中国作者重要发表 - 2型糖尿病妇女咖啡摄入量与心血管事件风险和全因死亡率的关系



2型糖尿病妇女咖啡摄入量与心血管事件风险和全因死亡率的关系





Coffee consumption and risk of cardiovascular events and all-cause mortality among women with type 2 diabetes





Zhang W.L., Lopez-Garcia E., Li T.Y., Hu F.B., van Dam R.M. 2009/5/29 18:38:56

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Diabetologia, 2009, Volume 0,




Aims/hypothesis: Coffee has been linked to both beneficial and harmful health effects, but data on its relationship with cardiovascular disease and mortality in patients with type 2 diabetes are sparse. Methods: This was a prospective cohort study including 7,170 women with diagnosed type 2 diabetes but free of cardiovascular disease or cancer at baseline. Coffee consumption was assessed in 1980 and then every 2-4 years using validated questionnaires. A total of 658 incident cardiovascular events (434 coronary heart disease and 224 stroke) and 734 deaths from all causes were documented between 1980 and 2004. Results: After adjustment for age, smoking and other cardiovascular risk factors, the relative risks were 0.76 (95% CI 0.50-1.14) for cardiovascular diseases (p trend∈=∈0.09) and 0.80 (95% CI 0.55-1.14) for all-cause mortality (p trend∈=∈0.05) for the consumption of ≥4 cups/day of caffeinated coffee compared with non-drinkers. Similarly, multivariable RRs were 0.96 (95% CI 0.66-1.38) for cardiovascular diseases (p trend∈=∈0.84) and 0.76 (95% CI 0.54-1.07) for all-cause mortality (p trend∈=∈0.08) for the consumption of ≥2 cups/day of decaffeinated coffee compared with non-drinkers. Higher decaffeinated coffee consumption was associated with lower concentrations of HbA1c (6.2% for ≥2 cups/day versus 6.7% for <1 cup/month; p trend∈=∈0.02). Conclusions: These data provide evidence that habitual coffee consumption is not associated with increased risk of cardiovascular diseases or premature mortality among diabetic women. © 2009 Springer-Verlag.



Correspondence Address: Zhang, W. L.; Sino-German Laboratory for Molecular Medicine, FuWai Cardiovascular Hospital, Chinese Academy of Medical Sciences, Beijing 100037, China; email: weilizhang@sglab.org



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高血压	慢性阻塞性肺病
脂肪性肝病	糖尿病
卒中	肺癌
冠心病	子宫内膜异位症
结直肠癌	乳腺癌
心力衰竭	心律失常

病例分析

甲状腺功能亢进合并黄疸

王燕燕王曙

上海交通大学附属瑞金医院内分泌科

患者，女，69岁。2009年1月无明显诱因下出现乏力，当时程度较轻，未予以重视。2009年3月患者乏力症状加重，尿色逐渐加深，大便习惯改变，颜色变淡。4月18日入我院感染科治疗，诉轻度头晕、心慌，体重减轻10kg。无肝区疼痛，无发热，无腹痛、腹泻、腹胀、里急后重，无恶性、呕吐等。入院半月前于外院就诊，查肝功能：ALT 601IU/L，AST 785IU/L，TBIL 97.7umol/L，白蛋白 41g/L，甲状腺功能：游离T3 30.6pmol/L，游离T4 51.9pmol/L，心电图示快速房颤。

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