoyama, Sho Kitamoto, Yuji Kanmura, Masahiro Nomura, Yoshiaki Kamikawa, Suguru Yonezawa and Kazumasa Sugihara

      Article first published online: 17 JAN 2012 | DOI: 10.1002/cncr.27417

      Aberrant methylation of a combination of marker genes present in oral rinse samples can be used to detect oral squamous cell carcinoma (OSCC) with over 90% sensitivity and specificity. Analysis of the methylation status of marker genes from oral rinse samples reveals great potential for the noninvasive detection of OSCC.

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    25. Comparison of adverse events during 5-fluorouracil versus 5-fluorouracil/oxaliplatin adjuvant chemotherapy for stage III colon cancer : A population-based analysis (pages 4309–4320)

      Hanna K. Sanoff, William R. Carpenter, Janet Freburger, Ling Li, Kun Chen, Leah L. Zullig, Richard M. Goldberg, Maria J. Schymura and Deborah Schrag

      Article first published online: 31 JAN 2012 | DOI: 10.1002/cncr.27422

      The addition of oxaliplatin to 5-fluorouracil-containing adjuvant therapy for stage III colon cancer increases the rate of outpatient adverse events reported in Medicare/Medicaid billing claims. Oxaliplatin does not increase emergency room use, hospitalization, or early mortality.

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    26. Pediatric Oncology
      Resumption of high-dose methotrexate after acute kidney injury and glucarpidase use in pediatric oncology patients (pages 4321–4330)

      Anthony M. Christensen, Jennifer L. Pauley, Alejandro R. Molinelli, John C. Panetta, Deborah A. Ward, Clinton F. Stewart, James M. Hoffman, Scott C. Howard, Ching-Hon Pui, Alberto S. Pappo, Mary V. Relling and Kristine R. Crews

      Article first published online: 17 JAN 2012 | DOI: 10.1002/cncr.27378

      Glucarpidase is an infrequently used but effective intervention for high-dose methotrexate-induced acute kidney injury. Resumption of high-dose methotrexate after glucarpidase administration is feasible.

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    27. Symptom Control and Palliative Care
      Augmenting advance care planning in poor prognosis cancer with a video decision aid : A preintervention-postintervention study (pages 4331–4338)

      Angelo E. Volandes, Tomer T. Levin, Susan Slovin, Richard D. Carvajal, Eileen M. O'Reilly, Mary Louise Keohan, Maria Theodoulou, Maura Dickler, John F. Gerecitano, Michael Morris, Andrew S. Epstein, Anastazia Naka-Blackstone, Elizabeth S. Walker-Corkery, Yuchiao Chang and Ariela Noy

      Article first published online: 17 JAN 2012 | DOI: 10.1002/cncr.27423

      Patients with advanced cancer who use a video decision aid are more knowledgeable about their end-of-life decisions and often prefer not to have cardiopulmonary resuscitation (CPR) or ventilation attempted. Despite having preferences against the use of CPR and ventilation, patients are unlikely to have a code status consistent with their preferences.

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    28. Radiation therapy at the end of life in patients with incurable nonsmall cell lung cancer (pages 4339–4345)

      Nirav S. Kapadia, Rizvan Mamet, Carrie Zornosa, Joyce C. Niland, Thomas A. D'Amico and James A. Hayman

      Article first published online: 17 JAN 2012 | DOI: 10.1002/cncr.27401

      The authors characterize the use of radiotherapy in patients with incurable nonsmall cell lung cancer during their last 14 days of life and observe that its use is infrequent, it is delivered more commonly to younger patients with more advanced disease, and it is completed as planned only approximately half of the time. There is also significant institutional variation in its use; thus, future investigations should aim to expand this research to other cancers and settings and to investigate the clinical benefit of such treatment.

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    29. Translational Research
      Association of Aurora-A (STK15) kinase polymorphisms with clinical outcome of esophageal cancer treated with preoperative chemoradiation (pages 4346–4353)

      Jennifer Y. Pan, Jaffer A. Ajani, Jian Gu, Yubo Gong, Angel Quin, Maosheng Hung, Xifeng Wu and Julie G. Izzo

      Article first published online: 27 DEC 2011 | DOI: 10.1002/cncr.26581

      Aurora kinase functional polymorphisms impacts clinical outcome of esophageal cancer treated with preoperative chemoradiation.

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    30. HER-2 pulsed dendritic cell vaccine can eliminate HER-2 expression and impact ductal carcinoma in situ (pages 4354–4362)

      Anupama Sharma, Ursula Koldovsky, Shuwen Xu, Rosemarie Mick, Robert Roses, Elizabeth Fitzpatrick, Susan Weinstein, Harvey Nisenbaum, Bruce L. Levine, Kevin Fox, Paul Zhang, Gary Koski and Brian J. Czerniecki

      Article first published online: 17 JAN 2012 | DOI: 10.1002/cncr.26734

      Vaccination against HER-2/neu induces decline and/or eradication of HER-2/neuexpression. These findings warrant further exploration of HER-2/neu vaccination in estrogen-independent breast cancer but highlight the need to target additional tumor-associated antigens and pathways.

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  3. Correspondence

    1. Differences in vitamin D status likely explain racial disparities in breast cancer mortality rates in the southeast (page 4363)

      William B. Grant, Luca Mascitelli and Mark R. Goldstein

      Article first published online: 27 DEC 2011 | DOI: 10.1002/cncr.27374

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    2. Reply to differences in vitamin D status likely explain racial disparities in breast cancer mortality rates in the southeast (page 4364)

      Swann Arp Adams, Susan E. Steck and James R. Hébert

      Article first published online: 27 DEC 2011 | DOI: 10.1002/cncr.27383

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  4. Erratum

    1. You have free access to this content
      Erratum (page 4365)

      Article first published online: 16 DEC 2011 | DOI: 10.1002/cncr.27384

      This article corrects:

      A phase II study of the survivin suppressant YM155 in patients with refractory diffuse large B-cell lymphoma

      Vol. 118Issue 123128–3134Article first published online: 17 OCT 2011

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