Journal of Clinical Investigation
(J CLIN INVEST) 《临床研究杂志》
2015年影响因子
12.575
期刊介绍
《临床研究杂志》是生物医学领域重要进展的顶尖集散地之一。除了以刊登有重要影响的研究论文之外，这本期刊还接受简报和新技术的投稿。
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- 2015-06-18•IRX1低甲基化通过诱导CXCL14/NF-κB 信号通路促进骨肉瘤转移
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目录导读
Published 2013年8月,Volume 123,Issue 8
最新一期
Conversations With Giants In Medicine
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A conversation with John Oates *
Ushma S. Neill
Full text | PDF (Page 3186)
A tribute to Emil Frei III
Edward J. Benz Jr., David G. Nathan
Full text | PDF (Page 3188)
Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer *
Jonathan Welti, Sonja Loges, Stefanie Dimmeler, Peter Carmeliet
Abstract | Full text | PDF | Supplemental material (Page 3190)
Collagenases and cracks in the plaque *
Peter Libby
Abstract | Full text | PDF (Page 3201)
Rapamycin, anti-aging, and avoiding the fate of Tithonus *
Arlan Richardson
Abstract | Full text | PDF (Page 3204)
The future of molecular chaperones and beyond *
Rona G. Giffard, Alberto J.L. Macario, Everly Conway de Macario
Abstract | Full text | PDF (Page 3206)
Chronic THC intake modifies fundamental cerebellar functions *
Nephi Stella
Abstract | Full text | PDF (Page 3208)
Colon cancer progression is driven by APEX1-mediated upregulation of Jagged
Mi-Hwa Kim, Hong-Beum Kim, Sang Pil Yoon, Sung-Chul Lim, Man Jin Cha, Young Jin Jeon, Sang Gon Park, In-Youb Chang, Ho Jin You
Abstract | Full text | PDF | Supplemental material (Page 3211)
MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis
Rebecca S. Cook, Kristen M. Jacobsen, Anne M. Wofford, Deborah DeRyckere, Jamie Stanford, Anne L. Prieto, Elizabeth Redente, Melissa Sandahl, Debra M. Hunter, Karen E. Strunk, Douglas K. Graham, H. Shelton Earp III
Abstract | Full text | PDF | Supplemental material (Page 3231)
ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling
Heon Yung Gee, Pawaree Saisawat, Shazia Ashraf, Toby W. Hurd, Virginia Vega-Warner, Humphrey Fang, Bodo B. Beck, Olivier Gribouval, Weibin Zhou, Katrina A. Diaz, Sivakumar Natarajan, Roger C. Wiggins, Svjetlana Lovric, Gil Chernin, Dominik S. Schoeb, Bugsu Ovunc, Yaacov Frishberg, Neveen A. Soliman, Hanan M. Fathy, Heike Goebel, Julia Hoefele, Lutz T. Weber, Jeffrey W. Innis, Christian Faul, Zhe Han, Joseph Washburn, Corinne Antignac, Shawn Levy, Edgar A. Otto, Friedhelm Hildebrandt
Abstract | Full text | PDF | Supplemental material (Page 3243)
Whole body correction of mucopolysaccharidosis IIIA by intracerebrospinal fluid gene therapy
Virginia Haurigot, Sara Marcó, Albert Ribera, Miguel Garcia, Albert Ruzo, Pilar Villacampa, Eduard Ayuso, Sònia Añor, Anna Andaluz, Mercedes Pineda, Gemma García-Fructuoso, Maria Molas, Luca Maggioni, Sergio Muñoz, Sandra Motas, Jesús Ruberte, Federico Mingozzi, Martí Pumarola, Fatima Bosch
Abstract | Full text | PDF | Supplemental material (Page 3254)
Rapamycin extends murine lifespan but has limited effects on aging
Frauke Neff, Diana Flores-Dominguez, Devon P. Ryan, Marion Horsch, Susanne Schröder, Thure Adler, Luciana Caminha Afonso, Juan Antonio Aguilar-Pimentel, Lore Becker, Lillian Garrett, Wolfgang Hans, Moritz M. Hettich, Richard Holtmeier, Sabine M. Hölter, Kristin Moreth, Cornelia Prehn, Oliver Puk, Ildikó Rácz, Birgit Rathkolb, Jan Rozman, Beatrix Naton, Rainer Ordemann, Jerzy Adamski, Johannes Beckers, Raffi Bekeredjian, Dirk H. Busch, Gerhard Ehninger, Jochen Graw, Heinz Höfler, Martin Klingenspor, Thomas Klopstock, Markus Ollert, Jörg Stypmann, Eckhard Wolf, Wolfgang Wurst, Andreas Zimmer, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabe de Angelis, Dan Ehninger
Abstract | Full text | PDF | Supplemental material (Page 3272)
Developmental differences in IFN signaling affect GATA1s-induced megakaryocyte hyperproliferation
Andrew J. Woo, Karen Wieland, Hui Huang, Thomas E. Akie, Taylor Piers, Jonghwan Kim, Alan B. Cantor
Abstract | Full text | PDF | Supplemental material (Page 3292)
Inactivation of specific β cell transcription factors in type 2 diabetes
Shuangli Guo, Chunhua Dai, Min Guo, Brandon Taylor, Jamie S. Harmon, Maike Sander, R. Paul Robertson, Alvin C. Powers, Roland Stein
Abstract | Full text | PDF | Supplemental material (Page 3305)
β-globin gene transfer to human bone marrow for sickle cell disease
Zulema Romero, Fabrizia Urbinati, Sabine Geiger, Aaron R. Cooper, Jennifer Wherley, Michael L. Kaufman, Roger P. Hollis, Rafael Ruiz de Assin, Shantha Senadheera, Arineh Sahagian, Xiangyang Jin, Alyse Gellis, Xiaoyan Wang, David Gjertson, Satiro DeOliveira, Pamela Kempert, Sally Shupien, Hisham Abdel-Azim, Mark C. Walters, Herbert J. Meiselman, Rosalinda B. Wenby, Theresa Gruber, Victor Marder, Thomas D. Coates, Donald B. Kohn
Abstract | Full text | PDF | Supplemental material (Page 3317)
Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice
Carsten Deppermann, Deya Cherpokova, Paquita Nurden, Jan-Niklas Schulz, Ina Thielmann, Peter Kraft, Timo Vögtle, Christoph Kleinschnitz, Sebastian Dütting, Georg Krohne, Sabine A. Eming, Alan T. Nurden, Beate Eckes, Guido Stoll, David Stegner, Bernhard Nieswandt
Abstract | Full text | PDF | Supplemental material (Page 3331)
Immunoglobulin-like domain containing receptor 1 mediates fat-stimulated cholecystokinin secretion
Rashmi Chandra, Yu Wang, Rafiq A. Shahid, Steven R. Vigna, Neil J. Freedman, Rodger A. Liddle
Abstract | Full text | PDF | Supplemental material (Page 3343)
Cross-species malaria immunity induced by chemically attenuated parasites
Michael F. Good, Jennifer M. Reiman, I. Bibiana Rodriguez, Koichi Ito, Stephanie K. Yanow, Ibrahim M. El-Deeb, Michael R. Batzloff, Danielle I. Stanisic, Christian Engwerda, Terry Spithill, Stephen L. Hoffman, Moses Lee, Virginia McPhun
Abstract | Full text | PDF | Supplemental material (Page 3353)
Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes
Joanna M. Warszawska, Riem Gawish, Omar Sharif, Stefanie Sigel, Bianca Doninger, Karin Lakovits, Ildiko Mesteri, Manfred Nairz, Louis Boon, Alexander Spiel, Valentin Fuhrmann, Birgit Strobl, Mathias Müller, Peter Schenk, Günter Weiss, Sylvia Knapp
Abstract | Full text | PDF | Supplemental material (Page 3363)
BRIEF REPORT Cerebrovascular degradation of TRKB by MMP9 in the diabetic brain
Deepti Navaratna, Xiang Fan, Wendy Leung, Josephine Lok, Shuzhen Guo, Changhong Xing, Xiaoying Wang, Eng H. Lo
Abstract | Full text | PDF | Supplemental material (Page 3373)
BRIEF REPORT Atrial natriuretic peptide is negatively regulated by microRNA-425
Pankaj Arora, Connie Wu, Abigail May Khan, Donald B. Bloch, Brandi N. Davis-Dusenbery, Anahita Ghorbani, Ester Spagnolli, Andrew Martinez, Allicia Ryan, Laurel T. Tainsh, Samuel Kim, Jian Rong, Tianxiao Huan, Jane E. Freedman, Daniel Levy, Karen K. Miller, Akiko Hata, Federica del Monte, Sara Vandenwijngaert, Melissa Swinnen, Stefan Janssens, Tara M. Holmes, Emmanuel S. Buys, Kenneth D. Bloch, Christopher Newton-Cheh, Thomas J. Wang
Abstract | Full text | PDF | Supplemental material (Page 3378)
CLINICAL MEDICINE IL-12p70–producing patient DC vaccine elicits Tc1-polarized immunity
Beatriz M. Carreno, Michelle Becker-Hapak, Alexander Huang, Megan Chan, Amer Alyasiry, Wen-Rong Lie, Rebecca L. Aft, Lynn A. Cornelius, Kathryn M. Trinkaus, Gerald P. Linette
Abstract | Full text | PDF | Supplemental material (Page 3383)
Cold acclimation recruits human brown fat and increases nonshivering thermogenesis
Anouk A.J.J. van der Lans, Joris Hoeks, Boudewijn Brans, Guy H.E.J. Vijgen, Mariëlle G.W. Visser, Maarten J. Vosselman, Jan Hansen, Johanna A. Jörgensen, Jun Wu, Felix M. Mottaghy, Patrick Schrauwen, Wouter D. van Marken Lichtenbelt
Abstract | Full text | PDF | Supplemental material (Page 3395)
BRIEF REPORT Recruited brown adipose tissue as an antiobesity agent in humans
Takeshi Yoneshiro, Sayuri Aita, Mami Matsushita, Takashi Kayahara, Toshimitsu Kameya, Yuko Kawai, Toshihiko Iwanaga, Masayuki Saito
Abstract | Full text | PDF | Supplemental material (Page 3404)
FOXOs attenuate bone formation by suppressing Wnt signaling
Srividhya Iyer, Elena Ambrogini, Shoshana M. Bartell, Li Han, Paula K. Roberson, Rafael de Cabo, Robert L. Jilka, Robert S. Weinstein, Charles A. O’Brien, Stavros C. Manolagas, Maria Almeida
Abstract | Full text | PDF | Supplemental material (Page 3409)
The nucleotide sugar UDP-glucose mobilizes long-term repopulating primitive hematopoietic cells
Sungho Kook, Joonseok Cho, Sean Bong Lee, Byeong-Chel Lee
Abstract | Full text | PDF | Supplemental material (Page 3420)
Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis
Tilman Ziegler, Jan Horstkotte, Claudia Schwab, Vanessa Pfetsch, Karolina Weinmann, Steffen Dietzel, Ina Rohwedder, Rabea Hinkel, Lisa Gross, Seungmin Lee, Junhao Hu, Oliver Soehnlein, Wolfgang M. Franz, Markus Sperandio, Ulrich Pohl, Markus Thomas, Christian Weber, Hellmut G. Augustin, Reinhard Fässler, Urban Deutsch, Christian Kupatt
Abstract | Full text | PDF | Supplemental material (Page 3436)
Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis
Jonathan Cools-Lartigue, Jonathan Spicer, Braedon McDonald, Stephen Gowing, Simon Chow, Betty Giannias, France Bourdeau, Paul Kubes, Lorenzo Ferri
Abstract | Full text | PDF | Supplemental material (Page 3446)
Metastasis-associated PRL-3 induces EGFR activation and addiction in cancer cells
Abdul Qader Omer Al-aidaroos, Hiu Fung Yuen, Ke Guo, Shu Dong Zhang, Tae-Hoon Chung, Wee Joo Chng, Qi Zeng
Abstract | Full text | PDF | Supplemental material (Page 3459)
Macrophages regulate corpus luteum development during embryo implantation in mice
Alison S. Care, Kerrilyn R. Diener, Melinda J. Jasper, Hannah M. Brown, Wendy V. Ingman, Sarah A. Robertson
Abstract | Full text | PDF | Supplemental material (Page 3472)
LXRβ/estrogen receptor-α signaling in lipid rafts preserves endothelial integrity
Tomonori Ishikawa, Ivan S. Yuhanna, Junko Umetani, Wan-Ru Lee, Kenneth S. Korach, Philip W. Shaul, Michihisa Umetani
Abstract | Full text | PDF | Supplemental material (Page 3488)
Collagen VII plays a dual role in wound healing
Alexander Nyström, Daniela Velati, Venugopal R. Mittapalli, Anja Fritsch, Johannes S. Kern, Leena Bruckner-Tuderman
Abstract | Full text | PDF | Supplemental material (Page 3498)
Medullary thymic epithelial cell depletion leads to autoimmune hepatitis
Anthony J. Bonito, Costica Aloman, M. Isabel Fiel, Nichole M. Danzl, Sungwon Cha, Erica G. Weinstein, Seihwan Jeong, Yongwon Choi, Matthew C. Walsh, Konstantina Alexandropoulos
Abstract | Full text | PDF | Supplemental material (Page 3510)
FGFR2 signaling underlies p63 oncogenic function in squamous cell carcinoma
Matthew R. Ramsey, Catherine Wilson, Benjamin Ory, S. Michael Rothenberg, William Faquin, Alea A. Mills, Leif W. Ellisen
Abstract | Full text | PDF | Supplemental material (Page 3525)
A link between FTO, ghrelin, and impaired brain food-cue responsivity
Efthimia Karra, Owen G. O’Daly, Agharul I. Choudhury, Ahmed Yousseif, Steven Millership, Marianne T. Neary, William R. Scott, Keval Chandarana, Sean Manning, Martin E. Hess, Hiroshi Iwakura, Takashi Akamizu, Queensta Millet, Cigdem Gelegen, Megan E. Drew, Sofia Rahman, Julian J. Emmanuel, Steven C.R. Williams, Ulrich U. Rüther, Jens C. Brüning, Dominic J. Withers, Fernando O. Zelaya, Rachel L. Batterham
Abstract | Full text | PDF | Supplemental material (Page 3539)
Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis
Rebecca L. Williams-Karnesky, Ursula S. Sandau, Theresa A. Lusardi, Nikki K. Lytle, Joseph M. Farrell, Eleanor M. Pritchard, David L. Kaplan, Detlev Boison
Abstract | Full text | PDF | Supplemental material (Page 3552)
Transcription factor EGR1 directs tendon differentiation and promotes tendon repair
Marie-Justine Guerquin, Benjamin Charvet, Geoffroy Nourissat, Emmanuelle Havis, Olivier Ronsin, Marie-Ange Bonnin, Mathilde Ruggiu, Isabel Olivera-Martinez, Nicolas Robert, Yinhui Lu, Karl E. Kadler, Tristan Baumberger, Levon Doursounian, Francis Berenbaum, Delphine Duprez
Abstract | Full text | PDF | Supplemental material (Page 3564)
Inner ear supporting cells protect hair cells by secreting HSP70
Lindsey A. May, Inga I. Kramarenko, Carlene S. Brandon, Christina Voelkel-Johnson, Soumen Roy, Kristy Truong, Shimon P. Francis, Elyssa L. Monzack, Fu-Shing Lee, Lisa L. Cunningham
Abstract | Full text | PDF (Page 3577)
CHIP protects against cardiac pressure overload through regulation of AMPK
Jonathan C. Schisler, Carrie E. Rubel, Chunlian Zhang, Pamela Lockyer, Douglas M. Cyr, Cam Patterson
Abstract | Full text | PDF | Supplemental material (Page 3588)
FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension
Edda Spiekerkoetter, Xuefei Tian, Jie Cai, Rachel K. Hopper, Deepti Sudheendra, Caiyun G. Li, Nesrine El-Bizri, Hirofumi Sawada, Roxanna Haghighat, Roshelle Chan, Leila Haghighat, Vinicio de Jesus Perez, Lingli Wang, Sushma Reddy, Mingming Zhao, Daniel Bernstein, David E. Solow-Cordero, Philip A. Beachy, Thomas J. Wandless, Peter ten Dijke, Marlene Rabinovitch
Abstract | Full text | PDF | Supplemental material (Page 3600)
Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response
Chanté L. Richardson, Lorrie L. Delehanty, Grant C. Bullock, Claudia M. Rival, Kenneth S. Tung, Donald L. Kimpel, Sara Gardenghi, Stefano Rivella, Adam N. Goldfarb
Abstract | Full text | PDF | Supplemental material (Page 3614)
Somitic disruption of GNAS in chick embryos mimics progressive osseous heteroplasia
Dana M. Cairns, Robert J. Pignolo, Tomoya Uchimura, Tracy A. Brennan, Carter M. Lindborg, Meiqi Xu, Frederick S. Kaplan, Eileen M. Shore, Li Zeng
Abstract | Full text | PDF | Supplemental material (Page 3624)
Targeting autophagy potentiates tyrosine kinase inhibitor–induced cell death in Philadelphia chromosome–positive cells, including primary CML stem cells
Cristian Bellodi, Maria Rosa Lidonnici, Ashley Hamilton, G. Vignir Helgason, Angela Rachele Soliera, Mattia Ronchetti, Sara Galavotti, Kenneth W. Young, Tommaso Selmi, Rinat Yacobi, Richard A. Van Etten, Nick Donato, Ann Hunter, David Dinsdale, Elena Tirrò, Paolo Vigneri, Pierluigi Nicotera, Martin J. Dyer, Tessa Holyoake, Paolo Salomoni, Bruno Calabretta
Full text | PDF (Page 3634)
Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling
Katsuhiko Funai, Haowei Song, Li Yin, Irfan J. Lodhi, Xiaochao Wei, Jun Yoshino, Trey Coleman, Clay F. Semenkovich
Full text | PDF (Page 3634)
Rare variants in single-minded 1 (SIM1) are associated with severe obesity
Shwetha Ramachandrappa, Anne Raimondo, Anna M.G. Cali, Julia M. Keogh, Elana Henning, Sadia Saeed, Amanda Thompson, Sumedha Garg, Elena G. Bochukova, Soren Brage, Victoria Trowse, Eleanor Wheeler, Adrienne E. Sullivan, Mehul Dattani, Peter E. Clayton, Vipan Datta, John B. Bruning, Nick J. Wareham, Stephen O’Rahilly, Daniel J. Peet, Ines Barroso, Murray L. Whitelaw, I. Sadaf Farooqi
Full text | PDF (Page 3635)
BM mesenchymal stromal cell–derived exosomes facilitate multiple myeloma progression
Aldo M. Roccaro, Antonio Sacco, Patricia Maiso, Abdel Kareem Azab, Yu-Tzu Tai, Michaela Reagan, Feda Azab, Ludmila M. Flores, Federico Campigotto, Edie Weller, Kenneth C. Anderson, David T. Scadden, Irene M. Ghobrial
Full text | PDF (Page 3635)
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