中国作者重要发表 - 姜黄素或地塞米松在大鼠肺缺血-再灌注损伤中的作用



姜黄素或地塞米松在大鼠肺缺血-再灌注损伤中的作用





Effects of curcumin or dexamethasone on lung ischaemia-reperfusion injury in rats





Sun J., Yang D., Li S., Xu Z., Wang X., Bai C. 2009/5/29 18:39:31

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European Respiratory Journal, 2009, Volume 33, Issue 2




The present study aimed to investigate potential effects of curcumin (CUR) and dexamethasone (DXM) on ischaemia-reperfusion (I/R) induced lung injury in rats. Experimental rats were pre-treated with a single i.p. dose of vehicle, CUR (50 mgkg-1 or 200 mgkg-1) or DXM (5 mgkg-1), 2 h before anaesthesia and subjected to left lung hilus clamping with 90-min ischaemia followed by 4 h of reperfusion. Pre-treatment with CUR (200 mgkg -1) or DXM markedly attenuated I/R-induced barrier disruption, lung oedema, tissue inflammation, hypoxaemia 4 h after reperfusion, and over- activation of nuclear factor-κB, inflammatory cytokines, myeloperoxidase and malondialdehyde. It appears that curcumin attenuates acute lung injury, probably through improving oxidative stress and inhibiting nuclear factor-κB-mediated expression of inflammatory cytokines. Thus, curcumin may be an alternative therapy for improving the outcomes of ischaemia- reperfusion-induced lung injury. Copyright © ERS Journals Ltd 2009.



Correspondence Address: Bai, C.; Dept. of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai 200032, China; email: bai.chunxue@zs-hospital.sh.cn



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