中国作者重要发表 - 神经细胞命运决定的表观遗传学机制



神经细胞命运决定的表观遗传学机制





Epigenetic background of neuronal fate determination





Wen S., Li H., Liu J. 2009/5/29 18:40:20

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Progress in Neurobiology, 2009, Volume 87, Issue 2




The development of the central nervous system (CNS) starts from neural stem cells (NSCs). During this process, NSCs are specified in space- and time-related fashions, becoming spatially heterogeneous and generating a progressively restricted repertoire of cell types: neurons, astrocytes and oligodendrocytes. The processes of neurodevelopment are determined reciprocally by intrinsic and external factors which interface to program and re-program the profiling of fate-determination gene expression. Multiple signaling pathways act in a dynamic web mode to determine the fate of NSCs through modulating the activity of a distinct set of transcription factors which in turn trigger the transcription of neural fate-determination genes. Accumulating evidence reveals that during CNS development, multiple epigenetic factors regulate the activities of extracellular signaling and corresponding transcription factors in a coordinative manner, leading to the formation of a system with sophisticated structure and magic functions. This review aims to introduce recent advances in the epigenetic background of neural cell fate determination. © 2008 Elsevier Ltd. All rights reserved.



Correspondence Address: Liu, J.; Department of Cell Biology, College of Basic Medical Sciences, Dalian Medical University, 116044 Dalian, Liaoning, China; email:jialiudl@yahoo.com.cn



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