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异位妊娠与紧急避孕药:一项系统评价
Ectopic Pregnancy and Emergency Contraceptive Pills: A Systematic Review
Cleland K, Raymond E, Trussell J  2010/8/19 14:02:00 
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Obstet Gynecol, 2010,
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Objective:
To evaluate the existing data to estimate the rate of ectopic pregnancy among emergency contraceptive pill treatment failures.

Data Sources:
Our initial reference list was generated from a 2008 Cochrane review of emergency contraception. In August 2009, we searched Biosys Previews, the Cochrane Database of Systematic Reviews, Medline, Global Health Database, Health Source: Popline, and Wanfang Data (a Chinese database).

Methods:
This study included data from 136 studies, which followed a defined population of women treated one time with emergency contraceptive pills (either mifepristone or levonorgestrel) and in which the number and location of pregnancies were ascertained.

Results:
Data from each article were abstracted independently by two reviewers. In the studies of mifepristone, 3 of 494 (0.6%) pregnancies were ectopic; in the levonorgestrel studies, 3 of 307 (1%) were ectopic.

Conclusion:
The rate of ectopic pregnancy when treatment with emergency contraceptive pills fails does not exceed the rate observed in the general population. Because emergency contraceptive pills are effective in lowering the risk of pregnancy, their use will reduce the chance that an act of intercourse will result in ectopic pregnancy.

Level of Evidence:
III (Table 2).

Table 2: Results by Regimen (Pregnancies of Known Location Only)
 
Regimen Population* Pregnancies Ectopic Pregnancies That Were Ectopic [% (95% CI)]
Mifepristone (all) 35,867 494 3 0.6 (0.1–1.8)
English studies 14,669 179 2 1.1 (0.1–4.0)
Chinese studies 21,197 315 1 0.3 (0.0–1.8)
Levonorgestrel (all) 15,696 307 3 1.0 (0.2–2.8)
English studies 11,405 201 2 1.0 (1.2–3.5)
Chinese studies 4,291 106 1 0.9 (0.0–5.1)
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疾病资源中心  疾病资源中心
病例分析 <span class="ModTitle_Intro_Right" id="EPMI_Home_MedicalCases_Intro_div" onclick="javascript:window.location='http://www.elseviermed.cn/tabid/127/Default.aspx'" onmouseover="javascript:document.getElementById('EPMI_Home_MedicalCases_Intro_div').style.cursor='pointer';document.getElementById('EPMI_Home_MedicalCases_Intro_div').style.textDecoration='underline';" onmouseout="javascript:document.getElementById('EPMI_Home_MedicalCases_Intro_div').style.textDecoration='none';">[栏目介绍]</span>  病例分析 [栏目介绍]

 王燕燕 王曙

上海交通大学附属瑞金医院内分泌科

患者,女,69岁。2009年1月无明显诱因下出现乏力,当时程度较轻,未予以重视。2009年3月患者乏力症状加重,尿色逐渐加深,大便习惯改变,颜色变淡。4月18日入我院感染科治疗,诉轻度头晕、心慌,体重减轻10kg。无肝区疼痛,无发热,无腹痛、腹泻、腹胀、里急后重,无恶性、呕吐等。入院半月前于外院就诊,查肝功能:ALT 601IU/L,AST 785IU/L,TBIL 97.7umol/L,白蛋白 41g/L,甲状腺功能:游离T3 30.6pmol/L,游离T4 51.9pmol/L,心电图示快速房颤。
 

医学数据库  医学数据库



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