中国作者重要发表 - 人蜕膜间质细胞来源的条件培养液对滋养细胞侵袭具有浓度依赖的影响



人蜕膜间质细胞来源的条件培养液对滋养细胞侵袭具有浓度依赖的影响





Conditioned Medium from Human Decidual Stromal Cells has a Concentration-dependent Effect on Trophoblast Cell Invasion





Zhu X.M., Han T., Sargent I.L., Wang Y.L., Yao Y.Q. 2009/5/29 18:39:42

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Placenta, 2009, Volume 30, Issue 1




The regulation of trophoblast cell invasion is a crucial aspect of implantation and placental development. Evidence indicates that the uterine microenvironment exerts important influence over trophoblast cell invasion. However, the precise effect of decidual cells on trophoblast cell invasion remained unidentified. In the present study, a cell line representative of normal human trophoblast (B6Tert) was used to examine the effect of decidual stromal cell conditioned media (DSCM) on trophoblast cell invasion. In vitro assay showed the concentration-dependent effect of DSCM on B6Tert cell invasion. RT-PCR and gelatin zymography demonstrated that DSCM evidently produced an effect on the mRNA expression and proenzyme production of MMP-2 in a dose-dependent manner, but exerted no effect on mRNA expression and proenzyme production of MMP-9. The data indicates that the decidual microenvironment may exert the key control for trophoblast cell invasion mainly through influencing MMP-2 expression. © 2008 Elsevier Ltd. All rights reserved.



Correspondence Address: Yao, Y.Q.; Department of Obstetrics and Gynecology, Tangdu Hospital, The Fourth Military Medical University, Xinsi Road, Xi'an, 710038, China; email: rao_yu_zxm@hotmail.com



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王燕燕王曙

上海交通大学附属瑞金医院内分泌科

患者，女，69岁。2009年1月无明显诱因下出现乏力，当时程度较轻，未予以重视。2009年3月患者乏力症状加重，尿色逐渐加深，大便习惯改变，颜色变淡。4月18日入我院感染科治疗，诉轻度头晕、心慌，体重减轻10kg。无肝区疼痛，无发热，无腹痛、腹泻、腹胀、里急后重，无恶性、呕吐等。入院半月前于外院就诊，查肝功能：ALT 601IU/L，AST 785IU/L，TBIL 97.7umol/L，白蛋白 41g/L，甲状腺功能：游离T3 30.6pmol/L，游离T4 51.9pmol/L，心电图示快速房颤。

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