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In This Issue of Diabetes
Diabetes July 2013 62:2155-2156; doi:10.2337/db13-ti07
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Perspectives in Diabetes

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- Christopher J. Rhodes,
- Morris F. White,
- John L. Leahy,
- and Steven E. Kahn
Direct Autocrine Action of Insulin on β-Cells: Does It Make Physiological Sense?
Diabetes July 2013 62:2157-2163; doi:10.2337/db13-0246
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- D. Grahame Hardie
AMPK: A Target for Drugs and Natural Products With Effects on Both Diabetes and Cancer
Diabetes July 2013 62:2164-2172; doi:10.2337/db13-0368
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Commentaries

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- Dirk Jan Stenvers,
- J. Hans DeVries,
- and Susanne E. la Fleur
What’s the Time? Does the Artificial Pancreas Need to Know?
Diabetes July 2013 62:2173-2174; doi:10.2337/db13-0466
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- Jun Yoshino and
- Samuel Klein
A Novel Link Between Circadian Clocks and Adipose Tissue Energy Metabolism
Diabetes July 2013 62:2175-2177; doi:10.2337/db13-0457
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- Steven E. Kahn
Incretin Therapy and Islet Pathology: A Time for Caution
Diabetes July 2013 62:2178-2180; published ahead of print April 17, 2013, doi:10.2337/db13-0520
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- Viktor Jörgens and
- Monika Grüsser
Happy Birthday, Claude Bernard
Diabetes July 2013 62:2181-2182; doi:10.2337/db13-0700
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Metabolism

Signal Transduction

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- Jordi Lanuza-Masdeu,
- M. Isabel Arévalo,
- Cristina Vila,
- Albert Barberà,
- Ramon Gomis,
- and Carme Caelles
In Vivo JNK Activation in Pancreatic β-Cells Leads to Glucose Intolerance Caused by Insulin Resistance in Pancreas
Diabetes July 2013 62:2308-2317; published ahead of print January 24, 2013, doi:10.2337/db12-1097
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- Shaoqing Lei,
- Haobo Li,
- Jinjin Xu,
- Yanan Liu,
- Xia Gao,
- Junwen Wang,
- Kwok F.J. Ng,
- Wayne Bond Lau,
- Xin-liang Ma,
- Brian Rodrigues,
- Michael G. Irwin,
- and Zhengyuan Xia
Hyperglycemia-Induced Protein Kinase C β₂ Activation Induces Diastolic Cardiac Dysfunction in Diabetic Rats by Impairing Caveolin-3 Expression and Akt/eNOS Signaling
Diabetes July 2013 62:2318-2328; published ahead of print March 8, 2013, doi:10.2337/db12-1391
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- Sara Ramírez,
- Luís Martins,
- Jordi Jacas,
- Patricia Carrasco,
- Macarena Pozo,
- Josep Clotet,
- Dolors Serra,
- Fausto G. Hegardt,
- Carlos Diéguez,
- Miguel López,
- and Núria Casals
Hypothalamic Ceramide Levels Regulated by CPT1C Mediate the Orexigenic Effect of Ghrelin
Diabetes July 2013 62:2329-2337; published ahead of print March 14, 2013, doi:10.2337/db12-1451
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- Larbi Dridi,
- Volkan Seyrantepe,
- Anne Fougerat,
- Xuefang Pan,
- Éric Bonneil,
- Pierre Thibault,
- Allain Moreau,
- Grant A. Mitchell,
- Nikolaus Heveker,
- Christopher W. Cairo,
- Tarik Issad,
- Alexander Hinek,
- and Alexey V. Pshezhetsky
Positive Regulation of Insulin Signaling by Neuraminidase 1
Diabetes July 2013 62:2338-2346; published ahead of print March 21, 2013, doi:10.2337/db12-1825
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Obesity Studies

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- Wencheng Zhang,
- Qilong Wang,
- Ping Song,
- and Ming-Hui Zou
Liver Kinase B1 Is Required for White Adipose Tissue Growth and Differentiation
Diabetes July 2013 62:2347-2358; published ahead of print February 8, 2013, doi:10.2337/db12-1229
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- Zhiying Li,
- Sarah F. Schmidt,
- and Jeffrey M. Friedman
Developmental Role for Endocannabinoid Signaling in Regulating Glucose Metabolism and Growth
Diabetes July 2013 62:2359-2367; published ahead of print February 19, 2013, doi:10.2337/db12-0901
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- Laura M. Pérez,
- Aurora Bernal,
- Nuria San Martín,
- Margarita Lorenzo,
- Sonia Fernández-Veledo,
- and Beatriz G. Gálvez
Metabolic Rescue of Obese Adipose-Derived Stem Cells by Lin28/Let7 Pathway
Diabetes July 2013 62:2368-2379; published ahead of print February 19, 2013, doi:10.2337/db12-1220
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- Hilary E. Wilson-Pérez,
- Adam P. Chambers,
- Karen K. Ryan,
- Bailing Li,
- Darleen A. Sandoval,
- Doris Stoffers,
- Daniel J. Drucker,
- Diego Pérez-Tilve,
- and Randy J. Seeley
Vertical Sleeve Gastrectomy Is Effective in Two Genetic Mouse Models of Glucagon-Like Peptide 1 Receptor Deficiency
Diabetes July 2013 62:2380-2385; published ahead of print February 22, 2013, doi:10.2337/db12-1498
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- Christina Koutsari,
- Manpreet S. Mundi,
- Asem H. Ali,
- Bruce W. Patterson,
- and Michael D. Jensen
Systemic Free Fatty Acid Disposal Into Very Low-Density Lipoprotein Triglycerides
Diabetes July 2013 62:2386-2395; published ahead of print February 22, 2013, doi:10.2337/db12-1557
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- Yujie Li,
- Yaohui Nie,
- Ynes Helou,
- Guoxian Ding,
- Bin Feng,
- Gang Xu,
- Arthur Salomon,
- and Haiyan Xu
Identification of Sucrose Non-Fermenting–Related Kinase (SNRK) as a Suppressor of Adipocyte Inflammation
Diabetes July 2013 62:2396-2409; published ahead of print March 21, 2013, doi:10.2337/db12-1081
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- Frank A. Duca,
- Yassine Sakar,
- and Mihai Covasa
Combination of Obesity and High-Fat Feeding Diminishes Sensitivity to GLP-1R Agonist Exendin-4
Diabetes July 2013 62:2410-2415; published ahead of print February 19, 2013, doi:10.2337/db12-1204
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Islet Studies

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- Patrick P.L. Lam,
- Mitsuyo Ohno,
- Subhankar Dolai,
- Yu He,
- Tairan Qin,
- Tao Liang,
- Dan Zhu,
- Youhou Kang,
- Yunfeng Liu,
- Maria Kauppi,
- Li Xie,
- Wilson C.Y. Wan,
- Na-Rhum Bin,
- Shuzo Sugita,
- Vesa M. Olkkonen,
- Noriko Takahashi,
- Haruo Kasai,
- and Herbert Y. Gaisano
Munc18b Is a Major Mediator of Insulin Exocytosis in Rat Pancreatic β-Cells
Diabetes July 2013 62:2416-2428; published ahead of print February 19, 2013, doi:10.2337/db12-1380
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- Omid Tavana,
- Nahum Puebla-Osorio,
- Jiseong Kim,
- Mei Sang,
- Stella Jang,
- and Chengming Zhu
Ku70 Functions in Addition to Nonhomologous End Joining in Pancreatic β-Cells: A Connection to β-Catenin Regulation
Diabetes July 2013 62:2429-2438; published ahead of print March 8, 2013, doi:10.2337/db12-1218
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- Masaru Akiyama,
- Chong Wee Liew,
- Shusheng Lu,
- Jiang Hu,
- Rachael Martinez,
- Ben Hambro,
- Robert T. Kennedy,
- and Rohit N. Kulkarni
X-Box Binding Protein 1 Is Essential for Insulin Regulation of Pancreatic α-Cell Function
Diabetes July 2013 62:2439-2449; published ahead of print March 14, 2013, doi:10.2337/db12-1747
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- Nathalie M. Fiaschi-Taesch,
- Jeffrey W. Kleinberger,
- Fatimah G. Salim,
- Ronnie Troxell,
- Rachel Wills,
- Mansoor Tanwir,
- Gabriella Casinelli,
- Amy E. Cox,
- Karen K. Takane,
- Donald K. Scott,
- and Andrew F. Stewart
Human Pancreatic β-Cell G1/S Molecule Cell Cycle Atlas
Diabetes July 2013 62:2450-2459; published ahead of print March 14, 2013, doi:10.2337/db12-0777
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- Nathalie M. Fiaschi-Taesch,
- Jeffrey W. Kleinberger,
- Fatimah G. Salim,
- Ronnie Troxell,
- Rachel Wills,
- Mansoor Tanwir,
- Gabriella Casinelli,
- Amy E. Cox,
- Karen K. Takane,
- Harish Srinivas,
- Donald K. Scott,
- and Andrew F. Stewart
Cytoplasmic-Nuclear Trafficking of G1/S Cell Cycle Molecules and Adult Human β-Cell Replication: A Revised Model of Human β-Cell G1/S Control
Diabetes July 2013 62:2460-2470; published ahead of print March 14, 2013, doi:10.2337/db12-0778
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- H. Siebe Spijker,
- Raimond B.G. Ravelli,
- A. Mieke Mommaas-Kienhuis,
- Aart A. van Apeldoorn,
- Marten A. Engelse,
- Arnaud Zaldumbide,
- Susan Bonner-Weir,
- Ton J. Rabelink,
- Rob C. Hoeben,
- Hans Clevers,
- Christine L. Mummery,
- Françoise Carlotti,
- and Eelco J.P. de Koning
Conversion of Mature Human β-Cells Into Glucagon-Producing α-Cells
Diabetes July 2013 62:2471-2480; published ahead of print April 8, 2013, doi:10.2337/db12-1001
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Immunology and Transplantation

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- Mario Galgani,
- Rosa Nugnes,
- Dario Bruzzese,
- Francesco Perna,
- Veronica De Rosa,
- Claudio Procaccini,
- Enza Mozzillo,
- Corrado M. Cilio,
- Helena Elding Larsson,
- Åke Lernmark,
- Antonio La Cava,
- Adriana Franzese,
- and Giuseppe Matarese
Meta-Immunological Profiling of Children With Type 1 Diabetes Identifies New Biomarkers to Monitor Disease Progression
Diabetes July 2013 62:2481-2491; published ahead of print February 8, 2013, doi:10.2337/db12-1273
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- Ken T. Coppieters,
- Natalie Amirian,
- Philippe P. Pagni,
- Carmen Baca Jones,
- Anna Wiberg,
- Stanley Lasch,
- Edith Hintermann,
- Urs Christen,
- and Matthias G. von Herrath
Functional Redundancy of CXCR3/CXCL10 Signaling in the Recruitment of Diabetogenic Cytotoxic T Lymphocytes to Pancreatic Islets in a Virally Induced Autoimmune Diabetes Model
Diabetes July 2013 62:2492-2499; published ahead of print February 22, 2013, doi:10.2337/db12-1370
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- Paolo Monti,
- Cristina Brigatti,
- Miriam Krasmann,
- Anette G. Ziegler,
- and Ezio Bonifacio
Concentration and Activity of the Soluble Form of the Interleukin-7 Receptor α in Type 1 Diabetes Identifies an Interplay Between Hyperglycemia and Immune Function
Diabetes July 2013 62:2500-2508; published ahead of print March 1, 2013, doi:10.2337/db12-1726
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Pathophysiology

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- Monika Haemmerle,
- Thomas Keller,
- Gerda Egger,
- Helga Schachner,
- Carl Walter Steiner,
- Dejan Stokic,
- Christoph Neumayer,
- Markus K. Brown,
- Dontscho Kerjaschki,
- and Brigitte Hantusch
Enhanced Lymph Vessel Density, Remodeling, and Inflammation Are Reflected by Gene Expression Signatures in Dermal Lymphatic Endothelial Cells in Type 2 Diabetes
Diabetes July 2013 62:2509-2529; published ahead of print February 19, 2013, doi:10.2337/db12-0844
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- Cheng-Che E. Lan,
- Ching-Shuang Wu,
- Shu-Mei Huang,
- I-Hui Wu,
- and Gwo-Shing Chen
High-Glucose Environment Enhanced Oxidative Stress and Increased Interleukin-8 Secretion From Keratinocytes: New Insights Into Impaired Diabetic Wound Healing
Diabetes July 2013 62:2530-2538; published ahead of print February 19, 2013, doi:10.2337/db12-1714
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- Aimee J. Varewijck,
- Hannele Yki-Järvinen,
- Ronald Schmidt,
- Norbert Tennagels,
- and Joseph A.M.J.L. Janssen
Concentrations of Insulin Glargine and Its Metabolites During Long-Term Insulin Therapy in Type 2 Diabetic Patients and Comparison of Effects of Insulin Glargine, Its Metabolites, IGF-I, and Human Insulin on Insulin and IGF-I Receptor Signaling
Diabetes July 2013 62:2539-2544; published ahead of print April 8, 2013, doi:10.2337/db12-1773
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Complications

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- Yuguang Zhao,
- Yi Tan,
- Shugang Xi,
- Yunqian Li,
- Cai Li,
- Jiuwei Cui,
- Xiaoqing Yan,
- Xiaokun Li,
- Guanjun Wang,
- Wei Li,
- and Lu Cai
A Novel Mechanism by Which SDF-1β Protects Cardiac Cells From Palmitate-Induced Endoplasmic Reticulum Stress and Apoptosis via CXCR7 and AMPK/p38 MAPK-Mediated Interleukin-6 Generation
Diabetes July 2013 62:2545-2558; published ahead of print February 19, 2013, doi:10.2337/db12-1233
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- Qing Zhong and
- Renu A. Kowluru
Regulation of Matrix Metalloproteinase-9 by Epigenetic Modifications and the Development of Diabetic Retinopathy
Diabetes July 2013 62:2559-2568; published ahead of print February 19, 2013, doi:10.2337/db12-1141
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- Cristina Hernández,
- Marta García-Ramírez,
- Lidia Corraliza,
- Jimena Fernández-Carneado,
- Josep Farrera-Sinfreu,
- Berta Ponsati,
- Águeda González-Rodríguez,
- Ángela M. Valverde,
- and Rafael Simó
Topical Administration of Somatostatin Prevents Retinal Neurodegeneration in Experimental Diabetes
Diabetes July 2013 62:2569-2578; published ahead of print March 8, 2013, doi:10.2337/db12-0926
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- Rita E. Mirza,
- Milie M. Fang,
- William J. Ennis,
- and Timothy J. Koh
Blocking Interleukin-1β Induces a Healing-Associated Wound Macrophage Phenotype and Improves Healing in Type 2 Diabetes
Diabetes July 2013 62:2579-2587; published ahead of print March 14, 2013, doi:10.2337/db12-1450
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Pharmacology and Therapeutics

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- Aonghus O’Loughlin,
- Mangesh Kulkarni,
- Michael Creane,
- Erin E. Vaughan,
- Emma Mooney,
- Georgina Shaw,
- Mary Murphy,
- Peter Dockery,
- Abhay Pandit,
- and Timothy O’Brien
Topical Administration of Allogeneic Mesenchymal Stromal Cells Seeded in a Collagen Scaffold Augments Wound Healing and Increases Angiogenesis in the Diabetic Rabbit Ulcer
Diabetes July 2013 62:2588-2594; published ahead of print February 19, 2013, doi:10.2337/db12-1822
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- Alexandra E. Butler,
- Martha Campbell-Thompson,
- Tatyana Gurlo,
- David W. Dawson,
- Mark Atkinson,
- and Peter C. Butler
Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors
Diabetes July 2013 62:2595-2604; published ahead of print March 22, 2013, doi:10.2337/db12-1686
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Genetics/Genomes/Proteomics/Metabolomics

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- Sebastian Martini,
- Viji Nair,
- Sanjeevkumar R. Patel,
- Felix Eichinger,
- Robert G. Nelson,
- E. Jennifer Weil,
- Marcus G. Pezzolesi,
- Andrzej S. Krolewski,
- Ann Randolph,
- Benjamin J. Keller,
- Thomas Werner,
- and Matthias Kretzler
From Single Nucleotide Polymorphism to Transcriptional Mechanism: A Model for FRMD3 in Diabetic Nephropathy
Diabetes July 2013 62:2605-2612; published ahead of print February 22, 2013, doi:10.2337/db12-1416
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- Jing Luo,
- Ling Zhao,
- Aaron Yun Chen,
- Xiaohui Zhang,
- Jin Zhu,
- Jiagang Zhao,
- Hong Ouyang,
- Hongrong Luo,
- Yaojun Song,
- Janet Lee,
- Sherrina H. Patel,
- Peter X. Shaw,
- Srinivas Sadda,
- Yehong Zhuo,
- Michael G. Rosenfeld,
- and Kang Zhang
TCF7L2 Variation and Proliferative Diabetic Retinopathy
Diabetes July 2013 62:2613-2617; published ahead of print February 22, 2013, doi:10.2337/db12-1093
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- Henry A. Erlich,
- Ana Maria Valdes,
- Shana L. McDevitt,
- Birgitte B. Simen,
- Lisbeth A. Blake,
- Kim R. McGowan,
- John A. Todd,
- Stephen S. Rich,
- Janelle A. Noble,
- and for the Type 1 Diabetes Genetics Consortium (T1DGC)
Next Generation Sequencing Reveals the Association of DRB3*02:02 With Type 1 Diabetes
Diabetes July 2013 62:2618-2622; published ahead of print March 5, 2013, doi:10.2337/db12-1387
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Erratum

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- É Korpos,
- N Kadri,
- R Kappelhoff,
- J Wegner,
- CM Overall,
- E Weber,
- D Holmberg,
- S Cardell,
- and L Sorokin
The peri-islet basement membrane, a barrier to infiltrating leukocytes in type 1 diabetes in mouse and human. Diabetes 2013;62:531–542
Diabetes July 2013 62:2623; doi:10.2337/db13-er07
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Issues and Events

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Issues and Events
Diabetes July 2013 62:2624; doi:10.2337/db13-ie07
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Diabetes Digests

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Highlights From the Latest in Diabetes Research
Diabetes July 2013 62:2625-2626; doi:10.2337/db13-dd07
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Online Letters to the Editor

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- Kavaljit H. Chhabra and
- Eric Lazartigues
Comment on: Takeda et al. Loss of ACE2 Exaggerates High-Calorie Diet–Induced Insulin Resistance by Reduction of GLUT4 in Mice. Diabetes 2013;62:223–233
Diabetes July 2013 62:e9; doi:10.2337/db13-0389
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- Koichi Yamamoto,
- Masao Takeda,
- Mitsuru Ohishi,
- and Hiromi Rakugi
Response to Comment on: Takeda et al. Loss of ACE2 Exaggerates High-Calorie Diet–Induced Insulin Resistance by Reduction of GLUT4 in Mice. Diabetes 2013;62:223–233
Diabetes July 2013 62:e10; doi:10.2337/db13-0505
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In This Issue of Diabetes

Perspectives in Diabetes

Direct Autocrine Action of Insulin on β-Cells: Does It Make Physiological Sense?

AMPK: A Target for Drugs and Natural Products With Effects on Both Diabetes and Cancer

Commentaries

What’s the Time? Does the Artificial Pancreas Need to Know?

A Novel Link Between Circadian Clocks and Adipose Tissue Energy Metabolism

Incretin Therapy and Islet Pathology: A Time for Caution

Happy Birthday, Claude Bernard

Metabolism

Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance

Circadian Regulation of Lipid Mobilization in White Adipose Tissues

Hyperglycemia Mediates a Shift From Cap-Dependent to Cap-Independent Translation Via a 4E-BP1–Dependent Mechanism

Amelioration of Hypoglycemia Via Somatostatin Receptor Type 2 Antagonism in Recurrently Hypoglycemic Diabetic Rats

Diurnal Pattern of Insulin Action in Type 1 Diabetes: Implications for a Closed-Loop System

Central Activating Transcription Factor 4 (ATF4) Regulates Hepatic Insulin Resistance in Mice via S6K1 Signaling and the Vagus Nerve

Mechanisms Underlying the Onset of Oral Lipid–Induced Skeletal Muscle Insulin Resistance in Humans

Moderate GLUT4 Overexpression Improves Insulin Sensitivity and Fasting Triglyceridemia in High-Fat Diet–Fed Transgenic Mice

Exercise Prevents Fructose-Induced Hypertriglyceridemia in Healthy Young Subjects

Histidine Augments the Suppression of Hepatic Glucose Production by Central Insulin Action

miRNA-93 Inhibits GLUT4 and Is Overexpressed in Adipose Tissue of Polycystic Ovary Syndrome Patients and Women With Insulin Resistance

High- and Moderate-Intensity Training Normalizes Ventricular Function and Mechanoenergetics in Mice With Diet-Induced Obesity

Extracellular Signal–Regulated Kinase in the Ventromedial Hypothalamus Mediates Leptin-Induced Glucose Uptake in Red-Type Skeletal Muscle

Signal Transduction

In Vivo JNK Activation in Pancreatic β-Cells Leads to Glucose Intolerance Caused by Insulin Resistance in Pancreas

Hyperglycemia-Induced Protein Kinase C β2 Activation Induces Diastolic Cardiac Dysfunction in Diabetic Rats by Impairing Caveolin-3 Expression and Akt/eNOS Signaling

Hypothalamic Ceramide Levels Regulated by CPT1C Mediate the Orexigenic Effect of Ghrelin

Positive Regulation of Insulin Signaling by Neuraminidase 1

Obesity Studies

Liver Kinase B1 Is Required for White Adipose Tissue Growth and Differentiation

Developmental Role for Endocannabinoid Signaling in Regulating Glucose Metabolism and Growth

Metabolic Rescue of Obese Adipose-Derived Stem Cells by Lin28/Let7 Pathway

Vertical Sleeve Gastrectomy Is Effective in Two Genetic Mouse Models of Glucagon-Like Peptide 1 Receptor Deficiency

Systemic Free Fatty Acid Disposal Into Very Low-Density Lipoprotein Triglycerides

Identification of Sucrose Non-Fermenting–Related Kinase (SNRK) as a Suppressor of Adipocyte Inflammation

Combination of Obesity and High-Fat Feeding Diminishes Sensitivity to GLP-1R Agonist Exendin-4

Islet Studies

Munc18b Is a Major Mediator of Insulin Exocytosis in Rat Pancreatic β-Cells

Ku70 Functions in Addition to Nonhomologous End Joining in Pancreatic β-Cells: A Connection to β-Catenin Regulation

X-Box Binding Protein 1 Is Essential for Insulin Regulation of Pancreatic α-Cell Function

Human Pancreatic β-Cell G1/S Molecule Cell Cycle Atlas

Cytoplasmic-Nuclear Trafficking of G1/S Cell Cycle Molecules and Adult Human β-Cell Replication: A Revised Model of Human β-Cell G1/S Control

Conversion of Mature Human β-Cells Into Glucagon-Producing α-Cells

Immunology and Transplantation

Meta-Immunological Profiling of Children With Type 1 Diabetes Identifies New Biomarkers to Monitor Disease Progression

Functional Redundancy of CXCR3/CXCL10 Signaling in the Recruitment of Diabetogenic Cytotoxic T Lymphocytes to Pancreatic Islets in a Virally Induced Autoimmune Diabetes Model

Concentration and Activity of the Soluble Form of the Interleukin-7 Receptor α in Type 1 Diabetes Identifies an Interplay Between Hyperglycemia and Immune Function

Pathophysiology

Enhanced Lymph Vessel Density, Remodeling, and Inflammation Are Reflected by Gene Expression Signatures in Dermal Lymphatic Endothelial Cells in Type 2 Diabetes

High-Glucose Environment Enhanced Oxidative Stress and Increased Interleukin-8 Secretion From Keratinocytes: New Insights Into Impaired Diabetic Wound Healing

Concentrations of Insulin Glargine and Its Metabolites During Long-Term Insulin Therapy in Type 2 Diabetic Patients and Comparison of Effects of Insulin Glargine, Its Metabolites, IGF-I, and Human Insulin on Insulin and IGF-I Receptor Signaling

Complications

A Novel Mechanism by Which SDF-1β Protects Cardiac Cells From Palmitate-Induced Endoplasmic Reticulum Stress and Apoptosis via CXCR7 and AMPK/p38 MAPK-Mediated Interleukin-6 Generation

Regulation of Matrix Metalloproteinase-9 by Epigenetic Modifications and the Development of Diabetic Retinopathy

Topical Administration of Somatostatin Prevents Retinal Neurodegeneration in Experimental Diabetes

Blocking Interleukin-1β Induces a Healing-Associated Wound Macrophage Phenotype and Improves Healing in Type 2 Diabetes

Pharmacology and Therapeutics

Topical Administration of Allogeneic Mesenchymal Stromal Cells Seeded in a Collagen Scaffold Augments Wound Healing and Increases Angiogenesis in the Diabetic Rabbit Ulcer

Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors

Genetics/Genomes/Proteomics/Metabolomics

From Single Nucleotide Polymorphism to Transcriptional Mechanism: A Model for FRMD3 in Diabetic Nephropathy

TCF7L2 Variation and Proliferative Diabetic Retinopathy

Next Generation Sequencing Reveals the Association of DRB3*02:02 With Type 1 Diabetes

Erratum

The peri-islet basement membrane, a barrier to infiltrating leukocytes in type 1 diabetes in mouse and human. Diabetes 2013;62:531–542

Issues and Events

Issues and Events

Diabetes Digests

Highlights From the Latest in Diabetes Research

Online Letters to the Editor

Comment on: Takeda et al. Loss of ACE2 Exaggerates High-Calorie Diet–Induced Insulin Resistance by Reduction of GLUT4 in Mice. Diabetes 2013;62:223–233

Response to Comment on: Takeda et al. Loss of ACE2 Exaggerates High-Calorie Diet–Induced Insulin Resistance by Reduction of GLUT4 in Mice. Diabetes 2013;62:223–233

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Hyperglycemia-Induced Protein Kinase C β₂ Activation Induces Diastolic Cardiac Dysfunction in Diabetic Rats by Impairing Caveolin-3 Expression and Akt/eNOS Signaling