SAN DIEGO (EGMN) –The prevalence of dyspareunia in menopausal women ranges from 11% to 45%, according to the best estimates in the medical literature.

However, “the literature [on this topic] is terribly flawed,” Dr. Andrew T. Goldstein said at the annual meeting of the North American Menopause Society.

“Age alone is often used instead of menstrual status, there’s a failure to indicate surgical versus natural menopause, and there’s a failure to indicate if women are on hormone replacement therapy, and if so, what types. Also, the use of validated questionnaires is sorely lacking,” said Dr. Goldstein, an ob.gyn. practicing in Annapolis, Maryland, who specializes in the treatment of vulvovaginal disorders.

If anything, he continued, the prevalence of dyspareunia in menopausal women seems to be increasing because of a variety of factors, including the fact that fewer women are taking hormone therapy; 22%-45% of women not on hormone therapy have dyspareunia. In addition, “changing attitudes of postmenopausal women and their sexuality [are factors]. They expect to have sex later in life.”

Another contributing factor is the proliferation of phosphodiesterase type 5 inhibitors in recent years, which allow the partners of these women to remain sexually active, resume sexual activity, or increase sexual activity.

“Changes in the types of [hormone therapy] are also contributing, going from systemic [HT] to such things as vaginal estradiol tablets or rings which do not treat the vulva,” he said.

Dr. Goldstein cautioned clinicians not to assume that the cause of dyspareunia in menopausal women is always atrophic vaginitis. “There are many different causes of postmenopausal dyspareunia,” he said.

Many premenopausal women have dyspareunia that is never adequately treated, Dr. Goldstein added. A study by other researchers showed that 40% of women with vulvar pain never sought primary treatment (J. Am. Med. Womens Assoc. 2003;58:82-8). “In addition, at best, only 75% of women given adequate estradiol treatment are cured of their pain,” Dr. Goldstein said.

However, with a thorough history, physical, and differential diagnosis, “the specific disease process can be determined, and this will determine the correct diagnosis and treatment,” he noted.

Evaluations should include an assessment of when the dyspareunia started, the location of the pain, and the nature of the symptoms. “Different symptoms point us in different directions,” Dr. Goldstein said. “A throbbing, dull, or stabbing pain can often suggest a pelvic floor dysfunction, whereas dryness or tearing can suggest an estrogen deficiency or vulvar dermatoses. Symptoms such as hesitancy, urgency, frequency, or incomplete emptying, constipation, and rectal fissures can also suggest hypertonus pelvic floor muscles.”

He recommended that the physical exam include a careful inspection of the vulva, as at least 75% of dyspareunia cases are vulvar in origin. Special attention should be paid to the vulvar vestibule, “but we have to look at all of the structures,” he said.

The exam also should include vulvoscopy to look for areas of erythema, lichenification, fissures, erosions, ulcerations, scarring and architectural changes, evidence of atrophy, hypopigmentation and hyperpigmentation, and evidence of vulvar intraepithelial neoplasm, he said.

Another component of his exam is the “Q-tip test.” Begin by touching a moistened Q-tips swab lateral to Hart’s line, Dr. Goldstein said, and then just medial to Hart’s line. Touch the vestibule at 1 o’clock and 11 o’clock adjacent to the urethra at the ostia of the Skene’s glands. Then touch the vestibule at 4 o’clock and 8 o’clock at the ostia of the Bartholin’s gland.

“Frequently there will just be pain posteriorly and not anteriorly,” Dr. Goldstein said. “I believe that if you just have posterior pain and not anterior pain, that’s almost always a sign of hypertonus of the pelvic floor musculature, and that’s often the cause of the dyspareunia. If you have diffuse pain at the entire vestibule, that [points to] an intrinsic problem within the vestibular tissue.”

Evaluation of the pelvic floor muscles is also warranted for all women who present with dyspareunia. For this, he said, insert one finger through the hymenal ring. Press posteriorly toward the rectum, and tell the patient “this is pressure.” Then palpate the pubococcygeal, transverse perineal, and internal obturator muscles.

“For each muscle,” he said, “ask, ‘Is this pressure or pain?’ Are there trigger points? Is there hypertonicity? Can she relax the muscles?”

Next, palpate the urethra and bladder. This “should cause urgency but not burning or pain,” Dr. Goldstein said. “If there is intrinsic pain of the bladder, this may suggest interstitial cystitis/painful bladder syndrome.”

Last, palpate the pudendal nerves at the ischial spines. Are the nerves more painful than the muscles, or is one side more tender? Tender nerves can indicate pudendal neuralgia or entrapment.

Lab tests should include a wet mount, “which is absolutely essential”; cultures for speciation and sensitivity; tests for gonorrhea, chlamydia, and herpes simplex virus types 1 and 2; and serum tests of estradiol, total and free testosterone, and sex hormone–binding globulin.

“I’m a big proponent of vulvar punch biopsies,” Dr. Goldstein added. “I always send my punch biopsies with a differential diagnosis to a dermatopathologist, and I always close the biopsy with one or two interrupted Vicryl sutures.”

Atrophic vulvovaginitis is the most common cause of dyspareunia in menopausal women, he said, followed by pelvic floor dysfunction and vulvar dermatoses. Less common causes include vulvar granuloma fissuratum, desquamative inflammatory vaginitis, and interstitial cystitis.

He said he believes the addition of low-dose testosterone to estradiol helps to treat atrophy at the vulvar vestibule, but he acknowledged that this belief is based on his clinical experience and that there aren’t evidence-based studies to support this treatment.

Dr. Goldstein disclosed that he serves on the advisory boards of Boehringer Ingelheim and Wyeth. He has also received research funding from Novartis.

Copyright (c) 2009 Elsevier Global Medical News. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.

圣地亚哥（EGMN）—— 根据医学文献中的最佳估计值，绝经期妇女性交困难的患病率介于11%~45%。