|
|
|
|
| 内嗅区皮层的脑沟形态与阿尔茨海默病相关 |
|
|
|
|
|
| An entorhinal cortex sulcal pattern is associated with alzheimer's disease |
|
|
|
|
|
| Zhan J., Brys M., Glodzik L., Tsui W., Javier E., Wegiel J., Kuchna I., Pirraglia E., Li Y., Mosconi L., Louis L.A.S., Switalski R., De Santi S., Kim B.C., Wisniewski T., Reisberg B., Bobinski M., De Leon M.J. 2009/5/29 18:40:20 |
|
|
【发表评论】
|
|
|
|
|
打印|
推荐给好友
|
|
|
Human Brain Mapping, 2009, Volume 30, Issue 3
|
|
|
|
|
|
|
| Objectives: Magnetic resonance (MRI) studies rely on sulcal boundaries to delineate the human entorhinal cortex (EC) and typically show that EC size is reduced in Alzheimer's disease (AD) and a predictor of future dementia. However, it is unknown if variations in the EC sulcal patterns are associated with AD. We classified the lateral EC sulcal boundary as either a rhinal or collateral pattern and tested the hypotheses that the rhinal pattern was (1) more common in AD and (z) associated with a smaller EC size. Experimental Design: MRI was used to determine the prevalence of the rhinal and collateral EC patterns in 421 subjects (212 AD, 107 old normal (ONL), and 102 young NL (YNL). Anatomical validation studies of normal subjects were conducted at postmortem in 34 brain hemispheres and in vivo with 21 MRI volume studies. EC pattern reliability was studied with MRI in both cross-sectional and longitudinal designs. Principal Observations: The rhinal pattern was more frequent in the right hemisphere in AD (47%) compared with ONL (28%, odds ratio = 2.25, P = 0.001). EC pattern was not related to ApoE genotype. The validations showed that the EC sulcal pattern was not associated with the neuronal number, surface area, or volume of the EC. In patients with antemortem MRI studied at postmortem it was equivalently determined, that EC patterns are reliably determined on MRI and do not change with the progressive atrophy of AD. Conclusions: The data indicate that the right hemisphere rhinal pattern is over represented in AD as compared with control. However, in normal subjects the EC rhinal pattern is not associated with a diminished EC tissue size. It remains to be demonstrated if the right EC rhinal sulcus pattern association with AD reflects genetic or developmental influences. © 2008 Wiley-Liss, Inc. |
|
|
|
|
|
|
| Correspondence Address: De Leon, M. J.; Department of Psychiatry (MHL400), NYU School of Medicine, 560 First Avenue, New York, NY 10016; email: mony.deleon@med.nyu.edu |
|
|
|
|
|
|
|
|
|
|
|
请登录后发表评论，点击此处登录。
|
|
|
 疾病资源中心
王燕燕 王曙
上海交通大学附属瑞金医院内分泌科
患者，女，69岁。2009年1月无明显诱因下出现乏力，当时程度较轻，未予以重视。2009年3月患者乏力症状加重，尿色逐渐加深，大便习惯改变，颜色变淡。4月18日入我院感染科治疗，诉轻度头晕、心慌，体重减轻10kg。无肝区疼痛，无发热，无腹痛、腹泻、腹胀、里急后重，无恶性、呕吐等。入院半月前于外院就诊，查肝功能：ALT 601IU/L，AST 785IU/L，TBIL 97.7umol/L，白蛋白 41g/L，甲状腺功能：游离T3 30.6pmol/L，游离T4 51.9pmol/L，心电图示快速房颤。
医学数据库
|
