Cancer Research
(CANCER RES) 《癌症研究》
2013年影响因子
9.284
- 2014-08-11•近期使用口服避孕药与乳腺癌有关
- 2013-08-19•近20年前列腺癌分期比Gleason评分下降更多
- 2013-03-28•Ganetespib对ALK驱动型NSCLC有效
- 2013-03-07•结直肠癌某亚型与肥胖和活动不足相关
- 2012-11-27•食管、胃和结肠中的胃肠腺癌表现出明显不同的基因组不稳定性和瘤形成模式
- 2012-12-27•影响肿瘤和系统代谢的肥胖和进食过多可活化黄体酮受体使其同绝经后乳腺癌相关
- 2012-12-27•通过人结肠腺癌外显子测序发现的单核苷酸替换突变表型
- 2012-10-10•利用动态对比增强MRI揭示肿瘤中间质液压力和相关淋巴结转移
- 2012-10-10•以肿瘤中EphB4受体为靶点的载阿霉素金纳米球的光热化疗
- 2012-10-10•癌细胞中肿瘤抑制因子DLC1 和 Caveolin-1功能相互作用
- 2012-08-19•慢性自噬是一种对肿瘤酸性微环境的细胞适应性
- 2014-10-22•SIX1通过协同TGFβ信号通路增加VEGF-C的表达而促进肿瘤淋巴管生成
- 2014-10-22•AEG-1诱发的不可控炎症引起胃癌进展和预后不良
- 2014-10-21•PRMT7诱导上皮细胞间质转型并促进乳腺癌转移
- 2014-06-18•γδ T细胞生成的IL-17A可促进肝细胞癌生长
- 2014-06-17•对FHIT肿瘤抑制基因中的一种肿瘤抑制性人特异性MicroRNA的识别
- 2014-06-16•一种识别口腔鳞状细胞癌的有效肿瘤-基质常见靶点的系统生物学方法
最新一期
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Reviews
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Priority Report
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Precis:This study reinforces emerging concerns that the administration of mTOR inhibitors in cancer patients may actually confer higher risk of progression in some settings, possibly because of mTOR inhibition in the immune microenvironment, as opposed to tumor cells that may not be therapeutically desirable.
Clinical Studies
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Precis:This clinical study shows that to be effective, a cancer immunotherapy must coactivate CD4+ T cells, suggesting that future immunotherapy trials should aim at activating CD4+ T helper cells in an antigen-specific manner.
Integrated Systems and Technologies
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Precis:Findings describe a sound method to explore genomic events in cancer progression as well as monitor the efficacy of targeted therapies in clinical trials in a relatively noninvasive and low-cost manner.
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Precis:A novel quantitative approach that enables the measurement of patient-specific tumor characteristics extends insights into the great cellular complexity in cancer and offers a paradigm shift in molecular profiling, with implications for personalized treatment.
Microenvironment and Immunology
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Precis:RhoB is generally considered a cancer suppressor gene, but in vivostudies reveal that it exerts positive effects on angiogenesis that supercede its negative impact on cancer cells themselves, thereby illustrating how differential functions of a signaling protein in stromal cells can complicate the challenge of developing therapeutics that can effectively target cancer pathophysiology rather than cancer cells in isolation.
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Precis:Preclinical proof-of-principle studies establish a new cell-based therapy to coordinate the activation of innate and adaptive immunity against tumors as an effective strategy for cancer immunotherapy.
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Precis:Results show that the antitumor response to peptide-variant vaccines are markedly enhanced by subsequent immunization with the native antigen.
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Precis:The dynamically regulated expression signature for an important class of cell surface glycan-binding molecules in prostate cancer suggest a tractable target for antiangiogenic therapy in advanced disease.
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Precis:Despite recent encouraging results, oncolytic viruses have yet to find their niche in current cancer treatment, but they might be applied as neoadjuvant therapies to inhibit metastasis after surgical resection of tumors, by boosting the innate immune system that is suppressed post-operatively.
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Precis:This study challenges prevailing views in revealing that Angiopoietin-2 functions as a Tie2 activator in tumors, playing a protective rather than a destabilizing role in tumor endothelial cells.
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Precis:Dose-dense chemotherapy appears to improve the prognosis of patients with drug-resistant disease, however, the mechanistic basis for this effect has been undefined.
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Precis:Findings prompt a need to revisit the significance of PD-1-positive T cells that infiltrate tumors, where PD-1 detection may reflect a previous immune response against tumors that may be reactivated by PD-1/PD-L1 blockade.
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Precis:A strategy of IL-15 conjugation to a cholesterol-carrying lipoprotein can eradicate aggressive metastatic cancer in mice due to enhanced NK activity and CTL memory.
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Precis:Spatial and temporal analysis of focal areas of inflammatory hyperemia can predict not only whether tumors will form, but also where they will form during experimental skin carcinogenesis.
Molecular and Cellular Pathobiology
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Precis:Findings suggest that the effects of an angiogenic pathway on autophagy may mediate tumor cell survival in the face of chemotherapy, contributing to drug resistance.
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Precis:Findings establish the role of a receptor for a tissue damage-associated molecule in melanoma metastasis, offering proof-of-concept for a novel strategy to limit this deadly process.
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Precis:A targetable kinase overexpressed in all histological stages of esophageal cancer may provide an important therapeutic target to treat this disease, which while rising in incidence, remains mainly untreatable.
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Precis:The description of a novel truncated form of the ALK receptor shows that genomic rearrangements constitute an alternative mechanism to ALK point mutations, resulting in receptor activation in neuroblastoma, which is of importance in the context of ALK-targeted therapy in neuroblastoma patients.
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Precis:A protein phosphatase subunit responsible for its nuclear targeting is found to bind PTEN and block its tumor suppressor activity.
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Precis:An important stress kinase and its chaperone target appear to play an important role in protecting the liver against long-term ROS damage that promotes chronic inflammation driving formation of most liver cancers.
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Precis:Findings expand our understanding of how cancer cells respond to replication stress, which due to the genomic disorganization of most tumor cells is experienced more acutely in cancer.
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Precis:Results offer proof-of-concept for a tractable approach to inhibit the Snail-Slug signaling pathway of cancer cell invasion by reversing epithelial-mesenchymal transition.
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Precis:Gene expression profiling studies to classify and prognose breast cancer have been disappointing, because they have yielded little if any concordance, but the microarrays used for these studies did not take into account RNA splice variants that may provide more useful gene expression signatures.
Prevention and Epidemiology
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Precis:A predictive DNA repair phenotype measured in peripheral lymphocytes was validated as an independent risk factor for lung cancer, with specific genetic determinants investigated in a two-stage analysis.
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Precis:An assay that can measure the homology-directed repair activity of BRCA2 can predict the cancer pathogenicity of missense mutations in this tumor suppressor gene, possibly impacting the ability to predict cancer susceptibilities in patients harboring those mutations.
Therapeutics, Targets, and Chemical Biology
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Precis:This study defines pharmacodynamic markers to predict responsiveness or resistance to a plethora of experimental clinical agents being developed to therapeutically inhibit the PI3K/Akt/mTOR signaling pathway in cancer.
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Precis:Interrogation of leukemia cells with a kinase inhibitor library allows for computational prediction of kinase pathway dependence and identifies candidate therapies for patients.
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Precis:Blockades to the mechanism by which EGFR targeting is naturally attenuated in vivo have the potential to increase the efficacy of anti-EGFR therapies in clinic.
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Precis:A natural product that targets an RXR-mediated cell survival pathway may offer a new strategy to kill cancer cells.
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Precis:This work reveals that smaller nanoparticles are more effective than larger particles at delivering drugs to tumor cells, with implications for many kinds of cancer nanotherapy studies.
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Precis:Esophageal cancers rising in incidence, possibly due to reductions in gastric H. pylori infections in developed countries, are commonly resistant to cytotoxic chemotherapies that remain a current standard of care.
Tumor and Stem Cell Biology
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Precis:Tumor vascularization mediated by bone marrow-derived vascular progenitor cells relies upon certain microRNAs that may offer novel targets for antiangiogenic therapy.
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Precis:This study reports a model of metastatic cancer that may improve the ability to predict clinical responses to novel therapies against metastatic disease, where there remains the greatest need of accurate predictions for new clinical agents being tested.
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Precis:This study offers a basis to understand the tumor-targeting abilities of mesenchymal stem cells, which have been studied as vectors for the more efficient delivery of cancer gene therapies, with implications for how to best direct their application in this setting.
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Precis:Findings suggest that disruption of pathogenic signals from STAT5 may powerfully disable an aggressive and mainly untreatable leukemia.
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Precis:In defining an E3 ubiquitin ligase as a target for new cancer treatments, this study reveals mechanistic insights into the control of a pivotal cell cycle inhibitor.
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Precis:Granulocyte-macrophage colony-stimulating factor (GM-CSF) is overexpressed in a subset of colon tumors, which when coupled with expression of GM-CSF receptor leads to a strong antitumor activity.
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Precis:This important study suggests that Notch pathway inhibitors may prevent the emergence of drug-resistant cancer stem cells selected by platinum-based chemotherapy, which is used to treat many types of human cancer.
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Precis:This seminal study provides the first evidence for a functional MLL-homeobox transcription factor network that contributes to the stem cell functions supporting glioblastoma tumorigenicity.
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Precis:Findings reveal a novel signaling axis of invasion and metastasis in lung adenocarcinoma that offers therapeutic targets to treat this aggressive disease.
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Precis:Findings identify a prognostic marker and therapeutic target expressed highly selectively in many types of human metastatic tumor cells where COX-2 and PGE-2 levels are elevated.
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Precis:It is increasingly clear that cell senescence cannot be understood simply as a mechanism of tumor suppression in cancer, because it can also promote development of later stages in malignant progression as this study reveals mechanistically.
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Precis:Sophisticated genetic manipulations in the mouse that can finely tune TGF-β expression in the lower gastrointestinal tract can strongly influence the incidence and frequency of tumors formed there.
Correction
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