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Pages 87-88
Nicola Bizzaro
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2  

Tools for critical appraisal of evidence in studies of diagnostic accuracy

 Review Article
Pages 89-96
Davide Giavarina
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3  

Are anti-nucleosome antibodies a better diagnostic marker than anti-dsDNA antibodies for systemic lupus erythematosus? A systematic review and a study of metanalysis

 Review Article
Pages 97-106
Nicola Bizzaro, Danilo Villalta, Davide Giavarina, Renato Tozzoli
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4  

TSH receptor autoantibody immunoassay in patients with Graves' disease: Improvement of diagnostic accuracy over different generations of methods. Systematic review and meta-analysis

Review Article
Pages 107-113
R. Tozzoli, M. Bagnasco, D. Giavarina, N. Bizzaro
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5  

Diagnostic accuracy and predictive value of extended autoantibody profile in systemic sclerosis

Review Article
Pages 114-120
Danilo Villalta, Tiziana Imbastaro, Sabrina Di Giovanni, Ciro Lauriti, Marco Gabini, Maria Costanza Turi, Nicola Bizzaro
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6  

Diagnostic accuracy of enzyme-linked immunosorbent assays (ELISA) to detect anti-skin autoantibodies in autoimmune blistering skin diseases: A systematic review and meta-analysis

Review Article
Pages 121-126
Marilina Tampoia, Davide Giavarina, Chiara Di Giorgio, Nicola Bizzaro
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7  

Can supplementation with vitamin D reduce the risk or modify the course of autoimmune diseases? A systematic review of the literature

 Review Article
Pages 127-136
Antonio Antico, Marilina Tampoia, Renato Tozzoli, Nicola Bizzaro
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Review Papers
8  

Antinuclear antibody detection by automated multiplex immunoassay in untreated patients at the time of diagnosis

 Review Article
Pages 137-143
Katrijn Op De Beéck, Pieter Vermeersch, Patrick Verschueren, René Westhovens, Godelieve Mariën, Daniel Blockmans, Xavier Bossuyt
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Supplementary content 

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Highlights

► Likelihood ratios (LR) help with the interpretation of multiplex immunoassays. ► Test result interval specific LR increase with increasing antibody concentration. ► The presence of multiple antibodies is specific for systematic rheumatic disease.
9  

Immune-mediated myelitis following hepatitis B vaccination

 Review Article
Pages 144-149
Joerg-Patrick Stübgen
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10  

The role of T cell apoptosis in nervous system autoimmunity

 Review Article
Pages 150-156
C. Comi, T. Fleetwood, U. Dianzani
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11  

Systemic lupus erythematosus and infections: Clinical importance of conventional and upcoming biomarkers

 Review Article
Pages 157-163
S. Sciascia, L. Ceberio, C. Garcia-Fernandez, D. Roccatello, Y. Karim, M.J. Cuadrado
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12  

The perioperative use of biologic agents in patients with rheumatoid arthritis

 Review Article
Pages 164-168
Ari Polachek, Dan Caspi, Ori Elkayam
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13  

Anti-glomerular basement membrane antibody disease: A rare autoimmune disorder affecting the kidney and the lung

 Review Article
Pages 169-173
Tobias Lahmer, Uwe Heemann
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Highlights

► Rare autoimmune disorder which affects the kidney and the lungs. ► Detectable by specific serum antibodies or histological specimen. ► Standard treatment consists of plasmapherisis, prednisolone and cyclophosphamide.
14  

Lupus nephritis: A critical review

 Review Article
Pages 174-194
Andrea T. Borchers, Naama Leibushor, Stanley M. Naguwa, Gurtej S. Cheema, Yehuda Shoenfeld, M. Eric Gershwin
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15  

Induction of antigen-specific tolerance through hematopoietic stem cell-mediated gene therapy: The future for therapy of autoimmune disease?

 Review Article
Pages 195-203
Miranda A. Coleman, Raymond J. Steptoe
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16  

The Relapsing Polychondritis Disease Activity Index: Development of a disease activity score for relapsing polychondritis

 Review Article
Pages 204-209
Laurent Arnaud, Hervé Devilliers, Stanford L. Peng, Alexis Mathian, Nathalie Costedoat-Chalumeau, Jane Buckner, Lorenzo Dagna, Clement Michet, Aman Sharma, Ricard Cervera, Julien Haroche, Thomas Papo, David D'Cruz, Philippe Arlet, Jochen Zwerina, Alexandre Belot, Noboru Suzuki, Jean-Robert Harle, Robert Moots, David Jayne, et al.
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17  

Hierarchical cluster and survival analyses of antisynthetase syndrome: Phenotype and outcome are correlated with anti-tRNA synthetase antibody specificity

 Review Article
Pages 210-217
Baptiste Hervier, Hervé Devilliers, Raluca Stanciu, Alain Meyer, Yurdagul Uzunhan, Agathe Masseau, Sylvain Dubucquoi, Pierre-Yves Hatron, Lucile Musset, Benoit Wallaert, Hilario Nunes, Thierry Maisonobe, Nils-Olivier Olsson, Daniel Adoue, Philippe Arlet, Jean Sibilia, Marguerite Guiguet, Dominique Lauque, Zahir Amoura, Eric Hachulla, et al.
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18  

Exercise as a therapeutic tool to counteract inflammation and clinical symptoms in autoimmune rheumatic diseases

 Review Article
Pages 218-224
Luiz Augusto Perandini, Ana Lúcia de Sá-Pinto, Hamilton Roschel, Fabiana Braga Benatti, Fernanda Rodrigues Lima, Eloisa Bonfá, Bruno Gualano
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19  

Long-term anti-TNF therapy and the risk of serious infections in a cohort of patients with rheumatoid arthritis: Comparison of adalimumab, etanercept and infliximab in the GISEA registry

Review Article
Pages 225-229
Fabiola Atzeni, Piercarlo Sarzi-Puttini, Costantino Botsios, Antonio Carletto, Paola Cipriani, Ennio Giulio Favalli, Elena Frati, Valentina Foschi, Stefania Gasparini, AnnaRita Giardina, Elisa Gremese, Florenzo Iannone, Marco Sebastiani, Tamara Ziglioli, Domenico Biasi, Clodoveo Ferri, Mauro Galeazzi, Roberto Gerli, Roberto Giacomelli, Roberto Gorla, et al.
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20  

Anti-phosphatidylethanolamine antibody, thromboembolic events and the antiphospholipid syndrome

 Review Article
Pages 230-234
Henrique Luiz Staub, Maria Laura Bertolaccini, Munther A. Khamashta
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21  

Churg–Strauss Syndrome: An evolving paradigm

 Review Article
Pages 235-240
Marc Ramentol-Sintas, Fernando Martínez-Valle, Roser Solans-Laqué
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22  

β2-glycoprotein I and oxidative inflammation in early atherogenesis: A progression from innate to adaptive immunity?

 Review Article
Pages 241-249
Eiji Matsuura, Luis R. Lopez, Yehuda Shoenfeld, Paul R.J. Ames
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23  

Autonomic dysfunction: A unifying multiple sclerosis theory, linking chronic cerebrospinal venous insufficiency, vitamin D3, and Epstein-Barr virus

 Review Article
Pages 250-259
Zohara Sternberg
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24  

Asialoglycoprotein receptor (ASGPR) as target autoantigen in liver autoimmunity: Lost and found

Review Article
Pages 260-269
Eirini I. Rigopoulou, Dirk Roggenbuck, Daniel S. Smyk, Christos Liaskos, Maria G. Mytilinaiou, Eugen Feist, Karsten Conrad, Dimitrios P. Bogdanos
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Highlights

► Asialoglycoprotein receptor (ASGPR) is a liver-specific autoantigen. ► A reliable test for anti-ASGPR antibodies has not been developed. ► Recent ELISA may allow efficient anti-ASGPR antibody testing. ► Anti-ASGPR antibodies are most prevalent in autoimmune hepatitis. ► ASGPR autoantibodies identify AIH patients with active disease.
25  

Haplotype specific alteration of diabetes MHC risk by olfactory receptor gene polymorphism

Review Article
Pages 270-274
Mohamed M. Jahromi
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26  

Intravenous immunoglobulin for the treatment of Crohn's disease

 Review Article
Pages 275-280
Moshe Rogosnitzky, Rachel Danks, Daniel Holt
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Highlights

► There is an urgent need for alternatives to anti-TNF drugs in Crohn's disease (CD). ► IVIG has been used in CD for years, although few data, and no RCTS, are published. ► A literature review shows that IVIG can induce rapid improvement in CD within days. ► Longer-term data show that maintenance of remission over the medium term is possible. ► Verification is needed from large RCTs to show the safety and efficacy of IVIG in CD.
27  

The putative role of endoplasmic reticulum aminopeptidases in autoimmunity: Insights from genomic-wide association studies

 Review Article
Pages 281-288
Alessandra Fierabracci, Annamaria Milillo, Franco Locatelli, Doriana Fruci
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28  

Venous thromboembolic disease in systemic autoimmune diseases: An association to keep in mind

 Review Article
Pages 289-294
Ricardo Silvariño, Álvaro Danza, Valentina Mérola, Adriana Bérez, Enrique Méndez, Gerard Espinosa, Ricard Cervera
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29  

What is the key environmental trigger in type 1 diabetes — Is it viruses, or wheat gluten, or both?

Review Article
Pages 295-299
William E. Barbeau
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30  

Th17 and regulatory T lymphocytes in primary biliary cirrhosis and systemic sclerosis as models of autoimmune fibrotic diseases

 Review Article
Pages 300-304
Daniela Fenoglio, Francesca Bernuzzi, Florinda Battaglia, Alessia Parodi, Francesca Kalli, Simone Negrini, Raffaele De Palma, Pietro Invernizzi, Gilberto Filaci
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31  

Multimodality imaging and the emerging role of cardiac magnetic resonance in autoimmune myocarditis

 Review Article
Pages 305-312
Sophie Mavrogeni, Theodoros Dimitroulas, George D. Kitas
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32  

Autoantibodies to domain 1 of beta 2 glycoprotein 1: A promising candidate biomarker for risk management in antiphospholipid syndrome

 Review Article
Pages 313-317
Michael Mahler, Gary L. Norman, Pier Luigi Meroni, Munther Khamashta
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33  

Closing the serological gap: promising novel biomarkers for the early diagnosis of rheumatoid arthritis

 Review Article
Pages 318-322
Leendert A. Trouw, Michael Mahler
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34  

Bell's palsy and autoimmunity

 Review Article
Pages 323-328
A. Greco, A. Gallo, M. Fusconi, C. Marinelli, G.F. Macri, M. de Vincentiis
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35  

Biologic registries in rheumatology: Lessons learned and expectations for the future

Review Article
Pages 329-336
Ori Elkayam, Karel Pavelka
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