全球精选文摘 - 原发性甲状旁腺功能亢进患儿的最佳治疗方案是什么？

高级搜索

免费注册

首页

期刊文献

全球精选文摘

中国作者重要发表

爱思唯尔期刊精选全文

柳叶刀中文版精选全文

2009年诺贝尔奖得主文章

成功投稿经验系列访谈

2010年度诺贝尔奖得主

医药资讯

医学资讯

药品动态

诊疗指南

病例分析

数据库

会议精粹

柳叶刀流感峰会

2009世界高血压大会

辉瑞中国医学研究高峰论坛

上海东方呼吸病国际论坛

GAP-CCBC系列会议

精品书籍

爱思唯尔参考书

新书订购活动

疾病资源

专家博客

当前位置 > > > >

原发性甲状旁腺功能亢进患儿的最佳治疗方案是什么？

What is the optimal treatment for children with primary hyperparathyroidism?

Durkin, ET, Nichol, PF, Lund, DP 2010/10/22 15:16:40

【发表评论】【全球专家评论】

打印| 推荐给好友

J Pediatr Surg , 2010,

专家评级：

★

循证评级：

View at Publisher

Purpose:
Little information exists regarding the optimal surgical treatment of pediatric primary hyperparathyroidism. We hypothesized that primary hyperparathyroidism in children, in the absence of a family history, is caused by single-gland disease and is amenable to minimally invasive parathyroidectomy (MIP).

Methods:
We reviewed the records of individuals younger than 25years who underwent parathyroidectomy in a prospectively collected database at a single tertiary hospital from 2003 to 2009.

Results:
Twenty-five patients were identified, with a mean (SD) age of 19 (3.7)years. Sixty percent had single-gland disease (n=15). Familial disease was present in 6 patients. All of the children younger than 18years without a family history of disease (9/9) were found to have a single-gland disease (P<.001). Seventy-eight percent of patients without a family history were successfully treated without a bilateral exploration. Average length of stay was less than 1day with no complications or recurrences.

Conclusions:
Primary hyperparathyroidism in patients younger than 18years without a family history was uniformly caused by single-gland disease. Minimally invasive parathyroidectomy was successful in these patients and avoided the morbidity of bilateral exploration. We recommend MIP be used in pediatric patients at large referral centers with prior successful institutional experience with the technique (Fig 2).

请登录后发表评论，点击此处登录。

全部学科

疾病资源中心

高血压	慢性阻塞性肺病
脂肪性肝病	糖尿病
卒中	肺癌
冠心病	子宫内膜异位症
结直肠癌	乳腺癌
心力衰竭	心律失常

病例分析 [栏目介绍]

甲状腺功能亢进合并黄疸

王燕燕王曙

上海交通大学附属瑞金医院内分泌科

患者，女，69岁。2009年1月无明显诱因下出现乏力，当时程度较轻，未予以重视。2009年3月患者乏力症状加重，尿色逐渐加深，大便习惯改变，颜色变淡。4月18日入我院感染科治疗，诉轻度头晕、心慌，体重减轻10kg。无肝区疼痛，无发热，无腹痛、腹泻、腹胀、里急后重，无恶性、呕吐等。入院半月前于外院就诊，查肝功能：ALT 601IU/L，AST 785IU/L，TBIL 97.7umol/L，白蛋白 41g/L，甲状腺功能：游离T3 30.6pmol/L，游离T4 51.9pmol/L，心电图示快速房颤。

更多>>>

医学数据库