中国作者重要发表 - 在可行手术切除治疗的非小细胞肺癌台湾患者中表皮生长因子受体、KRAS 基因突变和表皮生长因子受体基因拷贝数的预后价值



在可行手术切除治疗的非小细胞肺癌台湾患者中表皮生长因子受体、KRAS 基因突变和表皮生长因子受体基因拷贝数的预后价值





Prognostic implications of epidermal growth factor receptor and KRAS gene mutations and epidermal growth factor receptor gene copy numbers in patients with surgically resectable non-small cell lung cancer in Taiwan





Liu H-P, Isaac Wu H-D, Chang JW-C, Wu Y-C, Yang H-Y, Chen Y-T, Hsieh W-Y, Chen Y-T, Chen Y-R, Huang S-F 2010/9/13 15:02:00

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Journal of Thoracic Oncology, 2010, Volume 5, Issue 8




inhibitor for tumor recurrence, the trends were still the same. Patients with KRAS mutations had shorter median survival (21 months) than wild type (44.4 months). Patients with EGFR polysomy (≥copies) also had longer median survival (56.2 months) than wild type (53.4 months). But the survival differences of these two genetic markers were all not significant statistically. Conclusion: It is intriguing that patients with NSCLC with EGFR mutations had better survival than wild type. Such a tumor biology may confound the survival data in a study without the stratification by EGFR mutation. © 2010 by the International Association for the Study of Lung Cancer.



Correspondence Address: Huang, S.-F.; Division of Molecular and Genomic Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli 35053, Taiwan; email:sfhuang@nhri.org.tw



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疾病资源中心

高血压	慢性阻塞性肺病
脂肪性肝病	糖尿病
卒中	肺癌
冠心病	子宫内膜异位症
结直肠癌	乳腺癌
心力衰竭	心律失常

病例分析

甲状腺功能亢进合并黄疸

王燕燕王曙

上海交通大学附属瑞金医院内分泌科

患者，女，69岁。2009年1月无明显诱因下出现乏力，当时程度较轻，未予以重视。2009年3月患者乏力症状加重，尿色逐渐加深，大便习惯改变，颜色变淡。4月18日入我院感染科治疗，诉轻度头晕、心慌，体重减轻10kg。无肝区疼痛，无发热，无腹痛、腹泻、腹胀、里急后重，无恶性、呕吐等。入院半月前于外院就诊，查肝功能：ALT 601IU/L，AST 785IU/L，TBIL 97.7umol/L，白蛋白 41g/L，甲状腺功能：游离T3 30.6pmol/L，游离T4 51.9pmol/L，心电图示快速房颤。

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