Developmental Biology
(DEV_BIOL ) 《Developmental Biology》
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2012年影响因子
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Published 2013年2月,Volume 374,Issue 1
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Research Articles
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A novel FoxD3 gene trap line reveals neural crest precursor movement and a role for FoxD3 in their specificationOriginal Research ArticlePages 1-11 Tatiana Hochgreb-Hägele, Marianne E. Bronner
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A quantitative model of normal Caenorhabditis elegans embryogenesis and its disruption after stressOriginal Research ArticlePages 12-23 Julia L. Richards, Amanda L. Zacharias, Travis Walton, Joshua T. Burdick, John Isaac Murray
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Highlights
► We develop improved automated lineage tracing tools for Caenorhabditis elegans embryos. ► We generate a model of embryogenesis and provide a 3D software viewer. ► Variability of cell cycle length, division orientation and position is low. ► Specific classes of cells have increased variability. ► Embryonic variability increases nonlinearly with temperature.
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Phospholipase C gamma-1 is required for granulocyte maturation in zebrafishOriginal Research ArticlePages 24-31 Chang-Bin Jing, Yi Chen, Mei Dong, Xiao-Lan Peng, Xiao-E Jia, Lei Gao, Ke Ma, Min Deng, Ting-Xi Liu, Leonard I. Zon, Jun Zhu, Yi Zhou, Yong Zhou
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Highlights
► We found a zebrafish mutant line with specific decreased mpx expression in ICM region. ► We indentified that the plcg1 gene was responsible for the mutant phenotypes. ► Depletion of plcg1 specifically affected granulocyte maturation process.
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Neural differentiation of fragile X human embryonic stem cells reveals abnormal patterns of development despite successful neurogenesisOriginal Research ArticlePages 32-45 Michael Telias, Menahem Segal, Dalit Ben-Yosef
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Highlights
► FX-hESC can differentiate in-vitro into bona-fide neurons. ► Neurogenesis of FX-hESCs recapitulates the in-vivo process of FMR1 downregulation. ► Aberrant development was found already at the early stages of neurogenesis. ► FX neurons express action potentials, but lack synaptic activity.
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CDC42 is required for structural patterning of the lung during developmentOriginal Research ArticlePages 46-57 Huajing Wan, Caijun Liu, Susan E. Wert, Wei Xu, Yong Liao, Yi Zheng, Jeffrey A. Whitsett
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Highlights
► CDC42 controls spatial positioning of epithelial cells during lung morphogenesis. ► CDC42 controls the transition of the epithelium from pseudostratified to columnar. ► Directional trafficking of critical epithelial proteins is dependent on CDC42. ► CDC42 modulated SHH/FGF signaling, factors critical for patterning lung structure.
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The combinatorial guidance activities of draxin and Tsukushi are essential for forebrain commissure formationOriginal Research ArticlePages 58-70 Mahmud Hossain, Giasuddin Ahmed, Iftekhar Bin Naser, Yohei Shinmyo, Ayako Ito, M. Asrafuzzaman Riyadh, Athary Felemban, Xiaohong Song, Kunimasa Ohta, Hideaki Tanaka
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Highlights
► draxin and Tsukushi (TSK) interact genetically. ► draxin/TSK doubly heterozygous mice show high frequency malformation of the corpus callosum. ► The anterior commissure is absent in draxin/TSK doubly heterozygous mice. ► TSK is a novel repulsive axon guidance molecule for cortical and AON axons. ► The neurite-outgrowth-inhibiting effects of TSK and draxin are additive.
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Multi-modal effects of BMP signaling on Nodal expression in the lateral plate mesoderm during left–right axis formation in the chick embryoOriginal Research ArticlePages 71-84 Kenjiro Katsu, Norifumi Tatsumi, Daisuke Niki, Ken-ichi Yamamura, Yuji Yokouchi
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Highlights
► Different BMP signal levels differentially regulate Nodal expression in the LPM. ► High and low intermediate levels of BMP signaling induce Nodal expression. ► Low and high intermediate levels of BMP signaling inhibit Nodal expression. ► BMP signaling and NODAL signaling compete for SMAD4 to regulate Nodal expression.
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ENC1-like integrates the retinoic acid/FGF signaling pathways to modulate ciliogenesis of Kupffer’s vesicle during zebrafish embryonic developmentOriginal Research ArticlePages 85-95 Meilin Qian, Shaohua Yao, Lulu Jing, Jiao He, Chun Xiao, Ting Zhang, Wentong Meng, Hongyan Zhu, Hong Xu, Xianming Mo
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Highlights
► Cilia-driven counterclockwise fluid flow in zebrafish Kupffer’s Vesicle (KV) resulted in left–right patterning during embryonic development. ► We find that Ectoderm-Neural Cortex 1-like (enc1l) is necessary for KV ciliogenesis in zebrafish embryo development. ► Loss-of-function of enc1l increased the number and decreased the length of KV cilia. ► The enc1l expression in the KV region was specifically regulated by retinoic acid (RA), FGF, and Wnt signaling pathways. ► Accordingly, knocking down Enc1l or ectopic enc1lexpression was able to rescue the KV cilium defects caused by alteration of RA and FGF signaling, but not Wnt signaling. ► These data indicate that Enc1l is a direct downstream effector of RA and FGF signaling pathways and modulates KV ciliogenesis in the zebrafish embryo.
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Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesisOriginal Research ArticlePages 96-107 Chang Jin, Jing Chen, Qinghang Meng, Vinicius Carreira, Neville N.C. Tam, Esmond Geh, Saikumar Karyala, Shuk-Mei Ho, Xiangtian Zhou, Mario Medvedovic, Ying Xia
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Graphical abstract
Highlights
► Uncover MAP3K1-dependent transcriptome in specific subsets of developing cells. ► Expression signatures reveal patio-temporal specificity of MAP3K1 in development. ► MAP3K1 can module Wnt and Shh signaling in the eyelid closure process. ► AP2α and SRF are novel downstream transcription factors of MAP3K1 signaling.
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The Caenorhabditis elegans homolog of the Opitz syndrome gene, madd-2/Mid1, regulates anchor cell invasion during vulval developmentOriginal Research ArticlePages 108-114 Matthias K. Morf, Ivo Rimann, Mariam Alexander, Peter Roy, Alex Hajnal
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Highlights
► madd-2 is required for efficient AC invasion. ► MADD-2 regulates AC invasion in parallel with the UNC-6 Netrin pathway. ► MADD-2 prevents the formation of guidance signal-independent AC protrusions. ► Proper control of AC invasion requires both positive and negative regulation.
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Duration of Shh signaling contributes to mDA neuron diversityOriginal Research ArticlePages 115-126 Lindsay Hayes, Sherry Ralls, Hui Wang, Sohyun Ahn
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Highlights
► Shh signaling is dynamic in the vMes. ► Shh-expressing cells are derived from earlier Shh-responding cells. ► Local Shh signaling regulates the cell cycle status in the vMes. ► Duration of Shh signaling contributes to the distribution of mDA neurons in the VTA and SNc.
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Ecdysone-dependent and ecdysone-independent programmed cell death in the developing optic lobe of DrosophilaOriginal Research ArticlePages 127-141 Yusuke Hara, Keiichiro Hirai, Yu Togane, Hiromi Akagawa, Kikuo Iwabuchi, Hidenobu Tsujimura
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Highlights
► We analyzed EcR function in the developing optic lobe cell death in Drosophila. ► EcR-A and EcR-B1 have different expression profiles both in neurons and glia. ► The cell death was independent of ecdysone at prepupal stage and required no EcR isoforms. ► After 24 h APF, the cell death was dependent on ecdysone and cell-autonomously required EcR-B1.
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Discoidin domain receptors guide axons along longitudinal tracts in C. elegansOriginal Research ArticlePages 142-152 Thomas Unsoeld, Ja-On Park, Harald Hutter
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Highlights
► We characterize the role of discoidin domain receptors during neural development. ► ddr-2 mutants exhibit guidance defects in longitudinal axon tracts of C. elegans. ► ddr-1 mutants show no phenotype on their own but act synergistically with ddr-2. ► ddr-1 andddr-2 are expressed in all affected axon tracts and localize to axons. ► DDR-2 is required cell-autonomously in the ventral nerve cord pioneer neuron PVPR.
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ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor poolsOriginal Research ArticlePages 153-163 Marilia Ioannou, Ioannis Serafimidis, Luis Arnes, Lori Sussel, Surendra Singh, Vasilis Vasiliou, Anthony Gavalas
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Highlights
► Aldh1b1 was expressed in the early pancreatic buds in a Pdx1-dependent manner. ► Aldh1b1 persisting expression in the tips and trunks was partly Ngn3-dependent. ► ALDH activity in pancreatic explants was necessary for growth and lineage allocation. ► Rare centoacinar-like Aldh1b1+ cells persisted in the adult pancreas. ► Aldh1b1+ cells increased dramatically after regeneration-inducing insults.
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Wnt3 function in the epiblast is required for the maintenance but not the initiation of gastrulation in miceOriginal Research ArticlePages 164-173 Giovane G. Tortelote, J. Manuel Hernández-Hernández, Alexandre J.C. Quaresma, Jeffrey A. Nickerson, Anthony N. Imbalzano, Jaime A. Rivera-Pérez
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Highlights
► We ablate Wnt3 in the epiblast of early post-implantation mouse embryos. ► Wnt3 in the epiblast is required for maintenance but not initiation of gastrulation. ► Wnt3 activates the canonical Wnt pathway and expression of gastrulation markers. ► The canonical Wnt pathway controls activation of the Wnt3 promoter in vivo. ► We provide a contrasting view of the role of Wnt3 in axial development in mice.
Evolution of Developmental Control Mechanisms
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Changes in anterior head patterning underlie the evolution of long germ embryogenesisOriginal Research ArticlePages 174-184 Sebastian Kittelmann, Julia Ulrich, Nico Posnien, Gregor Bucher
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Graphical Abstract
Highlights
► Cap'n'collar and crocodile pattern the anterior median region of the head (AMR). ► A morphogenetic backfolding displaces anterior cells to a subterminal position. ► Huckebein does not act as terminal gap gene in Tribolium. ► Bicoid and terminal gap genes have replaced six3 as ancestral regulator of the AMR. ► Crocodile was replaced by huckebein in the control of forkhead.
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Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsulesOriginal Research ArticlePages 185-197 John N. Griffin, Claudia Compagnucci, Diane Hu, Jennifer Fish, Ophir Klein, Ralph Marcucio, Michael J. Depew
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Highlights
► We use genetic attenuation to show Fgf8 dosage dependence for cranial morphogenesis. ► Lowered Fgf8 dosage results in apoptotic changes during optic capsular development. ► Normal nasal capsule structural orientation and polarity is Fgf8 dependent. ► Midfacial integration involving the trabecular basal plate is Fgf8 dependent. ► Fgf8 attenuation leads to capsular asymmetries which has evolutionary implications.
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Evolutionary conservation of Nkx2.5 autoregulation in the second heart fieldOriginal Research ArticlePages 198-209 Christopher D. Clark, Boding Zhang, Benjamin Lee, Samuel I. Evans, Andrew B. Lassar, Kyu-Ho Lee
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Highlights
► We compared regulation of SHF enhancers of chick and mouse Nkx2.5 genes. ► We found evidence for systematic divergence of mammalian vs. avian SHF enhancers. ► Autoregulation by Nkx2.5 appears to be conserved from flies to man. ► Nkx2.5 autoregulation is necessary during differentiation of SHF progenitors. ► Nkx2.5 autoregulation requires cooperation with multiple cardiac TFs.
Genomes & Developmental Control
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Gata3 directly regulates early inner ear expression of Fgf10Original Research ArticlePages 210-222 Androulla Economou, Preeta Datta, Vassilis Georgiadis, Stephanie Cadot, Dorothy Frenz, Mark Maconochie
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Highlights
► Identify a minimal Fgf10 enhancer governing the entire inner ear expression domain. ► Three Gata3 sites in the enhancer exhibit differing affinities for Gata3 protein. ► Only one of the Gata3 sites is necessary for controlling inner ear expression. ► Gata3 is a direct upstream activator of Fgf10 in the inner ear through a single site.
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Multiple cis-elements and trans-acting factors regulate dynamic spatio-temporal transcription oflet-7 in Caenorhabditis elegansOriginal Research ArticlePages 223-233 Zoya S. Kai, Emily F. Finnegan, Stacey Huang, Amy E. Pasquinelli
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Highlights
► Transcription of let-7 from two start sites oscillates during each larval stage. ► 2 promoter elements, the TRE and LTE, have redundant and non-overlapping roles. ► The novel let-7 transcription element regulates intestinal and hypodermal expression. ► An intact TRE or LTE is essential for let-7 transcription and, hence, viability. ► Multiple trans-acting factors regulate the spatio-temporal transcription of let-7.
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Pitx1 broadly associates with limb enhancers and is enriched on hindlimb cis-regulatory elementsOriginal Research ArticlePages 234-244 Carlos R. Infante, Sungdae Park, Alexandra G. Mihala, David M. Kingsley, Douglas B. Menke
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Highlights
► Pitx1 directly regulates Tbx4 hindlimb expression. ► Pitx1 binding reveals functionally distinct subdomains of the Tbx4 HLEA enhancer. ► Pitx1 is enriched on hindlimb-specific cis-regulatory features marked by H3K27ac. ► Pitx1 associates with more than 70% of known limb enhancers. ► Pitx1 binding is enriched near genes involved in limb and skeletal development.
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Gene regulatory control in the sea urchin aboral ectoderm: Spatial initiation, signaling inputs, and cell fate lockdownOriginal Research ArticlePages 245-254 Smadar Ben-Tabou de-Leon, Yi-Hsien Su, Kuan-Ting Lin, Enhu Li, Eric H. Davidson
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Highlights
► Aboral ectoderm specification in the sea urchin embryo is controlled by multiple mechanisms. ► A redox sensitive transcription factor initiates the aboral ectoderm regulatory state. ► Two different BMP ligands provide inputs essential for continuing activity of aboral ectoderm regulatory genes. ► The aboral ectoderm regulatory state is locked down by a positive feedback wiring.
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