白细胞免疫球蛋白样受体A3(LILRA3)对系统性红斑狼疮和干燥综合征易感性和亚表型的影响

Impact of the leucocyte immunoglobulin-like receptor A3 (LILRA3) on susceptibility and subphenotypes of systemic lupus erythematosus and Sj?gren's syndrome
2015-11-12 08:42发表评论
作者:Du, Y., Su, Y., He, J., Yang, Y., Shi, Y., Cui, Y., Luo, C., Wu, X., Liu, X., Hu, F., Ma, X., Zheng, L., Zhang, J., Zuo, X., Sheng, Y., Wu, L., Zhang, X., Guo, J. , Li, Z.
机构: 北京大学人民医院风湿免疫科
期刊: ANN RHEUM DIS2015年11月11期74卷

Background: Recently, our research group identified the non-deleted (functional) leucocyte immunoglobulinlike receptor A3 (LILRA3) as a new genetic risk for rheumatoid arthritis. Objectives: To further investigate whether the functional LILRA3 is a new susceptibility factor for other autoimmune diseases-for example, systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS). Methods: The LILRA3 deletion polymorphism and its tagging single nucleotide polymorphism rs103294 were genotyped for 1099 patients with SLE, 403 patients with pSS and 2169 healthy controls. Association analyses were performed in whole dataset or clinical/serological subsets. The impact of LILRA3 on SLE activity and LILRA3 expression was evaluated. Results: The functional LILRA3 conferred high susceptibility to both SLE (p=3.51×10-7, OR=2.03) and pSS (p=1.40×10-3, OR=2.32). It was associated with almost all the clinical/serological features in SLE, especially with leucopenia (p=4.09×10-7, OR=2.19) and thrombocytopenia (p=1.68×10-5, OR=1.70). In pSS, functional LILRA3 was specifically associated with leucopenia (p=4.39×10-4, OR=3.25), anti-Ro/SSApositive subphenotypes (p=4.54×10-3, OR=2.34) and anti-La/SSB-positive subphenotypes (p=0.012, OR=2.49). Functional LILRA3 conferred higher disease activity in patients with SLE (p=0.044) and higher LILRA3 expression in both SLE (p=5.57×10-8) and pSS (p=1.49×10-7) than in controls. Conclusions: Functional LILRA3 is a new susceptibility factor for SLE and pSS. It highly predisposes to certain phenotypes such as leucopenia and thrombocytopenia in SLE, and may confer increased disease activity in SLE and a higher risk of leucopenia and autoantibodypositive subphenotypes in pSS.

 

 

通讯机构:Department of Rheumatology and Immunology, Peking University, People's Hospital, 11 South Xizhimen Street, Beijing, China
学科代码:风湿病学   关键词:白细胞免疫球蛋白样受体A3 系统性红斑狼疮 干燥综合征 ,中国作者重要发表 爱思唯尔医学网, Elseviermed
来源: Scopus
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