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| 葛根素治疗急性缺血性卒中 |
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| Puerarin for acute ischaemic stroke |
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| Tan Y., Liu M., Wu B. 2009/5/29 18:39:20 |
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Cochrane Database of Systematic Reviews, 2008, Volume 0, Issue 1
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| Background: Puerarin, a form of herbal medicine, is widely used in the treatment of acute ischaemic stroke in China. Objectives: To assess the efficacy and safety of puerarin in patients with acute ischaemic stroke. Search strategy: We searched the Cochrane Stroke Group Trials Register (last searched August 2006), the Trials Register of the Cochrane Complementary Medicine Field (last searched June 2006) and the Chinese Stroke Trials Register (last searched June 2006). In addition, we searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 1, 2006), MEDLINE (1966 to August 2006), EMBASE (1980 to June 2006), AMED (1985 to June 2006) and the China Biological Medicine Database (CBM-disc, 1979 to June 2006). We searched reference lists, relevant clinical trials and research registers and contacted pharmaceutical companies and researchers in an effort to identify further published and unpublished studies. Selection criteria: Randomised controlled trials or quasi-randomised controlled clinical trials comparing puerarin with placebo or open control (no placebo) in patients with acute ischaemic stroke. Data collection and analysis: Two review authors independently applied the inclusion criteria, assessed trial quality and extracted the data. Main results: One trial, involving 98 participants, was included. No significant difference in death or dependency was shown between the treatment and control groups (odds ratio (OR) 0.81; 95% confidence interval (CI) 0.35 to 1.87). No serious adverse effects were reported. Authors' conclusions: There is not enough evidence to evaluate the effect of puerarin on survival or dependency of patients with acute ischaemic stroke. High-quality and large-scale randomised controlled trials are needed to assess its efficacy. Copyright © 2008 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. |
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| Correspondence Address: Liu, M.; Department of Neurology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu Sichuan Province 610041, China; email: wyplmh@hotmail.com |
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 疾病资源中心
王燕燕 王曙
上海交通大学附属瑞金医院内分泌科
患者，女，69岁。2009年1月无明显诱因下出现乏力，当时程度较轻，未予以重视。2009年3月患者乏力症状加重，尿色逐渐加深，大便习惯改变，颜色变淡。4月18日入我院感染科治疗，诉轻度头晕、心慌，体重减轻10kg。无肝区疼痛，无发热，无腹痛、腹泻、腹胀、里急后重，无恶性、呕吐等。入院半月前于外院就诊，查肝功能：ALT 601IU/L，AST 785IU/L，TBIL 97.7umol/L，白蛋白 41g/L，甲状腺功能：游离T3 30.6pmol/L，游离T4 51.9pmol/L，心电图示快速房颤。
医学数据库
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