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Cover 1

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OFC
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Brief Overview of This Month's JACI

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3A-4A
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Table of Contents

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6A-18A
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Editorial Board

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19A
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Reader services
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Information for Readers

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20A
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News & Notes

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22A-24A
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CME Activities Calendar

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25A-26A
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News beyond our pages
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News Beyond Our Pages

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Marc E. Rothenberg, Jean Bousquet 1-2
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Reviews and feature articles
Clinical reviews in allergy and immunology
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Trichuris suis ova: Testing a helminth-based therapy as an extension of the hygiene hypothesis

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Marie-Hélène Jouvin, Jean-Pierre Kinet 3-10
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Continuing Medical Education examination
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Trichuris suis ova: Testing a helminth-based therapy as an extension of the hygiene hypothesis

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11-12
Mechanisms of allergic diseases
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Molecular mechanisms of hookworm disease: Stealth, virulence, and vaccines

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Mark S. Pearson, Leon Tribolet, Cinzia Cantacessi, Maria Victoria Periago, et al. 13-21
Editorials
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The public health benefits of air pollution control

23 April 2012

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Jinghong Li, Gary Ewart, Monica Kraft, Patricia W. Finn 22-23
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Statement regarding “The public health benefits of air pollution control”

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Dennis K. Ledford, A. Wesley Burks, Mark Ballow, Linda Cox, et al. 24
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Task force report
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Adverse reactions to vaccines practice parameter 2012 update

18 May 2012

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John M. Kelso, Matthew J. Greenhawt, James T. Li, Richard A. Nicklas, et al. 25-43
Current perspectives
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Does diversity of environmental microbial exposure matter for the occurrence of allergy and asthma?

16 April 2012

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Dick Heederik, Erika von Mutius 44-50
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The Editors' choice
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The Editors' Choice

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Donald Y.M. Leung, Stanley J. Szefler, Associate Editors of the JACI 51-52
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Asthma and lower airway disease
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Corticosteroid use and bone mineral accretion in children with asthma: Effect modification by vitamin D

18 May 2012

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Sze Man Tse, H. William Kelly, Augusto A. Litonjua, Mark L. Van Natta, et al. 53-60.e4
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Ventilation heterogeneity predicts asthma control in adults following inhaled corticosteroid dose titration

29 March 2012

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Claude S. Farah, Gregory G. King, Nathan J. Brown, Matthew J. Peters, et al. 61-68
Methacholine challenge test: Diagnostic characteristics in asthmatic patients receiving controller medications

02 April 2012

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Kaharu Sumino, Elizabeth A. Sugar, Charles G. Irvin, David A. Kaminsky, et al. 69-75.e6
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Case-control admixture mapping in Latino populations enriches for known asthma-associated genes

16 April 2012

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Dara G. Torgerson, Christopher R. Gignoux, Joshua M. Galanter, Katherine A. Drake, et al. 76-82.e12
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Genome-wide association study of the age of onset of childhood asthma

04 May 2012

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Erick Forno, Jessica Lasky-Su, Blanca Himes, Judie Howrylak, et al. 83-90.e4
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Determinants of asthma after severe respiratory syncytial virus bronchiolitis

26 March 2012

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Leonard B. Bacharier, Rebecca Cohen, Toni Schweiger, Huiquing Yin-DeClue, et al. 91-100.e3
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Why does respiratory syncytial virus appear to cause asthma?

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Darryl J. Adamko, Michael Friesen 101-102
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Novel severe wheezy young children phenotypes: Boys atopic multiple-trigger and girls nonatopic uncontrolled wheeze

16 April 2012

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Jocelyne Just, Rahele Gouvis-Echraghi, Remy Couderc, Nathalie Guillemot-Lambert, et al. 103-110.e8
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Toward a definition of asthma phenotypes in childhood: Making a long way shorter?

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Ulrich Wahn, Paolo M. Matricardi 111-112
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Rhinitis, sinusitis, and upper airway disease
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Intrauterine sensitization of allergen-specific IgE analyzed by a highly sensitive new allergen microarray

01 April 2012

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Norio Kamemura, Hitomi Tada, Naoki Shimojo, Yoshinori Morita,et al. 113-121.e2
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Responses to ragweed pollen in a pollen challenge chamber versus seasonal exposure identify allergic rhinoconjunctivitis endotypes

03 May 2012

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Robert L. Jacobs, Nathan Harper, Weijing He, Charles P. Andrews, et al. 122-127.e8
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Editorial
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Correlation between a pollen challenge chamber and a natural allergen exposure study design for eliciting ocular and nasal symptoms: Early evidence supporting a paradigm shift in drug investigation?

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Jonathan A. Bernstein 128-129
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Atopic dermatitis and skin disease
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Development of atopic dermatitis according to age of onset and association with early-life exposures

23 April 2012

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Caroline Roduit, Remo Frei, Georg Loss, Gisela Büchele,et al. 130-136.e5
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How should an incident case of atopic dermatitis be defined? A systematic review of primary prevention studies

19 March 2012

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Eric L. Simpson, Laura E. Keck, Joanne R. Chalmers, Hywel C. Williams 137-144
IL-17A is essential for cell activation and inflammatory gene circuits in subjects with psoriasis

07 June 2012

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James G. Krueger, Scott Fretzin, Mayte Suárez-Fariñas, Patrick A. Haslett,et al. 145-154.e9
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Correction
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Correction

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154
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Food, drug, insect sting allergy, and anaphylaxis
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Double positivity to bee and wasp venom: Improved diagnostic procedure by recombinant allergen–based IgE testing and basophil activation test including data about cross-reactive carbohydrate determinants

15 March 2012

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Bernadette Eberlein, Lilian Krischan, Ulf Darsow, Markus Ollert, et al. 155-161
Ultrarush versus semirush initiation of insect venom immunotherapy: A randomized controlled trial

29 March 2012

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Simon G.A. Brown, Michael D. Wiese, Pauline van Eeden, Shelley F. Stone, et al. 162-168
Generalized urticaria induced by the Na-ASP-2 hookworm vaccine: Implications for the development of vaccines against helminths

28 May 2012

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David J. Diemert, Antonio G. Pinto, Janaina Freire, Amar Jariwala, et al. 169-176.e6
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Immune deficiencies, infection, and systemic immune disorders
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Defining combined immunodeficiency

04 June 2012

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Chaim M. Roifman, Raz Somech, Fotini Kavadas, Linda Pires, et al. 177-183
Mechanisms of allergy and clinical immunology
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A critical role of IL-33 in experimental allergic rhinitis

29 March 2012

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Yoko Haenuki, Kazufumi Matsushita, Shizue Futatsugi-Yumikura, Ken J. Ishii, et al. 184-194.e11
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Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1–dependent pathways

23 April 2012

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Victoria J. Philbin, David J. Dowling, Leighanne C. Gallington, Guadalupe Cortés, et al. 195-204.e9
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Mast cell TNF receptors regulate responses to Mycoplasma pneumoniae in surfactant protein A (SP-A)−/− mice

16 April 2012

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Bethany J. Hsia, Julie G. Ledford, Erin N. Potts-Kant, Vinayak S. Nikam, et al. 205-214.e2
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Epigenetic modifications and improved regulatory T-cell function in subjects undergoing dual sublingual immunotherapy

07 June 2012

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Ravi S. Swamy, Neha Reshamwala, Tessa Hunter, Soujanya Vissamsetti, et al. 215-224.e7
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Airway epithelial cells activate TH2 cytokine production in mast cells through IL-1 and thymic stromal lymphopoietin

28 May 2012

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Deepti R. Nagarkar, Julie A. Poposki, Michael R. Comeau, Assel Biyasheva,et al. 225-232.e4
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Multiple-checkpoint inhibition of thymic stromal lymphopoietin–induced TH2 response by TH17-related cytokines

04 June 2012

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Sofia I. Bogiatzi, Maude Guillot-Delost, Antonio Cappuccio, Jean-Christophe Bichet, et al. 233-240.e5
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Alternaria alternata allergen Alt a 1: A unique β-barrel protein dimer found exclusively in fungi

04 June 2012

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Maksymilian Chruszcz, Martin D. Chapman, Tomasz Osinski, Robert Solberg,et al. 241-247.e9
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Molecular mimicry between cockroach and helminth glutathione S-transferases promotes cross-reactivity and cross-sensitization

27 April 2012

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Helton C. Santiago, Elyse LeeVan, Sasisekhar Bennuru, Flavia Ribeiro-Gomes,et al. 248-256.e9
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Editorial
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Parasites and allergic disease: Another piece of the puzzle

14 May 2012

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Robert K. Bush 257-258
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Letters to the Editor
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TH2 cytokines increase kallikrein 7 expression and function in patients with atopic dermatitis

23 April 2012

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Shin Morizane, Kenshi Yamasaki, Ai Kajita, Kazuko Ikeda, et al. 259-261.e1
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Accurate oral food challenge requires a cumulative dose on a subsequent day

02 May 2012

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Bodo Niggemann, Lars Lange, Antje Finger, Mandy Ziegert, et al. 261-263
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A self-regulation intervention can improve quality of life for families with food allergy

30 April 2012

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Alan P. Baptist, Sara I. Dever, Matthew J. Greenhawt, Nancy Polmear-Swendris, et al. 263-265.e6
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Ascaris sensitization is associated with aeroallergen sensitization and airway hyperresponsiveness but not allergic disease in urban Africa

04 May 2012

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Michael Levin, Rudzani Muloiwa, Peter Le Souëf, Cassim Motala 265-267
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Fungal and atopic sensitization are low among farmers in the Agricultural Health Study

28 May 2012

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Stacy M. Endres, Brett J. Green, Paul K. Henneberger, Dori R. Germolec, et al. 267-270.e1
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Helminth infection is associated with decreased basophil responsiveness in human beings

18 May 2012

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David Larson, Philip J. Cooper, Marc P. Hübner, Jorge Reyes, et al. 270-272
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Human CD20+CD43+CD27+CD5 B cells generate antibodies to capsular polysaccharides of Streptococcus pneumoniae

04 June 2012

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Bert Verbinnen, Kris Covens, Leen Moens, Isabelle Meyts, et al. 272-275
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Correspondence
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Comparable IgE reactivity to natural and recombinant Api m 1 in cross-reactive carbohydrate determinant–negative patients with bee venom allergy

28 May 2012

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Thilo Jakob, Julian Köhler, Simon Blank, Ulrika Magnusson, et al. 276-278
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Reply

28 May 2012

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Peter Korošec, Mitja Košnik 278-279
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Possible roles of 2 basidiomycetous fungi in allergic fungal respiratory disease

28 May 2012

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Haruhiko Ogawa, Masaki Fujimura, Yasuo Takeuchi, Koichi Makimura 279-280
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28 May 2012

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Alan P. Knutsen, Robert K. Bush 280
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Basophil activation test and autologous serum skin test: Not overlapping tests in chronic urticaria

28 May 2012

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Alberto Tedeschi, Riccardo Asero, Massimo Cugno 280-281
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Reply

04 June 2012

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Thomas Gentinetta, Werner J. Pichler, Oliver V. Hausmann 281
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Correction
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282
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Maintenance of Certification clinical management series
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Vaccines in the assessment of patients for immune deficiency

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Mark Ballow 283-284.e5
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