全球精选文摘 - 美国单纯疱疹病毒1型和2型血清阳性率趋势

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美国单纯疱疹病毒1型和2型血清阳性率趋势

Trends in Herpes Simplex Virus Type 1 and Type 2 Seroprevalence in the United States

Xu F, Sternberg MR, Kottiri BJ 2009/5/27 10:50:40

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JAMA, 2006,

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Abstract

Context:

Herpes simplex virus type 1 (HSV-1) and type 2 are common infections worldwide. Herpes simplex virus type 2 (HSV-2) is the cause of most genital herpes and is almost always sexually transmitted. In contrast, HSV-1 is usually transmitted during childhood via nonsexual contacts. Preexisting HSV-1 antibodies can alleviate clinical manifestations of subsequently acquired HSV-2. Furthermore, HSV-1 has become an important cause of genital herpes in some developed countries.

Objective:

To examine trends in HSV-1 and HSV-2 seroprevalence in the United States in 1999–2004 compared with 1988–1994.

Design, Settings, and Participants:

Cross-sectional, nationally representative surveys (US National Health and Nutrition Examination Surveys [NHANES]), were used to compare national seroprevalence estimates from 1999–2004 with those from 1988–1994, and changes in HSV-1 and HSV-2 seroprevalence since 1976–1980 were reviewed. Persons aged 14 to 49 years were included in these analyses.

Main Outcome Measures:

Seroprevalence of HSV-1 and HSV-2 antibodies based on results from type-specific immunodot assays; diagnosis of genital herpes.

Results:

The overall age-adjusted HSV-2 seroprevalence was 17.0% (95% confidence interval [CI], 15.8%-18.3%) in 1999–2004 and 21.0% (95% CI, 19.1%–23.1%) in 1988–1994, a relative decrease of 19.0% between the 2 surveys (95% CI, −28.6% to −9.5%; P<.001). Decreases in HSV-2 seroprevalence were especially concentrated in persons aged

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疾病资源中心

高血压	慢性阻塞性肺病
脂肪性肝病	糖尿病
卒中	肺癌
冠心病	子宫内膜异位症
结直肠癌	乳腺癌
心力衰竭	心律失常

病例分析 [栏目介绍]

甲状腺功能亢进合并黄疸

王燕燕王曙

上海交通大学附属瑞金医院内分泌科

患者，女，69岁。2009年1月无明显诱因下出现乏力，当时程度较轻，未予以重视。2009年3月患者乏力症状加重，尿色逐渐加深，大便习惯改变，颜色变淡。4月18日入我院感染科治疗，诉轻度头晕、心慌，体重减轻10kg。无肝区疼痛，无发热，无腹痛、腹泻、腹胀、里急后重，无恶性、呕吐等。入院半月前于外院就诊，查肝功能：ALT 601IU/L，AST 785IU/L，TBIL 97.7umol/L，白蛋白 41g/L，甲状腺功能：游离T3 30.6pmol/L，游离T4 51.9pmol/L，心电图示快速房颤。

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