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| 15-脂氧化酶-1诱导培养的人类肺上皮细胞中的趋化因子表达及释放 |
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| 15-Lipoxygenase-1 induces expression and release of chemokines in cultured human lung epithelial cells |
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| Liu, C., Xu, D., Liu, L., Schain, F., Brunnström, Å., Björkholm, M., Claesson, H.-E., Sjöberg, J. 2009/7/29 13:33:00 |
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American Journal of Physiology - Lung Cellular and Molecular Physiology, 2009, Volume 297, Issue 1
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15-Lipoxygenase-1 (15-LOX-1) has been proposed to be involved in various physiological and pathophysiological activities such as inflammation, atherosclerosis, cell maturation, and tumorigenesis. Asthma and chronic obstructive pulmonary disease are associated with increased expression of 15-LOX-1 in bronchial epithelial cells, but the potential functions of 15-LOX-1 in airway epithelial cells have not been well clarified. To study the function of 15-LOX-1 in bronchial epithelial cells, we ectopically expressed 15-LOX-1 in the human lung epithelial cell line A549.
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| Correspondence Address: Liu, C.; Hematology Laboratory, Center for Molecular Medicine, L8:00, Karolinska Univ. Hospital Solna, SE-171 76 Stockholm, Sweden; email:Cheng.liu@ki.se |
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 疾病资源中心
王燕燕 王曙
上海交通大学附属瑞金医院内分泌科
患者，女，69岁。2009年1月无明显诱因下出现乏力，当时程度较轻，未予以重视。2009年3月患者乏力症状加重，尿色逐渐加深，大便习惯改变，颜色变淡。4月18日入我院感染科治疗，诉轻度头晕、心慌，体重减轻10kg。无肝区疼痛，无发热，无腹痛、腹泻、腹胀、里急后重，无恶性、呕吐等。入院半月前于外院就诊，查肝功能：ALT 601IU/L，AST 785IU/L，TBIL 97.7umol/L，白蛋白 41g/L，甲状腺功能：游离T3 30.6pmol/L，游离T4 51.9pmol/L，心电图示快速房颤。
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