急性消化性溃疡出血治疗方面的挑战(综述)

Challenges in the management of acute peptic ulcer bleeding ( Review )
作者:Lau, J.Y.W., Barkun, A., Fan, D.-M. ,Kuipers, E.J.
机构: 香港中文大学消化疾病研究所
期刊: Lancet2013年7月9882期381卷

Institute of Digestive Diseases, Chinese University of Hong Kong, Hong Kong, Hong Kong

 

Acute upper gastrointestinal bleeding is a common medical emergency worldwide, a major cause of which are bleeding peptic ulcers. Endoscopic treatment and acid suppression with proton-pump inhibitors are cornerstones in the management of the disease, and both treatments have been shown to reduce mortality. The role of emergency surgery continues to diminish. In specialised centres, radiological intervention is increasingly used in patients with severe and recurrent bleeding who do not respond to endoscopic treatment. Despite these advances, mortality from the disorder has remained at around 10%. The disease often occurs in elderly patients with frequent comorbidities who use antiplatelet agents, non-steroidal anti-inflammatory drugs, and anticoagulants. The management of such patients, especially those at high cardiothrombotic risk who are on anticoagulants, is a challenge for clinicians. We summarise the published scientific literature about the management of patients with bleeding peptic ulcers, identify directions for future clinical research, and suggest how mortality can be reduced.

 

Lau, J.Y.W.; Institute of Digestive Diseases, Chinese University of Hong Kong, Hong Kong, Hong Kong;

通讯作者:Lau, J.Y.W.; Institute of Digestive Diseases, Chinese University of Hong Kong, Hong Kong, Hong Kong; email:laujyw@surgery.cuhk.edu.hk
学科代码:内科学   关键词:acute peptic ulcer bleeding
来源: Scopus
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