中国作者重要发表 - 中国人群出生时低体重和成年时超重相互作用是代谢综合征的发病原因



中国人群出生时低体重和成年时超重相互作用是代谢综合征的发病原因





Developmental origin of metabolic syndrome: Interaction of thinness at birth and overweight during adult life in Chinese population





Mi J., Cheng H., Zhao X.-Y., Hou D.-Q., Chen F.-F., Zhang K.-L. 2009/5/29 18:38:57

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Obesity Reviews, 2008, Volume 9, Issue 1




In the present study we explore the association between the ponderal index (PI) at birth and the metabolic syndrome (MetS) in middle-aged population in China. A total of 975 men and women aged 41-52 years with detailed birth records were followed up and recruited for clinic examinations, involving anthropometry and measurements of blood pressure, fasting plasma glucose, serum lipid profile. The MetS was diagnosed according to the National Cholesterol Education Program (Adult Treatment Panel III) definition. Multivariate logistic regression analysis estimated the effect of PI on MetS and the interaction between PI at birth and adult body mass index (BMI). The average prevalence of MetS was 19.3%, with rates of 23.7%, 22.9%, 16.9% and 16.5% in those who at birth were <25th percentile, the 25th-50th percentile, the 50th-75th percentile and >75th percentile PI respectively, with a significant decreasing trend (x 2for trend = 5.661, P = 0.017). Logistic regression analysis showed that 25.7% of the occurrence of MetS was attributable to PI at birth and adult BMI both acting independently and synergistically. In summary thinness at birth predicts the later occurrence of MetS, as well as modifying the association between later BMI and MetS. Overweight later in life was most deleterious for those with growth retardation at birth. © 2007 The Authors.



Correspondence Address: Mi, J.; Department of Epidemiology, Capital Institute of Pediatrics, 2 Ya Bao Lu, Beijing 100020, China; email: jiemi@vip.163.com



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高血压	慢性阻塞性肺病
脂肪性肝病	糖尿病
卒中	肺癌
冠心病	子宫内膜异位症
结直肠癌	乳腺癌
心力衰竭	心律失常

病例分析

甲状腺功能亢进合并黄疸

王燕燕王曙

上海交通大学附属瑞金医院内分泌科

患者，女，69岁。2009年1月无明显诱因下出现乏力，当时程度较轻，未予以重视。2009年3月患者乏力症状加重，尿色逐渐加深，大便习惯改变，颜色变淡。4月18日入我院感染科治疗，诉轻度头晕、心慌，体重减轻10kg。无肝区疼痛，无发热，无腹痛、腹泻、腹胀、里急后重，无恶性、呕吐等。入院半月前于外院就诊，查肝功能：ALT 601IU/L，AST 785IU/L，TBIL 97.7umol/L，白蛋白 41g/L，甲状腺功能：游离T3 30.6pmol/L，游离T4 51.9pmol/L，心电图示快速房颤。

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