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| 甲状腺旁腺激素调节乳汁中钙含量并通过钙调整新生儿骨的形成 |
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| Parathyroid hormone contributes to regulating milk calcium content and modulates neonatal bone formation cooperatively with calcium |
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| Cao G., Gu Z., Ren Y., Shu L., Tao C., Karaplis A., Goltzman D., Miao D. 2009/5/29 18:38:57 |
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Endocrinology, 2009, Volume 150, Issue 2
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| To determine whether PTH and calcium (Ca) interact in neonatal bone formation, female lactating mice either heterozygous (PTH+/-) or homozygous (PTH-/-) for targeted deletion of the pth gene were fed either a normal (1% Ca, 0.6% phosphate) or high-Ca diet (2% Ca and 0.4% phosphate). Dietary effects on milk Ca content and Ca-regulating hormones were determined in dams, and the effects of milk content were assessed on bone turnover in 3-wk-old pups. On the normal diet, milk Caand 1, 25-dihydroxyvitamin D3 levels were lower, but milk PTH-related protein levels were higher in the PTH-/- dams compared with the PTH+/- dams. On the high-Ca diet, milk Ca levels were higher, but milk 1,25-dihydroxyvitamin D3 and PTH-related protein levels were lower in both PTH +/- and PTH-/- dams. In pups fed by PTH-/- dams compared with pups fed by PTH+/- dams on normal diets, bone mineral density, trabecular bone volume relative to tissue volume, and the number of osteoblasts were reduced in both PTH+/- (32.5 ± 1.2 vs. 39.6 ± 1.5 mg/cm2, P < 0.05; 23.3 ± 1.6 vs. 29.2 ± 2.8%, P < 0.01; and 94.2 ± 8.2 vs. 123.5 ± 3.5/mm2, P < 0.01, respectively) and PTH-/- (20.4 ± 0.9 vs. 27.0 ± 1.2 mg/mm2, P < 0.05; 16.8 ± 1.9 vs. 19.3 ± 2.1%, P lt; 0.05; and 48.6 ± 7.9 vs. 90.5 ± 8.6/mm2, P < 0.01, respectively) pups but were lower in the PTH-/- pups compared with the PTH+/- pups. In contrast, in pups fed by either PTH+/- or PTH-/- dams on the high-Ca diet, bone mineral density, bone volume/tissue volume, and osteoblast numbers were significantly higher, in both PTH+/- (50.5 ± 1.7 vs. 58.7 ± 2.0 mg/mm2, P < 0.05; 37.9 ± 5.2 vs. 46.1 ± 5.1, P lt; 0.05; and 120.5 ± 9.2 vs. 159.3 ± 14.7/mm2, P < 0.01, respectively) and PTH-/- (33.0 ± 1.2 vs. 47.5 ± 2.2 mg/mm2, P < 0.001;23.8 ± 3.1 vs. 35.9 ± 2.0, P < 0.05; and 78.7 ± 10.1 vs. 99.8 ± 13.6/mm2, P < 0.05, respectively), and were highest in the PTH+/- pups fed by the PTH+/- dams on the high-Ca diet. These results indicatethat PTH can modulate Ca content of milk, and that PTH and Ca can each exert cooperative roles on osteoblastic bone formation in the neonate. Copyright © 2009 by The Endocrine Society. |
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| Correspondence Address: Miao, D.; Department of Anatomy, Histology and Embryology, Research Center for Bone and Stem Cells, Nanjing Medical University, Nanjing, Jiangsu 210029, China; email: dsmiao@njmu.edu.cn |
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 疾病资源中心
王燕燕 王曙
上海交通大学附属瑞金医院内分泌科
患者，女，69岁。2009年1月无明显诱因下出现乏力，当时程度较轻，未予以重视。2009年3月患者乏力症状加重，尿色逐渐加深，大便习惯改变，颜色变淡。4月18日入我院感染科治疗，诉轻度头晕、心慌，体重减轻10kg。无肝区疼痛，无发热，无腹痛、腹泻、腹胀、里急后重，无恶性、呕吐等。入院半月前于外院就诊，查肝功能：ALT 601IU/L，AST 785IU/L，TBIL 97.7umol/L，白蛋白 41g/L，甲状腺功能：游离T3 30.6pmol/L，游离T4 51.9pmol/L，心电图示快速房颤。
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