全球精选文摘 - 孕期母体消耗含二十二碳六烯酸的功能性食物：对婴儿9个月时提高解决问题的能力有益但对认知和记忆无明显益处

Maternal consumption of a docosahexaenoic acid–containing functional food during pregnancy: benefit for infant performance on problem-solving but not on recognition memory tasks at age 9mo

Judge MP, Harel O, Lammi-Keefe CJ 2009/5/27 10:50:40

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Am J Clin Nutr, 2007,

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Abstract
Background:
There are few studies reporting on docosahexaenoic acid (DHA, 22:6n–3) supplementation during pregnancy and infant cognitive function. DHA supplementation in pregnancy and infant problem solving in the first year have not been investigated.

Objective:
We tested the hypothesis that infants born to women who consumed a DHA-containing functional food during pregnancy would demonstrate better problem-solving abilities and recognition memory than would infants born to women who consumed the placebo during pregnancy.

Design:
In a double-blind, placebo-controlled, randomized trial, pregnant women consumed a DHA-containing functional food or a placebo from gestation week 24 until delivery. Study groups received DHA-containing cereal-based bars (300mg DHA/92-kcal bar; average consumption: 5bars/wk; n=14) or cereal-based placebo bars (n=15). The Infant Planning Test and Fagan Test of Infant Intelligence were administered to infants at age 9mo. The problem-solving trial included a support step and a search step. The procedure was scored on the basis of the infant's performance on each step and on the entire problem (intention score and total intentional solutions). Scores were generated on the basis of the cumulative performance of the infant on 5 trials.

Results:
Treatment had significant effects on the performance of problem-solving tasks: total intention score (P=0.017), total intentional solutions (P=0.011), and number of intentional solutions on both cloth (P=0.008) and cover (P=0.004) steps. There were no significant differences between groups in any measure of Fagan Test of Infant Intelligence.

Conclusion:
These data point to a benefit for problem solving but not for recognition memory at age 9mo in infants of mothers who consumed a DHA-containing functional food during pregnancy.

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疾病资源中心

高血压	慢性阻塞性肺病
脂肪性肝病	糖尿病
卒中	肺癌
冠心病	子宫内膜异位症
结直肠癌	乳腺癌
心力衰竭	心律失常

病例分析 [栏目介绍]

甲状腺功能亢进合并黄疸

王燕燕王曙

上海交通大学附属瑞金医院内分泌科

患者，女，69岁。2009年1月无明显诱因下出现乏力，当时程度较轻，未予以重视。2009年3月患者乏力症状加重，尿色逐渐加深，大便习惯改变，颜色变淡。4月18日入我院感染科治疗，诉轻度头晕、心慌，体重减轻10kg。无肝区疼痛，无发热，无腹痛、腹泻、腹胀、里急后重，无恶性、呕吐等。入院半月前于外院就诊，查肝功能：ALT 601IU/L，AST 785IU/L，TBIL 97.7umol/L，白蛋白 41g/L，甲状腺功能：游离T3 30.6pmol/L，游离T4 51.9pmol/L，心电图示快速房颤。

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