甲状旁腺素相关蛋白对软骨细胞肥大的抑制功能：对关节软骨修复的意义

Ouyang, H.W.; Center for for Stem Cell and Tissue Engineering, School of Medicine, Zhejiang University, Hangzhou, 310058, China; email:hwoy@zju.edu.cn

Cartilage repair tissue is usually accompanied by chondrocyte hypertrophy and osseous overgrowths, and a role for parathyroid hormone-related protein (PTHrP) in inhibiting chondrocytes from hypertrophic differentiation during the process of endochondral ossification has been demonstrated. However, application of PTHrP in cartilage repair has not been extensively considered. This review systemically summarizes for the first time the inhibitory function of PTHrP on chondrocyte hypertrophy in articular cartilage and during the process of endochondral ossification, as well as the process of mesenchymal stem cell chondrogenic differentiation. Based on the literature review, the strategy of using PTHrP for articular cartilage repair is suggested, which is instructive for clinical treatment of cartilage injuries as well as osteoarthritis. © 2012 BioMed Central Ltd.

Center for for Stem Cell and Tissue Engineering, School of Medicine, Zhejiang University, Hangzhou, 310058, China