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Invited Review
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Neuroinflammation after traumatic brain injury: Opportunities for therapeutic intervention

Review Article
Pages 1191-1201
Alok Kumar, David J. Loane
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► Neuroinflammation is a key secondary injury mechanism following traumatic brain injury, and selective inhibition of these pathways result in significant neuroprotection.
Named Series: Fatigue, Brain, Behavior, and Immunity
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Biomarkers for chronic fatigue

 Review Article
Pages 1202-1210
Nancy G. Klimas, Gordon Broderick, Mary Ann Fletcher
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Fatigue symptoms relate to systemic inflammation in patients with type 2 diabetes

 Review Article
Pages 1211-1219
Julie Lasselin, Sophie Layé, Sandra Dexpert, Agnès Aubert, Concepcion Gonzalez, Henri Gin, Lucile Capuron
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► Low grade inflammation associates with fatigue symptoms in type 2 diabetic patients suggesting the role of immune processes in the pathophysiology of diabetes-related fatigue.
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Fatigue, brain, behavior, and immunity: Summary of the 2012 Named Series on fatigue

 Review Article
Pages 1220-1223
Julienne E. Bower
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Brief Commentary
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Can we really know if a stressor increases or decreases natural killer cell activity?


Pages 1224-1225
Shamgar Ben-Eliyahu
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Regular Article
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β-Adrenergic receptor mediated increases in activation and function of natural killer cells following repeated social disruption

 Original Research Article
Pages 1226-1238
Andrew J. Tarr, Nicole D. Powell, Brenda F. Reader, Neela S. Bhave, Amanda L. Roloson, William E. Carson 3rd, John F. Sheridan
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► Social disruption increases natural killer cell activation, degranulation potential, and anti-viral cytokine production in the absence of infection.
Short Communications
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Elevated C-reactive protein is associated with severe periodic leg movements of sleep in patients with restless legs syndrome


Pages 1239-1243
Lynn Marie Trotti, David B. Rye, Christine De Staercke, W. Craig Hooper, Arshed Quyyumi, Donald L. Bliwise
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► Patients with restless legs syndrome who have frequent periodic leg movements of sleep are more likely to have elevated levels of C-reactive protein, but not IL-6 or TNF-alpha.
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Increased soluble interleukin-2 receptor levels are related to somatic but not to cognitive-affective features in major depression


Pages 1244-1248
Frank Euteneuer, Markus J. Schwarz, Katharina Dannehl, Anja Hartung, Stefan Westermann, Winfried Rief
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► Increased sIL-2R levels are related to somatoform symptoms and somatic anxiety symptoms but not to cognitive-affective features in major depression.
Regular Articles
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Repeated stressor exposure regionally enhances beta-adrenergic receptor-mediated brain IL-1β production

 Original Research Article
Pages 1249-1255
Veronica M. Porterfield, Kristin M. Gabella, Mark A. Simmons, John D. Johnson
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► Repeated stressor exposure results in brain area specific enhancement in β-adrenergic-mediated IL-1β production.
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Prior exposure to repeated morphine potentiates mechanical allodynia induced by peripheral inflammation and neuropathy

 Original Research Article
Pages 1256-1264
Lisa C. Loram, Peter M. Grace, Keith A. Strand, Frederick R. Taylor, Amanda Ellis, Debra Berkelhammer, Melissa Bowlin, Bryce Skarda, Steven F. Maier, Linda R. Watkins
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► Morphine dosing for five days potentiates subsequent neuroinflammation and mechanical allodynia from hindpaw inflammation, hindlimb neuropathy and orofacial inflammation.
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Fish oil supplementation augments post-exercise immune function in young males

Original Research Article
Pages 1265-1272
Patrick Gray, Brendan Gabriel, Frank Thies, Stuart R. Gray
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► Fish oil supplementation augments post-exercise NK cell activity and PBMC IL-2 production.
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Different distribution patterns of lymphocytes and microglia in the hippocampus of patients with residual versus paranoid schizophrenia: Further evidence for disease course-related immune alterations?

 Original Research Article
Pages 1273-1279
Stefan Busse, Mandy Busse, Kolja Schiltz, Hendrik Bielau, Tomasz Gos, Ralf Brisch, Christian Mawrin, Andrea Schmitt, Wolfgang Jordan, Ulf J. Müller, Hans-Gert Bernstein, Bernhard Bogerts, Johann Steiner
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► Increased lymphocyte densities were identified in the hippocampus of patients with residual schizophrenia in contrast to increased microglia in paranoid schizophrenia.
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Epstein-Barr virus reactivation during pregnancy and postpartum: Effects of race and racial discrimination

 Original Research Article
Pages 1280-1287
Lisa M. Christian, Jay D. Iams, Kyle Porter, Ronald Glaser
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► Compared to Whites, African–Americans exhibit higher Epstein-Barr virus antibody titers in pregnancy and postpartum, particularly those reporting greater racial discrimination.
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Behaviour and hippocampus-specific changes in spiny mouse neonates after treatment of the mother with the viral-mimetic Poly I:C at mid-pregnancy

 Original Research Article
Pages 1288-1299
Udani Ratnayake, Tracey A. Quinn, Margie Castillo-Melendez, Hayley Dickinson, David W. Walker
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► Behavioural deficits and neurological abnormalities in spiny mouse offspring prenatally exposed to the viral-mimetic Poly I:C.
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Effects on secretory IgA levels in small intestine of mice that underwent moderate exercise training followed by a bout of strenuous swimming exercise

 Original Research Article
Pages 1300-1309
Marycarmen Godínez-Victoria, Ma. Elisa Drago-Serrano, Humberto Reyna-Garfias, Maria Viloria, Eleazar Lara-Padilla, Aldo A. Resendiz-Albor, Luvia E. Sánchez-Torres, Teresita R. Cruz-Hernández, Rafael Campos-Rodriguez
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► Strenuous exercise after training elicited higher pool-derived levels of SIgA and pIgR in small intestine than strenuous exercise without training.
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Administration of palmitoylethanolamide (PEA) protects the neurovascular unit and reduces secondary injury after traumatic brain injury in mice

 Original Research Article
Pages 1310-1321
Akbar Ahmad, Rosalia Crupi, Daniela Impellizzeri, Michela Campolo, Angela Marino, Emanuela Esposito, Salvatore Cuzzocrea
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► The manuscript explores the molecular pathways involved in the protective effect of palmitoylethanolamide in a model of traumatic brain injury.
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Neuro-protective effects of bee venom by suppression of neuroinflammatory responses in a mouse model of Parkinson’s disease: Role of regulatory T cells

 Original Research Article
Pages 1322-1330
Eun Sook Chung, Himchan Kim, Gihyun Lee, Soojin Park, Hyunseong Kim, Hyunsu Bae
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► This work shows that the neuro-protective effect of BV is associated with its antiinflammatory properties in the brain and modulation of peripheral immune tolerance by Tregs.
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Postnatal administration of IL-1Ra exerts neuroprotective effects following perinatal inflammation and/or hypoxic-ischemic injuries

 Original Research Article
Pages 1331-1339
Sylvie Girard, Hugues Sébire, Marie-Elsa Brochu, Sinziana Briota, Philippe Sarret, Guillaume Sébire
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► Using a rat model of perinatal brain injury, we showed that postnatal IL-1Ra, anti-inflammatory treatment, was protective against behavioral deficits and brain injury.