高级搜索
立即登录 | 免费注册
当前位置 >   首页 > 期刊文献 > 中国作者重要发表 > 文摘导读
茶消耗量与子宫内膜癌风险：一项荟萃分析
Tea consumption and risk of endometrial cancer: a metaanalysis
Tang N-P, Li H, Qiu Y-L, Zhou G-M, Ma J  2009/12/22 13:38:00 
【发表评论】
打印| 推荐给好友
American Journal of Obstetrics and Gynecology, 2009, Volume 201, Issue 6 
 

Objective: The objective of the study was to assess the association between tea consumption and endometrial cancer. Study Design: Studies were identified by searching PubMed and EMBASE databases and screening the references of retrieved articles. The summary relative risk (RR) with 95% confidence interval (CI) was calculated. Results: The combined RR for ever drinkers vs non/lowest drinkers was 0.85 (95% CI, 0.77-0.94). Compared with non/lowest drinkers, the summary RR was 0.88 (95% CI, 0.78-0.98) for low to moderate drinkers and 0.75 (95% CI, 0.64-0.88) for high drinkers. An increase in tea intake of 2 cups/day was associated with a 25% decreased risk of endometrial cancer. In subgroup analyses, tea consumption was significantly associated with reduced endometrial cancer risk in Asian studies and studies using interviewing techniques. Furthermore, the protective effect of green tea on endometrial cancer seemed more evident than that of black tea. Conclusion: Findings from this metaanalysis suggest that tea consumption may reduce the risk of endometrial cancer. Because of the limited number of studies, further prospective studies are needed to explore the protective effect of tea on endometrial cancer. © 2009 Mosby, Inc. All rights reserved.
Correspondence Address: Tang, N.-P.; National Shanghai Center for New Drug Safety Evaluation and Research, Shanghai Institute of Pharmaceutical Industry, Pudong, Shanghai, China; email:naping.tang@gmail.com 
  评论
 
Zhou Ankai 说： 2009-12-30
Objective: The objective of the
【回复】
小生 说： 2009-12-25
Is tea really helpful?

Chen Huai Sheng from ICU of Shenzhen People's Hospital

Tea is a drink with a long history. In some countries, such as China and Japan, tea is always popular and has become a part of culture. There are teas of all kind, according to the methods of fermentation. Green tea is a kind of products without being fermented. Biluochun and Longjing teas are representatives of green tea. Black teas are fully fermented before being production. Qing Cha is half-fermented, and is in the range of between green tea and black tea. Representative of Qing Cha is Tieguanyin tea. As both 'Qing' and 'Lu' mean green in China, people sometimes are confused by the green tea and Qing Cha.

There were many evidences suggesting the cancer preventing and curing functions of green tea[1], or other types of tea. As we have suggested, all clinical evidences must have its pharmacological and pathophysiological mechanisms, green tea would not be an exception. epigallocatechin(EGC), epicatechin-gallate(ECG) and EGC3-gallate(EGCG) are contented in green tea. These catechins were acted as antioxidants and free-radical scavenging. They also inducted or modified metabolic enzymes selectively[2]. Recent studies suggested that the different kinds of catechins have different growth suppressive effects[3]. Green tea could inhibit biochemical markers of tumor initiation and promotion, prevent the cell replication so as to inhibit the growth and development of neoplasms. However, if catechins can explain the cancer curing and preventing effects of green tea, other kinds of tea would also help. Almost all teas included similar catechins[4]. Besides, if tea polyphenols can help in preventing and curing cancer, high concentration of polyphenols were also contented in Qing Cha too[4]. Some researches, also did not published informal journals, suggested Puerh tea have highest concentration of polyphenols among all kinds of teas. So, if there are any other mechanisms for green tea to prevent and cure cancer? Or other teas have similar effects?

Tea is now world wide popular. But Chinese and Japanese had integrated tea into culture respectively. People in Chao Shan area, which located in the western Guangdong and is closed to seaside, are especially like drinking tea. The only difference is that, there is a higher incidence of oesophageal malignant cancer in Jie Yang City than in other Chao Shan cities. The incidence of oesophageal cancer is only less than that of Lin County in Henan province. The mortality of oesophageal cancer is about 66.6/100,000/year[5]. In some county, the mortality is as high as 100/100,000/year. Many high risk factor *** plained the high incidence of esophageal malignant cancer. Drunk[6],smoking[7], over-hot tea drinking habit, fasting eating, animal oil, meat consumption[8], fish juice and pickles[9] are important risk factors. Geographical factor also plays an important role. Geography affects the eating habits of Chao Shan region[10], so as to induce different incidence of esophageal malignancy[11]. Furthermore, soil and vegetation types between high- and low-risk areas of esophageal cancer in Guangdong were different. The soil organic carbon densities(SOCD) correlated negatively with esophageal cancer mortality[12]. Finally, gene abnormality should be a critical factor for cancer[13]. Anyway, the appearance and promotion of cancer are complicated, and induced by multi-factors. If tea can prevent and cure the cancer, it must have capability to prevent and reverse all these risk factors.

Congou tea, a kind of ancient tea ceremony, has been enthroned by people in Chao Shan region for several hundred years. People used to blew up congou tea with Qing Cha as its scents and beautiful colour as well[14]. Green tea accounts a few part of the market in this region. But whatever tea they used, congou tea seemed to be a protecting factor, even for mild to middle smoking persons[15]. On the other hand, water drinking is also a kind of protecting factor[8].

A previous systematic review included epidemiological studies and randomized trials[1].Although the qualities were good or moderate, the authors of original studies didn?t described what kind of green tea they used, the concentration, and the precise quantity of tea. As the quality, the place of production, and the collecting season of tea also affect the pharmacological effects, they should be foci on the studies. The similar condition appeared again in the later meta-analysistoo[16]. After all, there were some questions rising after reading the systematic reviews. Firstly, if green tea is really help? (May be the systematic review has given positive answer.) Or other teas and water drinking have similar functions? Secondly, if green tea is better than other teas in preventing and curing cancers, what is the mechanism? There should be mechanism other than catechins, or polyphenols. Or if green tea is no more effective than other teas in this field, why Jie Yang City have higher incidence of oesophageal carcinoma than other Chao Shan Cities as tea is popular in all Chao Shan region?

Finally, how many quantity of tea is suitable for preventing and curing cancers? And what kind of concentration would be better? And the most important is that, if we promote green tea in this region, where the tea culture has become so popular, can we reduce the incidence of malignant carcinoma in the future? A well-designed long-term research in this region seems to be necessary, which can to some certain answer these questions.

References:
1,Jianping Liu,Jianmin Xing,Yutong Fei. Green tea(Camelliasinensis) and cancer prevention: a systematic review of randomized trials and epidemiological studies. Chinese Medicine 2008,3:12doi:10.1186/1749-8546-3-12.
2,Brown MD. Greentea(Camelliasinensis) extract and its possible role in the prevention of cancer. AlternMedRev.1999Oct;4(5):360-70.
3,Ravindranath MH,Ramasamy V,Moon S,Ruiz C,Muthugounder S. Differential Growth Suppression of Human Melanoma Cellsby Tea(Camelliasinensis) Epicatechins(ECG,EGCand EGCG). Evid Based Complement AlternatMed.2008Jan3.eCAM,doi:10.1093/ecam/nem140.
4,Peng Shao Ping, Gu Zhen Lun. Comparations of polyphenols between commercializing teas. Fu Jian Cha Ye,2005;2:32-33.
5,Chen Wei San,Cai Shu Shen,Qiu Jie Wen,Zhu Li Huang,Lin Kun,Chen Hong Ying, et al. Epidemological study of esophageal carcinoma in Jie Yang City, Guang dong. The Cancer,1994;13(2):159-163.
6,Li Ke, Yu Ping, Zhu Yuan Feng, Zhang Zhi Xin, Huang Shao Shan, Huang Ge, et al. Study of risk factors for esophageal carcinoma in high incidental area of Chaoshan region of China. Chinese Cancer,2001;10(11):633-636.
7,Li Ke, Yu Ping, Zhu Yuan Feng, Zhang Zhi Xin, Huang Shao Shan, Huang Ge, et al. Study of risk factor of smoking in esophageal cancer high incidence area at South China coast.Tumor,2002;22(2):96-99.
8,Zhang Wen Ding, An Feng Shan, Lin Han Sheng, Yu Hua Fei, Chen Shao Hu, Wang Sheng Yong. A case-control study on the risk factors of esophageal cancer in jieyang city of Guangdong in China. Chin J Epidemiol,2001;22(6):442-446.
9,Li Ke, Yu Ping, Zhang Zhi Xin, Huang Shao Shan, Huang Ge, et al. Food components and risk of esophageal cancer in Chaoshan region of China, a high-risk area of esophageal cancer. Chinese Journal of Cancer,2001;20(2):160-163.
10,Su Ying Chun, Chen Zhong Nuan. On the influence of geographical environment on the diet culture of Chaoshan. Yun Nan Geographic Environment Research. 2004;16(4):61-65.
11,Lv Lai Wen, Li Ke. A Comparative Dietary Survey for Inhabitants in Chaoshan Area, China with High and Low Esophageal Cancer Incidence.CNKI:CDMD:2.2006.173092.
12,Wu Ku Sheng, Li Ke. Comparison of Soil and Vegetation Characteristics between High-and Low-Risk Areas of Esophageal Cancer in Guangdong, China Based on Geographic Information System(GIS).ChineseCancer,2007;16(9):683-685.
13,Shi Jian, Zhong Xue Yun, Chen Shao Hu.p16 gene expression and deletion in the esophageal carcinoma a of Jieyang City. Prevention and treatment researches of cancer, 2002;29(3):212-214.
14,Li Zhen Tong, Wen Wei Min. Talk about Chao Shan congou tea. Chinese Food, 1998;8:42-43.
15,Li Ke, Yu Ping, Zhu Yuan Feng, Zhang Zhi Xin, Huang Shao Shan, Huang Ge, et al. Relationship between congou tea and esophageal cancer in Chaoshan region of Guangdong, China. Chin JD is Control Prev,2002:6(1):47-49.
16,Tang NP, Li H, Qiu YL, Zhou GM, Ma J. Tea consumption and risk of endometrial cancer: a meta analysis. American Journal of Obstetrics and Gynecology, 2009;201(6):605.e1-8.
【回复】

请登录后发表评论，点击此处登录。

疾病资源中心  疾病资源中心
 病例分析
甲状腺功能亢进合并黄疸

 王燕燕 王曙

上海交通大学附属瑞金医院内分泌科

患者，女，69岁。2009年1月无明显诱因下出现乏力，当时程度较轻，未予以重视。2009年3月患者乏力症状加重，尿色逐渐加深，大便习惯改变，颜色变淡。4月18日入我院感染科治疗，诉轻度头晕、心慌，体重减轻10kg。无肝区疼痛，无发热，无腹痛、腹泻、腹胀、里急后重，无恶性、呕吐等。入院半月前于外院就诊，查肝功能：ALT 601IU/L，AST 785IU/L，TBIL 97.7umol/L，白蛋白 41g/L，甲状腺功能：游离T3 30.6pmol/L，游离T4 51.9pmol/L，心电图示快速房颤。
 

医学数据库  医学数据库



友情链接：中文版柳叶刀 | MD CONSULT | Journals CONSULT | Procedures CONSULT | eClips CONSULT | Imaging CONSULT | 论文吧 | 世界医学书库 | 医心网 | 前沿医学资讯网

公司简介 | 用户协议 | 条件与条款 | 隐私权政策 | 网站地图 | 联系我们

 互联网药品信息服务资格证书 | 卫生局审核意见通知书 | 药监局行政许可决定书 
电信与信息服务业务经营许可证 | 京ICP证070259号 | 京ICP备09068478号

Copyright © 2009 Elsevier.  All Rights Reserved.  爱思唯尔版权所有