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中国人群中血压异常引起的过早死亡:一项前瞻性队列研究 |
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Premature deaths attributable to blood pressure in China: a prospective cohort study |
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He J, Gu D, Chen J, Wu X, Kelly TN, Huang J-f, Chen J-c, Chen C-S, Bazzano LA, Reynolds K, Whelton PK, Klag MJ 2009/12/15 14:48:00 |
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The Lancet, 2009, Volume 374, Issue 9703
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Background: Hypertension is a major global-health challenge because of its high prevalence and concomitant risks of cardiovascular disease. We estimated premature deaths attributable to increased blood pressure in China. Methods: We did a prospective cohort study in a nationally representative sample of 169 871 Chinese adults aged 40 years and older. Blood pressure and other risk factors were measured at a baseline examination in 1991 and follow-up assessment was done in 1999-2000. Premature death was defined as mortality before age 72 years in men and 75 years in women, which were the average life expectancies in China in 2005. We calculated the numbers of total and premature deaths attributable to blood pressure using population-attributable risk, mortality, and the population size of China in 2005. Findings: Hypertension and prehypertension were significantly associated with increased all-cause and cardiovascular mortality (p<0·0001). We estimated that in 2005, 2·33 million (95% CI 2·21-2·45) cardiovascular deaths were attributable to increased blood pressure in China: 2·11 million (2·03-2·20) in adults with hypertension and 0·22 million (0·19-0·25) in adults with prehypertension. Additionally, 1·27 million (1·18-1·36) premature cardiovascular deaths were attributable to raised blood pressure in China: 1·15 million (1·08-1·22) in adults with hypertension and 0·12 million (0·10-0·14) in adults with prehypertension. Most blood pressure-related deaths were caused by cerebrovascular diseases: 1·86 million (1·76-1·96) total deaths and 1·08 million (1·00-1·15) premature deaths. Interpretation: Increased blood pressure is the leading preventable risk factor for premature mortality in the Chinese general population. Prevention and control of this condition should receive top public-health priority in China. Funding: American Heart Association (USA); National Heart, Lung, and Blood Institute, National Institutes of Health (USA); Ministry of Health (China); and Ministry of Science and Technology (China). © 2009 Elsevier Ltd. All rights reserved.
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Correspondence Address: He, J.; Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, United States; email:jhe@tulane.edu |
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疾病资源中心
王燕燕 王曙
上海交通大学附属瑞金医院内分泌科
患者,女,69岁。2009年1月无明显诱因下出现乏力,当时程度较轻,未予以重视。2009年3月患者乏力症状加重,尿色逐渐加深,大便习惯改变,颜色变淡。4月18日入我院感染科治疗,诉轻度头晕、心慌,体重减轻10kg。无肝区疼痛,无发热,无腹痛、腹泻、腹胀、里急后重,无恶性、呕吐等。入院半月前于外院就诊,查肝功能:ALT 601IU/L,AST 785IU/L,TBIL 97.7umol/L,白蛋白 41g/L,甲状腺功能:游离T3 30.6pmol/L,游离T4 51.9pmol/L,心电图示快速房颤。
医学数据库
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