茶碱+沙美特罗/氟替卡松丙酸酯联合治疗对哮喘患者的效果

Efficacy of theophylline plus salmeterol/fluticasone propionate combination therapy in patients with asthma
作者:Nie, H.a , Zhang, G.b, Liu, M.a, Ding, X.a, Huang,
机构: 武汉大学人民医院呼吸内科
期刊: RESP MED2013年3月3期107卷

Department of Respiratory Medicine, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang District, Wuhan 430060, China

Objective: To compare the efficacy of theophylline plus salmeterol/fluticasone propionate combination product (SFC) with SFC plus placebo in asthmatic patients. Methods: In this randomized, stratified, parallel-group study, 325 patients were randomized to receive either 200 mg theophylline plus 50/250 μg SFC or placebo tablet plus 50/250 μg SFC twice daily for 24 weeks. Outcome variables included the level of asthma control (assessed by the Asthma Control Test) and the number of patients experiencing ≥1 exacerbations during the 24-week treatment period. Testing of lung function as well as measurement of the levels of inflammatory markers in induced sputum was performed. Results: There were significantly fewer patients with ≥1 asthma exacerbation in the theophylline plus SFC group (29.6%) when compared with the SFC plus placebo group (46.9%) (p = 0.004). Theophylline plus SFC improved the FEF25-75% value, which indicates enhanced small airway function, to a greater extent than SFC plus placebo (66.9 ± 18.8% and 57.4 ± 17.6%, respectively; p < 0.001). A significant decrease in eosinophil count and concentration of eosinophil cationic protein in induced sputum was also seen in the theophylline plus SFC group when compared with the SFC plus placebo group (4.1 ± 2.2% and 6.3 ± 2.7%, 63.6 ± 39.5 μg/L and 89.4 ± 45.6 μg/L, respectively; all p < 0.01). Conclusion: The combination of theophylline plus SFC may provide greater protection against asthma exacerbations, and its administration is accompanied by significant improvements in small airway function and airway inflammation. © 2012 Published by Elsevier Ltd.

Nie, H.; Department of Respiratory Medicine, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang District, Wuhan 430060, China; email:nhxiang@yahoo.cn

通讯作者:Nie, H.; Department of Respiratory Medicine, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang District, Wuhan 430060, China; email:nhxiang@yahoo.cn
学科代码:呼吸病学   关键词:Theophylline_plus_salmeterolfl
来源: Scopus
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