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| 肝细胞核因子常见变体ip和中国人2型糖尿病有关 |
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| Common variants of hepatocyte nuclear factor ip are associated with type 2 diabetes in a chinese population |
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| Wang C., Hu C., Zhang R., Bao Y., Xiaojing M., Lu J., Qin W., Shao X., Lu J., Xu I., Lu H., Xiang K., Jia W. 2009/5/29 18:38:57 |
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Diabetes, 2009, Volume 58, Issue 4
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| OBJECTIVE-Hepatocyte nuclear factor 1β (HNF1β)isa transcription factor that is critical for pancreatic cell formation and glucose homeostasis. Previous studies have reported that common variants of HNF1 β were associated with type 2 diabetes in Caucasians and West Africans. However, analysis in the subjects from the Botnia study and Malmö Preventive Project produced conflicting results, and the role for HNF1β in type 2 diabetes susceptibility remains unclear. We therefore investigated common variants across the HNF1β gene in a Chinese population. RESEARCH DESIGN AND METHODS-Fifteen tagging single nucleotide polymorphisms (SNPs) were analyzed for association with type 2 diabetes in subjects with type 2 diabetes (n = 1,859) and normal glucose regulation (n = 1,785). RESULTS-Consistent with the initial study, we observed evidence that the risk G allele of rs4430796 in intron 2 was significantly associated with type 2 diabetes (odds ratio 1.16 [95% CI 1.05-1.29], P = 0.0035, empirical P = 0.0475). Furthermore, the at-risk G allele was associated with earlier age at diagnosis in the type 2 diabetic subjects (P = 0.0228). CONCLUSIONS-The result of this study provides evidence that variants in the HNF1 β region contribute to susceptibility to type 2 diabetes in the Chinese population. © 2009 by the American Diabetes Association. |
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| Correspondence Address: Jia, W.; Department of Endocrinology and Metabolism, Shanghai Jiao Tong University, Sixth People's Hospital, Shanghai, China; email: wpjia@sjtu.edu.cn |
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 疾病资源中心
王燕燕 王曙
上海交通大学附属瑞金医院内分泌科
患者，女，69岁。2009年1月无明显诱因下出现乏力，当时程度较轻，未予以重视。2009年3月患者乏力症状加重，尿色逐渐加深，大便习惯改变，颜色变淡。4月18日入我院感染科治疗，诉轻度头晕、心慌，体重减轻10kg。无肝区疼痛，无发热，无腹痛、腹泻、腹胀、里急后重，无恶性、呕吐等。入院半月前于外院就诊，查肝功能：ALT 601IU/L，AST 785IU/L，TBIL 97.7umol/L，白蛋白 41g/L，甲状腺功能：游离T3 30.6pmol/L，游离T4 51.9pmol/L，心电图示快速房颤。
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