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子宫内膜异位症患者腹腔液体中瘦素与慢性盆腔痛相关，但与不育无相关性

Peritoneal fluid leptin is associated with chronic pelvic pain but not infertility in endometriosis patients

Bedaiwy MA, Falcone T, Goldberg JM 2009/5/27 10:50:40

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Hum Reprod, 2006,

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Abstract

Background:

Leptin influences the proinflammatory immune responses and has angiogenic activity in vitro and in vivo. The objective of this study was to evaluate the peritoneal fluid levels of leptin in patients with endometriosis and idiopathic infertility and compare them with a control group of tubal ligation/reanastomosis patients.

Methods:

In this observational, prospective controlled study, peritoneal fluid from 108 women was obtained while they underwent laparoscopy for pelvic pain, infertility, tubal ligation or sterilization reversal. We measured the concentration of leptin in the peritoneal fluid and compared the levels among women who were divided into groups according to their postsurgical diagnosis. Sixty patients were diagnosed with endometriosis, 10 with idiopathic infertility and 38 had undergone tubal ligation or reanastomosis (control group).

Results:

Peritoneal fluid leptin was significantly higher in endometriosis 14.62± 9.79 (mean± SD) ng/ml compared to idiopathic infertility [0.92± 1.57 ng/ml (P = 0.0007)] and to controls [0.78± 1.94 ng/ml (P< 0.0001)]. Leptin levels were positively correlated with the stage of endometriosis (r = 0.45; P = 0.03), and with pelvic pain in endometriosis patients (r = 0.49; P = 0.001). Peritoneal fluid leptin levels in patients with idiopathic infertility were comparable to controls.

Conclusions:

Higher levels of leptin were observed in peritoneal fluid of patients with endometriosis compared to those without the disease. These data suggest that the proinflammatory and neoangiogenic action of leptin may contribute to the pathogenesis of endometriosis. Moreover, leptin may play a role in endometriosis-associated pain

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疾病资源中心

高血压	慢性阻塞性肺病
脂肪性肝病	糖尿病
卒中	肺癌
冠心病	子宫内膜异位症
结直肠癌	乳腺癌
心力衰竭	心律失常

病例分析 [栏目介绍]

甲状腺功能亢进合并黄疸

王燕燕王曙

上海交通大学附属瑞金医院内分泌科

患者，女，69岁。2009年1月无明显诱因下出现乏力，当时程度较轻，未予以重视。2009年3月患者乏力症状加重，尿色逐渐加深，大便习惯改变，颜色变淡。4月18日入我院感染科治疗，诉轻度头晕、心慌，体重减轻10kg。无肝区疼痛，无发热，无腹痛、腹泻、腹胀、里急后重，无恶性、呕吐等。入院半月前于外院就诊，查肝功能：ALT 601IU/L，AST 785IU/L，TBIL 97.7umol/L，白蛋白 41g/L，甲状腺功能：游离T3 30.6pmol/L，游离T4 51.9pmol/L，心电图示快速房颤。

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