全球精选文摘 - 短期激素替代治疗对长期骨密度的影响

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短期激素替代治疗对长期骨密度的影响

The effects of short-term hormone replacement therapy on long-term bone mineral density

Middleton ET, Steel SA 2009/5/27 10:50:39

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Climacteric, 2007,

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Abstract

Introduction:

Short-term hormone replacement therapy (HRT) relieves menopausal symptoms and increases bone mineral density (BMD), but bone loss reoccurs upon discontinuation. This study assesses whether short-term HRT provides long-term BMD benefits.

Method:

This was a prospective study of women aged 50-54 years followed up for 9 years. Women were categorized into three groups according to the treatment they received: No-HRT (n=340), Short-term HRT (2-4 years, n=60), and Long-term HRT (9 years, n=187).

Results:

BMD increased significantly at the hip (2.4%, p<0.001) and spine (8.0%, p<0.001) over 9 years in the Long-term HRT group. Women without treatment lost BMD at the hip (−4.2%, p<0.001) and spine (−3.5%, p<0.001). Women in the Short-term HRT group had no significant loss of BMD at the hip (−1.6%, p=0.08) or spine (−1.4%, p=0.18) over 9 years. BMD in the Short-term HRT group was significantly higher at 9 years than in the No-HRT group at both spine (difference 0.023g/cm(2), p=0.048) and hip (difference 0.016g/cm(2), p=0.042).

Conclusion:

After 9 years, women who had taken short-term HRT had no significant loss of BMD and were better off in terms of BMD than those left untreated. Short-term HRT in the early postmenopausal period provides long-term BMD benefits

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疾病资源中心

高血压	慢性阻塞性肺病
脂肪性肝病	糖尿病
卒中	肺癌
冠心病	子宫内膜异位症
结直肠癌	乳腺癌
心力衰竭	心律失常

病例分析 [栏目介绍]

甲状腺功能亢进合并黄疸

王燕燕王曙

上海交通大学附属瑞金医院内分泌科

患者，女，69岁。2009年1月无明显诱因下出现乏力，当时程度较轻，未予以重视。2009年3月患者乏力症状加重，尿色逐渐加深，大便习惯改变，颜色变淡。4月18日入我院感染科治疗，诉轻度头晕、心慌，体重减轻10kg。无肝区疼痛，无发热，无腹痛、腹泻、腹胀、里急后重，无恶性、呕吐等。入院半月前于外院就诊，查肝功能：ALT 601IU/L，AST 785IU/L，TBIL 97.7umol/L，白蛋白 41g/L，甲状腺功能：游离T3 30.6pmol/L，游离T4 51.9pmol/L，心电图示快速房颤。

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