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Clinical Chemistry
(Clin Chem) 《临床化学》

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临床化学
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Published 2013年1月,Volume 59,Issue 1

最新一期


    • Eleftherios P. Diamandis, 
    • Robert C. Bast, Jr., 
    • and Carlos Lopez-Otín

    Conquering Cancer in Our Lifetime: New Diagnostic and Therapeutic Trends

    Clinical Chemistry 2013; v. 59, p.1-3. Published November 30, 2012.
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Editorials

    • Ulf-Håkan Stenman

    Validating Serum Markers for Monitoring of Cancer

    Clinical Chemistry 2013; v. 59, p.4-5. Published October 31, 2012.
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    • Charles Swanton

    Plasma-Derived Tumor DNA Analysis at Whole-Genome Resolution

    Clinical Chemistry 2013; v. 59, p.6-8. Published October 31, 2012.
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    • Carsten Stephan and
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    • Klaus Jung

    TMPRSS2-ERG Fusion Transcripts in Matched Urine and Needle Rinse Material after Biopsy for the Detection of Prostate Cancer: Really a Step Forward?

    Clinical Chemistry 2013; v. 59, p.9-10. Published November 7, 2012.
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Interview

    • Misia Landau

    An Interview with Ronald DePinho

    Clinical Chemistry 2013; v. 59, p.11-17.
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Reflections

    • Jennifer Jennings and
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    • Thomas J. Hudson

    Reflections on the Founding of the International Cancer Genome Consortium

    Clinical Chemistry 2013; v. 59, p.18-21. Published November 7, 2012.
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    • Eleftherios P. Diamandis, 
    • Robert C. Bast, Jr., 
    • Phil Gold, 
    • T. Ming Chu,
    • and John L. Magnani

    Reflection on the Discovery of Carcinoembryonic Antigen, Prostate-Specific Antigen, and Cancer Antigens CA125 and CA19-9

    Clinical Chemistry 2013; v. 59, p.22-31. Published November 30, 2012.
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    • Harry Rittenhouse, 
    • Amy Blase, 
    • Blair Shamel, 
    • Jack Schalken, 
    • and Jack Groskopf

    The Long and Winding Road to FDA Approval of a Novel Prostate Cancer Test: Our Story

    Clinical Chemistry 2013; v. 59, p.32-34. Published November 28, 2012.
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Perspectives

    • Danijela Konforte and
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    • Eleftherios P. Diamandis

    Is Early Detection of Cancer with Circulating Biomarkers Feasible?

    Clinical Chemistry 2013; v. 59, p.35-37. Published April 20, 2012.
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    • Carol J. Farhangfar, 
    • Funda Meric-Bernstam, 
    • John Mendelsohn, 
    • Gordon B. Mills,
    • and Agda Karina Lucio-Eterovic

    The Impact of Tumor Heterogeneity on Patient Treatment Decisions

    Clinical Chemistry 2013; v. 59, p.38-40. Published November 9, 2012.
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Q&A

    • Caitlin C. Chrystoja, 
    • Eleftherios P. Diamandis, 
    • Randall Brand, 
    • Felix Rückert,
    • Randy Haun, 
    • and Rafael Molina

    Pancreatic Cancer

    Clinical Chemistry 2013; v. 59, p.41-46. Published November 7, 2012.
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Clinical Case Study

    • Eva C. Guinan and
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    • Suneet Agarwal

    A Young Adult with Aplastic Anemia and Gray Hair

    Clinical Chemistry 2013; v. 59, p.47-50.
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  • Commentaries

      • Todd E. Druley

      Commentary

      Clinical Chemistry 2013; v. 59, p.50-51.
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      • Timothy S. Olson and
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      • Monica Bessler

      Commentary

      Clinical Chemistry 2013; v. 59, p.51.
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Special Report

    • György Sölétormos, 
    • Michael J. Duffy, 
    • Daniel F. Hayes, 
    • Catharine M. Sturgeon,
    • Vivian Barak, 
    • Patrick M. Bossuyt, 
    • Eleftherios P. Diamandis, 
    • Massimo Gion,
    • Per Hyltoft-Petersen, 
    • Rolf M. Lamerz, 
    • Dorte L. Nielsen, 
    • Paul Sibley,
    • Bengt Tholander, 
    • Malgorzata K. Tuxen, 
    • and Johannes M.G. Bonfrer

    Design of Tumor Biomarker–Monitoring Trials: A Proposal by the European Group on Tumor Markers

    Clinical Chemistry 2013; v. 59, p.52-59. Published October 3, 2012.
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Mini-Reviews

    • Sudhir Srivastava

    The Early Detection Research Network: 10-Year Outlook

    Clinical Chemistry 2013; v. 59, p.60-67. Published November 16, 2012.
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    • Ziding Feng, 
    • Jacob Kagan, 
    • Margaret Pepe, 
    • Mark Thornquist, 
    • Jo Ann Rinaudo,
    • Jackie Dahlgren, 
    • Karl Krueger, 
    • Yingye Zheng, 
    • Christos Patriotis, 
    • Ying Huang,
    • Lynn Sorbara, 
    • Ian Thompson, 
    • and Sudhir Srivastava

    The Early Detection Research Network's Specimen Reference Sets: Paving the Way for Rapid Evaluation of Potential Biomarkers

    Clinical Chemistry 2013; v. 59, p.68-74. Published November 27, 2012.
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    • Roberta Ferraldeschi, 
    • Gerhardt Attard, 
    • and Johann S. de Bono

    Novel Strategies to Test Biological Hypotheses in Early Drug Development for Advanced Prostate Cancer

    Clinical Chemistry 2013; v. 59, p.75-84. Published November 30, 2012.
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    • Nor Eddine Sounni and
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    • Agnès Noel

    Targeting the Tumor Microenvironment for Cancer Therapy

    Clinical Chemistry 2013; v. 59, p.85-93. Published November 28, 2012.
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    • Sherri L. Patterson, 
    • Karen Colbert Maresso, 
    • and Ernest Hawk

    Cancer Chemoprevention: Successes and Failures

    Clinical Chemistry 2013; v. 59, p.94-101. Published November 13, 2012.
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    • Vijay Modur, 
    • Eric Hailman, 
    • and J.C. Barrett

    Evidence-Based Laboratory Medicine in Oncology Drug Development: From Biomarkers to Diagnostics

    Clinical Chemistry 2013; v. 59, p.102-109. Published October 3, 2012.
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    • Catherine Alix-Panabières and
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    • Klaus Pantel

    Circulating Tumor Cells: Liquid Biopsy of Cancer

    Clinical Chemistry 2013; v. 59, p.110-118. Published September 26, 2012.
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Reviews

    • Ayumu Taguchi and
    •  
    • Samir M. Hanash

    Unleashing the Power of Proteomics to Develop Blood-Based Cancer Markers

    Clinical Chemistry 2013; v. 59, p.119-126. Published October 24, 2012.
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    • Nardin Samuel and
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    • Thomas J. Hudson

    Translating Genomics to the Clinic: Implications of Cancer Heterogeneity

    Clinical Chemistry 2013; v. 59, p.127-137. Published November 14, 2012.
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    • Omran Abu Aboud and
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    • Robert H. Weiss

    New Opportunities from the Cancer Metabolome

    Clinical Chemistry 2013; v. 59, p.138-146. Published November 13, 2012.
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    • Maria P. Pavlou, 
    • Eleftherios P. Diamandis, 
    • and Ivan M. Blasutig

    The Long Journey of Cancer Biomarkers from the Bench to the Clinic

    Clinical Chemistry 2013; v. 59, p.147-157. Published September 27, 2012.
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    • Maria D. Pasic, 
    • Sara Samaan, 
    • and George M. Yousef

    Genomic Medicine: New Frontiers and New Challenges

    Clinical Chemistry 2013; v. 59, p.158-167.
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    • Nemanja D. Marjanovic, 
    • Robert A. Weinberg, 
    • and Christine L. Chaffer

    Cell Plasticity and Heterogeneity in Cancer

    Clinical Chemistry 2013; v. 59, p.168-179. Published December 6, 2012.
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    • Robert R. Langley and
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    • Isaiah J. Fidler

    The Biology of Brain Metastasis

    Clinical Chemistry 2013; v. 59, p.180-189. Published October 31, 2012.
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Opinions

    • Laura Esserman, 
    • Elissa Ozanne, 
    • and Laura van't Veer

    Will Early Detection for Breast Cancer Ever Work?

    Clinical Chemistry 2013; v. 59, p.190-193. Published November 27, 2012.
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    • N. Leigh Anderson, 
    • Adam S. Ptolemy, 
    • and Nader Rifai

    The Riddle of Protein Diagnostics: Future Bleak or Bright?

    Clinical Chemistry 2013; v. 59, p.194-197. Published November 13, 2012.
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    • J. Carl Barrett, 
    • Melanie M. Frigault, 
    • Simon Hollingsworth, 
    • Glenn A. Miller,
    • and Vijay Modur

    Are Companion Diagnostics Useful?

    Clinical Chemistry 2013; v. 59, p.198-201. Published November 28, 2012.
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    • John P.A. Ioannidis

    Biomarker Failures

    Clinical Chemistry 2013; v. 59, p.202-204. Published September 20, 2012.
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Point/Counterpoint

    • Ebrahim Azizi and
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    • Max S. Wicha

    Point: Cancer Stem Cells—The Evidence Accumulates

    Clinical Chemistry 2013; v. 59, p.205-207. Published November 9, 2012.
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    • Yesim Gökmen-Polar and
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    • Sunil S. Badve

    Counterpoint: Cancer Stem Cells: Nonbelievers' Viewpoint

    Clinical Chemistry 2013; v. 59, p.208-210. Published November 7, 2012.
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Articles

Cancer Diagnostics

    • K.C. Allen Chan, 
    • Peiyong Jiang, 
    • Yama W.L. Zheng, 
    • Gary J.W. Liao, 
    • Hao Sun,
    • John Wong, 
    • Shing Shun N. Siu, 
    • Wing C. Chan, 
    • Stephen L. Chan,
    • Anthony T.C. Chan, 
    • Paul B.S. Lai, 
    • Rossa W.K. Chiu, 
    • and Y.M.D. Lo

    Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing

    Clinical Chemistry 2013; v. 59, p.211-224. Published October 11, 2012.
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    • [Journal Club]
    • Nora Berois, 
    • Charles-Henry Gattolliat, 
    • Enrique Barrios, 
    • Laura Capandeguy,
    • Sétha Douc-Rasy, 
    • Dominique Valteau-Couanet, 
    • Jean Bénard, 
    • and Eduardo Osinaga

    GALNT9 Gene Expression Is a Prognostic Marker in Neuroblastoma Patients

    Clinical Chemistry 2013; v. 59, p.225-233. Published November 7, 2012.
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    • Santiago Rodriguez, 
    • Osama A. Al-Ghamdi, 
    • Kimberley Burrows, 
    • Philip A.I. Guthrie,
    • J. Athene Lane, 
    • Michael Davis, 
    • Gemma Marsden, 
    • Khalid K. Alharbi, 
    • Angela Cox,
    • Freddie C. Hamdy, 
    • David E. Neal, 
    • Jenny L. Donovan, 
    • and Ian N.M. Day

    Very Low PSA Concentrations and Deletions of the KLK3 Gene

    Clinical Chemistry 2013; v. 59, p.234-244. Published November 20, 2012.
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    • Phuong-Nhi Bories, 
    • Patrick Younes, 
    • Marc Zerbib, 
    • Lydie Denjean, 
    • Theodora Popovici,
    • Luc Cynober, 
    • and Nicolas Barry Delongchamps

    TMPRSS2-ERG Fusion Transcripts in Matched Urine and Needle Rinse Material after Biopsy for the Detection of Prostate Cancer

    Clinical Chemistry 2013; v. 59, p.245-251. Published October 8, 2012.
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    • Christin Gasch, 
    • Thomas Bauernhofer, 
    • Martin Pichler, 
    • Sabine Langer-Freitag,
    • Matthias Reeh, 
    • Adrian M. Seifert, 
    • Oliver Mauermann, 
    • Jakob R. Izbicki, 
    • Klaus Pantel,
    • and Sabine Riethdorf

    Heterogeneity of Epidermal Growth Factor Receptor Status and Mutations ofKRAS/PIK3CA in Circulating Tumor Cells of Patients with Colorectal Cancer

    Clinical Chemistry 2013; v. 59, p.252-260. Published November 7, 2012.
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    • Konstantinos Mavridis, 
    • Konstantinos Stravodimos, 
    • and Andreas Scorilas

    Downregulation and Prognostic Performance of MicroRNA 224 Expression in Prostate Cancer

    Clinical Chemistry 2013; v. 59, p.261-269. Published November 7, 2012.
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    • Maria Chimonidou, 
    • Areti Strati, 
    • Nikos Malamos, 
    • Vasilis Georgoulias,
    • and Evi S. Lianidou

    SOX17 Promoter Methylation in Circulating Tumor Cells and Matched Cell-Free DNA Isolated from Plasma of Patients with Breast Cancer

    Clinical Chemistry 2013; v. 59, p.270-279. Published November 7, 2012.
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    • [Journal Club]
    • Carsten Stephan, 
    • Klaus Jung, 
    • Axel Semjonow, 
    • Kai Schulze-Forster,
    • Henning Cammann, 
    • Xinhai Hu, 
    • Hellmuth-A. Meyer, 
    • Martin Bögemann, 
    • Kurt Miller,
    • and Frank Friedersdorff

    Comparative Assessment of Urinary Prostate Cancer Antigen 3 andTMPRSS2:ERG Gene Fusion with the Serum [−2]Proprostate-Specific Antigen–Based Prostate Health Index for Detection of Prostate Cancer

    Clinical Chemistry 2013; v. 59, p.280-288. Published December 4, 2012.
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    • Kumiko Mori, 
    • Shinobu Sato, 
    • Masaaki Kodama, 
    • Manabu Habu, 
    • Osamu Takahashi,
    • Tatsuji Nishihara, 
    • Kazuhiro Tominaga, 
    • and Shigeori Takenaka

    Oral Cancer Diagnosis via a Ferrocenylnaphthalene Diimide–Based Electrochemical Telomerase Assay

    Clinical Chemistry 2013; v. 59, p.289-295. Published November 7, 2012.
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    • Jane Bayani, 
    • Uros Kuzmanov, 
    • Punit Saraon, 
    • William A. Fung,
    • Antoninus Soosaipillai, 
    • Jeremy A. Squire, 
    • and Eleftherios P. Diamandis

    Copy Number and Expression Alterations of miRNAs in the Ovarian Cancer Cell Line OVCAR-3: Impact on Kallikrein 6 Protein Expression

    Clinical Chemistry 2013; v. 59, p.296-305. Published November 7, 2012.
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    • Carsten Stephan, 
    • Sébastien Vincendeau, 
    • Alain Houlgatte, 
    • Henning Cammann,
    • Klaus Jung, 
    • and Axel Semjonow

    Multicenter Evaluation of [−2]Proprostate-Specific Antigen and the Prostate Health Index for Detecting Prostate Cancer

    Clinical Chemistry 2013; v. 59, p.306-314. Published December 4, 2012.
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Proteomics and Protein Markers

    • Danni Li, 
    • Hanching Chiu, 
    • Jing Chen, 
    • Hui Zhang, 
    • and Daniel W. Chan

    Integrated Analyses of Proteins and Their Glycans in a Magnetic Bead–Based Multiplex Assay Format

    Clinical Chemistry 2013; v. 59, p.315-324. Published October 24, 2012.
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Citation Classic

    • Frank J. Slack

    MicroRNAs Regulate Expression of Oncogenes

    Clinical Chemistry 2013; v. 59, p.325-326. Published April 23, 2012.
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Letter to the Editor

    • Sukhbinder Dhesy-Thind, 
    • Vikaash Kumar, 
    • Aidan Snider-McNair, 
    • Colleen Shortt,
    • Som D. Mukherjee, 
    • Peter Ellis, 
    • Gregory R. Pond, 
    • and Peter A. Kavsak

    Cardiac and Inflammation Biomarker Profile after Initiation of Adjuvant Trastuzumab Therapy

    Clinical Chemistry 2013; v. 59, p.327-329. Published September 20, 2012.
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Clinical Chemist

Unveiling the Right Side

    • Usha Anand

    Tumor Markers

    Clinical Chemistry 2013; v. 59, p.330-331.
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News & Views

  • Call for Nominations

    Clinical Chemistry 2013; v. 59, p.331.
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Quo Vadis?

  • Quo Vadis?

    Clinical Chemistry 2013; v. 59, p.332.
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Science in the Arts

    • Marek H. Dominiczak

    Illness and Culture: Maggie's Centres

    Clinical Chemistry 2013; v. 59, p.333-334.
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    Clin Chem 临床化学
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    amer assoc clinical chemistry
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