A conversation with Francis Collins *
Ushma S. Neill
Full text | PDF (Page 3797)
Molecular pathogenesis and clinical management of Fanconi anemia *
Younghoon Kee, Alan D. D’Andrea
Abstract | Full text | PDF (Page 3799)
Lymphangioleiomyomatosis — a wolf in sheep’s clothing *
Elizabeth P. Henske, Francis X. McCormack
Abstract | Full text | PDF (Page 3807)
Perspectives on whole-organ assembly: moving toward transplantation on demand *
Alejandro Soto-Gutierrez, Jason A. Wertheim, Harald C. Ott, Thomas W. Gilbert
Abstract | Full text | PDF (Page 3817)
Advances in stem cell therapy for spinal cord injury *
Andrea J. Mothe, Charles H. Tator
Abstract | Full text | PDF (Page 3824)
Autoantibodies, autoimmune disease, and the birth of immune diagnostics *
Eng M. Tan
Abstract | Full text | PDF (Page 3835)
Genetic “lnc”-age of noncoding RNAs to human disease *
Andrew Troy, Norman E. Sharpless
Abstract | Full text | PDF (Page 3837)
Tipping the scales early: probing the long-term effects of obesity *
Chen Liu, Joel K. Elmquist
Abstract | Full text | PDF (Page 3840)
Micro-editing mistake translates into a devastating brain tumor *
Dan Dominissini, Ninette Amariglio, Gideon Rechavi
Abstract | Full text | PDF (Page 3842)
Lung capillaries raise the hypoxia alarm *
Jahar Bhattacharya
Abstract | Full text | PDF (Page 3845)
The bitter taste of infection *
Alice Prince
Abstract | Full text | PDF (Page 3847)
Turning a blind eye to anti-VEGF toxicities *
Susan E. Quaggin
Abstract | Full text | PDF (Page 3849)
The promise of immune cell therapy for acute kidney injury *
Hamid Rabb
Abstract | Full text | PDF (Page 3852)
New mechanisms of glucocorticoid-induced insulin resistance: make no bones about it *
Heather A. Ferris, C. Ronald Kahn
Abstract | Full text | PDF (Page 3854)
Amazing IL-9: revealing a new function for an “old” cytokine *
Edgar Schmitt, Tobias Bopp
Abstract | Full text | PDF (Page 3857)
Endoplasmic reticulum stress and hypertension — a new paradigm? *
Alyssa H. Hasty, David G. Harrison
Abstract | Full text | PDF (Page 3859)
Mesodermal Pten inactivation leads to alveolar capillary dysplasia-like phenotype
Caterina Tiozzo, Gianni Carraro, Denise Al Alam, Sheryl Baptista, Soula Danopoulos, Aimin Li, Maria Lavarreda-Pearce, Changgong Li, Stijn De Langhe, Belinda Chan, Zea Borok, Saverio Bellusci, Parviz Minoo
Abstract | Full text | PDF | Supplemental material (Page 3862)
HEXIM1 controls satellite cell expansion after injury to regulate skeletal muscle regeneration
Peng Hong, Kang Chen, Bihui Huang, Min Liu, Miao Cui, Inna Rozenberg, Brahim Chaqour, Xiaoyue Pan, Elisabeth R. Barton, Xian-Cheng Jiang, M.A.Q. Siddiqui
Abstract | Full text | PDF | Supplemental material (Page 3873)
Spleens of myelofibrosis patients contain malignant hematopoietic stem cells
Xiaoli Wang, Sonam Prakash, Min Lu, Joseph Tripodi, Fei Ye, Vesna Najfeld, Yan Li, Myron Schwartz, Rona Weinberg, Paul Roda, Attilio Orazi, Ronald Hoffman
Abstract | Full text | PDF | Supplemental material (Page 3888)
Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes
Esther Fuente-Martín, Cristina García-Cáceres, Miriam Granado, María L. de Ceballos, Miguel Ángel Sánchez-Garrido, Beatrix Sarman, Zhong-Wu Liu, Marcelo O. Dietrich, Manuel Tena-Sempere, Pilar Argente-Arizón, Francisca Díaz, Jesús Argente, Tamas L. Horvath, Julie A. Chowen
Abstract | Full text | PDF | Supplemental material (Page 3900)
Brief Report Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes
Sayaka Sekiya, Atsushi Suzuki
Abstract | Full text | PDF | Supplemental material (Page 3914)
Ceramide synthase 5 mediates lipid-induced autophagy and hypertrophy in cardiomyocytes
Sarah Brice Russo, Catalin F. Baicu, An Van Laer, Tuoyu Geng, Harinath Kasiganesan, Michael R. Zile, L. Ashley Cowart
Abstract | Full text | PDF | Supplemental material (Page 3919)
Dendritic cells tolerized with adenosine A2AR agonist attenuate acute kidney injury
Li Li, Liping Huang, Hong Ye, Steven P. Song, Amandeep Bajwa, Sang Ju Lee, Emily K. Moser, Katarzyna Jaworska, Gilbert R. Kinsey, Yuan J. Day, Joel Linden, Peter I. Lobo, Diane L. Rosin, Mark D. Okusa
Abstract | Full text | PDF | Supplemental material (Page 3931)
Scavenger receptors target glycolipids for natural killer T cell activation
Stefan Freigang, Elise Landais, Victoria Zadorozhny, Lisa Kain, Kenji Yoshida, Yang Liu, Shenglou Deng, Wulf Palinski, Paul B. Savage, Albert Bendelac, Luc Teyton
Abstract | Full text | PDF | Supplemental material (Page 3943)
Brief Report Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury
Lauren Herl Martens, Jiasheng Zhang, Sami J. Barmada, Ping Zhou, Sherry Kamiya, Binggui Sun, Sang-Won Min, Li Gan, Steven Finkbeiner, Eric J. Huang, Robert V. Farese Jr.
Abstract | Full text | PDF | Supplemental material (Page 3955)
Brief Report ER stress in the brain subfornical organ mediates angiotensin-dependent hypertension
Colin N. Young, Xian Cao, Mallikarjuna R. Guruju, Joseph P. Pierce, Donald A. Morgan, Gang Wang, Costantino Iadecola, Allyn L. Mark, Robin L. Davisson
Abstract | Full text | PDF | Supplemental material (Page 3960)
Psoriasiform dermatitis is driven by IL-36–mediated DC-keratinocyte crosstalk
Luigi Tortola, Esther Rosenwald, Brian Abel, Hal Blumberg, Matthias Schäfer, Anthony J. Coyle, Jean-Christoph Renauld, Sabine Werner, Jan Kisielow, Manfred Kopf
Abstract | Full text | PDF | Supplemental material (Page 3965)
PSD-95 expression controls l-DOPA dyskinesia through dopamine D1 receptor trafficking
Gregory Porras, Amandine Berthet, Benjamin Dehay, Qin Li, Laurent Ladepeche, Elisabeth Normand, Sandra Dovero, Audrey Martinez, Evelyne Doudnikoff, Marie-Laure Martin-Négrier, Qin Chuan, Bertrand Bloch, Daniel Choquet, Eric Boué-Grabot, Laurent Groc, Erwan Bezard
Abstract | Full text | PDF | Supplemental material (Page 3977)
A misplaced lncRNA causes brachydactyly in humans
Philipp G. Maass, Andreas Rump, Herbert Schulz, Sigmar Stricker, Lisanne Schulze, Konrad Platzer, Atakan Aydin, Sigrid Tinschert, Mary B. Goldring, Friedrich C. Luft, Sylvia Bähring
Abstract | Full text | PDF | Supplemental material (Page 3990)
HELLP babies link a novel lincRNA to the trophoblast cell cycle
Marie van Dijk, Hari K. Thulluru, Joyce Mulders, Omar J. Michel, Ankie Poutsma, Sandra Windhorst, Gunilla Kleiverda, Daoud Sie, Augusta M.A. Lachmeijer, Cees B.M. Oudejans
Abstract | Full text | PDF | Supplemental material (Page 4003)
Technical Advance A novel murine infection model for Shiga toxin–producing Escherichia coli
Emily M. Mallick, Megan E. McBee, Vijay K. Vanguri, Angela R. Melton-Celsa, Katherine Schlieper, Brad J. Karalius, Alison D. O’Brien, Joan R. Butterton, John M. Leong, David B. Schauer
Abstract | Full text | PDF | Supplemental material (Page 4012)
Protease nexin 1 inhibits hedgehog signaling in prostate adenocarcinoma
Chad M. McKee, Danmei Xu, Yunhong Cao, Sheheryar Kabraji, Danny Allen, Veerle Kersemans, John Beech, Sean Smart, Freddie Hamdy, Adrian Ishkanian, Jenna Sykes, Melania Pintile, Michael Milosevic, Theodorus van der Kwast, Gaetano Zafarana, Varune Rohan Ramnarine, Igor Jurisica, Chad Mallof, Wan Lam, Robert G. Bristow, Ruth J. Muschel
Abstract | Full text | PDF | Supplemental material (Page 4025)
Cross-presenting CD103+ dendritic cells are protected from influenza virus infection
Julie Helft, Balaji Manicassamy, Pierre Guermonprez, Daigo Hashimoto, Aymeric Silvin, Judith Agudo, Brian D. Brown, Mirco Schmolke, Jennifer C. Miller, Marylene Leboeuf, Kenneth M. Murphy, Adolfo García-Sastre, Miriam Merad
Abstract | Full text | PDF | Supplemental material (Page 4037)
AFG3L2 supports mitochondrial protein synthesis and Purkinje cell survival
Eva R. Almajan, Ricarda Richter, Lars Paeger, Paola Martinelli, Esther Barth, Thorsten Decker, Nils-Göran Larsson, Peter Kloppenburg, Thomas Langer, Elena I. Rugarli
Abstract | Full text | PDF | Supplemental material (Page 4048)
Attenuated adenosine-to-inosine editing of microRNA-376a* promotes invasiveness of glioblastoma cells
Yukti Choudhury, Felix Chang Tay, Dang Hoang Lam, Edwin Sandanaraj, Carol Tang, Beng-Ti Ang, Shu Wang
Abstract | Full text | PDF | Supplemental material (Page 4059)
Nanog signaling in cancer promotes stem-like phenotype and immune evasion
Kyung Hee Noh, Bo Wook Kim, Kwon-Ho Song, Hanbyoul Cho, Young-Ho Lee, Jin Hee Kim, Joon-Yong Chung, Jae-Hoon Kim, Stephen M. Hewitt, Seung-Yong Seong, Chih-Ping Mao, T.-C. Wu, Tae Woo Kim
Abstract | Full text | PDF | Supplemental material (Page 4077)
TNF signaling drives myeloid-derived suppressor cell accumulation
Xueqiang Zhao, Lijie Rong, Xiaopu Zhao, Xiao Li, Xiaoman Liu, Jingjing Deng, Hao Wu, Xia Xu, Ulrike Erben, Peihua Wu, Uta Syrbe, Joachim Sieper, Zhihai Qin
Abstract | Full text | PDF | Supplemental material (Page 4094)
PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice
José Iglesias, Sebastian Barg, David Vallois, Shawon Lahiri, Catherine Roger, Akadiri Yessoufou, Sylvain Pradevand, Angela McDonald, Claire Bonal, Frank Reimann, Fiona Gribble, Marie-Bernard Debril, Daniel Metzger, Pierre Chambon, Pedro Herrera, Guy A. Rutter, Marc Prentki, Bernard Thorens, Walter Wahli
Abstract | Full text | PDF | Supplemental material (Page 4105)
Toll-like receptor 7 regulates pancreatic carcinogenesis in mice and humans
Atsuo Ochi, Christopher S. Graffeo, Constantinos P. Zambirinis, Adeel Rehman, Michael Hackman, Nina Fallon, Rocky M. Barilla, Justin R. Henning, Mohsin Jamal, Raghavendra Rao, Stephanie Greco, Michael Deutsch, Marco V. Medina-Zea, Usama Bin Saeed, Melvin O. Ego-Osuala, Cristina Hajdu, George Miller
Abstract | Full text | PDF | Supplemental material (Page 4118)
Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis
John Zhong Li, Yongcheng Huang, Ruchan Karaman, Pavlina T. Ivanova, H. Alex Brown, Thomas Roddy, Jose Castro-Perez, Jonathan C. Cohen, Helen H. Hobbs
Abstract | Full text | PDF | Supplemental material (Page 4130)
T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection
Robert J. Lee, Guoxiang Xiong, Jennifer M. Kofonow, Bei Chen, Anna Lysenko, Peihua Jiang, Valsamma Abraham, Laurel Doghramji, Nithin D. Adappa, James N. Palmer, David W. Kennedy, Gary K. Beauchamp, Paschalis-Thomas Doulias, Harry Ischiropoulos, James L. Kreindler, Danielle R. Reed, Noam A. Cohen
Abstract | Full text | PDF | Supplemental material (Page 4145)
Th9 cells promote antitumor immune responses in vivo
Yong Lu, Sungyoul Hong, Haiyan Li, Jungsun Park, Bangxing Hong, Lijuan Wang, Yuhuan Zheng, Zhiqiang Liu, Jingda Xu, Jin He, Jing Yang, Jianfei Qian, Qing Yi
Abstract | Full text | PDF | Supplemental material (Page 4160)
Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism
Tara C. Brennan-Speranza, Holger Henneicke, Sylvia J. Gasparini, Katharina I. Blankenstein, Uta Heinevetter, Victoria C. Cogger, Dmitri Svistounov, Yaqing Zhang, Gregory J. Cooney, Frank Buttgereit, Colin R. Dunstan, Caren Gundberg, Hong Zhou, Markus J. Seibel
Abstract | Full text | PDF | Supplemental material (Page 4172)
MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages
Maliheh Nazari-Jahantigh, Yuanyuan Wei, Heidi Noels, Shamima Akhtar, Zhe Zhou, Rory R. Koenen, Kathrin Heyll, Felix Gremse, Fabian Kiessling, Jochen Grommes, Christian Weber, Andreas Schober
Abstract | Full text | PDF | Supplemental material (Page 4190)
Obesity-programmed mice are rescued by early genetic intervention
Viviana F. Bumaschny, Miho Yamashita, Rodrigo Casas-Cordero, Verónica Otero-Corchón, Flávio S.J. de Souza, Marcelo Rubinstein, Malcolm J. Low
Abstract | Full text | PDF | Supplemental material (Page 4203)
Brief Report Targeted deletion of Vegfa in adult mice induces vision loss
Toshihide Kurihara, Peter D. Westenskow, Stephen Bravo, Edith Aguilar, Martin Friedlander
Abstract | Full text | PDF | Supplemental material (Page 4213)
Hypoxic pulmonary vasoconstriction requires connexin 40–mediated endothelial signal conduction
Liming Wang, Jun Yin, Hannah T. Nickles, Hannes Ranke, Arata Tabuchi, Julia Hoffmann, Christoph Tabeling, Eduardo Barbosa-Sicard, Marc Chanson, Brenda R. Kwak, Hee-Sup Shin, Songwei Wu, Brant E. Isakson, Martin Witzenrath, Cor de Wit, Ingrid Fleming, Hermann Kuppe, Wolfgang M. Kuebler
Abstract | Full text | PDF | Supplemental material (Page 4218)
Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis
Vasiliki Koliaraki, Manolis Roulis, George Kollias
Abstract | Full text | PDF | Supplemental material (Page 4231)
Adipocyte-derived endotrophin promotes malignant tumor progression
Jiyoung Park, Philipp E. Scherer
Abstract | Full text | PDF | Supplemental material (Page 4243)
Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity
Katharina Hopp, Christopher J. Ward, Cynthia J. Hommerding, Samih H. Nasr, Han-Fang Tuan, Vladimir G. Gainullin, Sandro Rossetti, Vicente E. Torres, Peter C. Harris
Abstract | Full text | PDF | Supplemental material (Page 4257)
2012 American Society for Clinical Investigation Presidential Address
Advocacy: yes we can
Advocacy: yes we can
Elizabeth M. McNally
Full text | PDF (Page 4274)
2012 Association of American Physicians Presidential Address
Next-generation academic medicine
Next-generation academic medicine
David A. Brenner
Full text | PDF (Page 4280)
2012 Association of American Physicians George M. Kober Medal
Introduction of Arthur H. Rubenstein
Introduction of Arthur H. Rubenstein
Kenneth S. Polonsky
Full text | PDF (Page 4283)
Acceptance of the 2012 Association of American Physicians George M. Kober Medal
A fortunate life in academic medicine
A fortunate life in academic medicine
Arthur H. Rubenstein
Full text | PDF (Page 4288)
2012 Association of American Physicians George M. Kober Lecture
Translating from the rivers of Babylon to the coronary bloodstream
Translating from the rivers of Babylon to the coronary bloodstream
Barry S. Coller
Full text | PDF (Page 4293)
Molecular disruption of RAD50 sensitizes human tumor cells to cisplatin-based chemotherapy
Waleed M. Abuzeid, Xiaoling Jiang, Guoli Shi, Hui Wang, David Paulson, Koji Araki, David Jungreis, James Carney, Bert W. O’Malley Jr., Daqing Li
Full text | PDF | Original article (Page 4300)
Pathogenesis of chronic obstructive pulmonary disease
Rubin M. Tuder, Irina Petrache
Full text | PDF | Original article (Page 4300)
C/EBPε mediates nicotinamide-enhanced clearance of Staphylococcus aureus in mice
Pierre Kyme, Nils H. Thoennissen, Ching Wen Tseng, Gabriela B. Thoennissen, Andrea J. Wolf, Kenichi Shimada, Utz O. Krug, Kunik Lee, Carsten Müller-Tidow, Wolfgang E. Berdel, W. David Hardy, Adrian F. Gombart, H. Phillip Koeffler, George Y. Liu
Full text | PDF | Original article (Page 4301)
Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals
Laurel Yong-Hwa Lee, Do Lien Anh Ha, Cameron Simmons, Menno D. de Jong, Nguyen Van Vinh Chau, Reto Schumacher, Yan Chun Peng, Andrew J. McMichael, Jeremy J. Farrar, Geoffrey L. Smith, Alain R.M. Townsend, Brigitte A. Askonas, Sarah Rowland-Jones, Tao Dong
Full text | PDF | Correction (Page 4301)