Nature Reviews Gastroenterology & Hepatology
(NAT REV GASTRO HEPAT) 《自然评论:肠胃与肝病学》
Clostridium difficile: Restoring the balance—microbes for the management ofClostridium difficile infection? | PDF (215 KB)
p381 | doi:10.1038/nrgastro.2013.109
Infection: Modelling persistent giardiasis and malnutrition | PDF (204 KB)
p382 | doi:10.1038/nrgastro.2013.100
Barrett oesophagus: Using length of Barrett oesophagus to determine risk of progression to high-grade dysplasia and adenocarcinoma | PDF (194 KB)
p383 | doi:10.1038/nrgastro.2013.103
Endoscopy: New molecular probe for targeted imaging of oesophageal neoplasia in Barrett oesophagus | PDF (117 KB)
p383 | doi:10.1038/nrgastro.2013.95
Alcoholic liver disease: ASMase implicated in alcoholic liver disease | PDF (94 KB)
p384 | doi:10.1038/nrgastro.2013.104
Diarrhoea: Tackling the problem of moderate-to-severe diarrhoea in developing countries | PDF (57 KB)
p384 | doi:10.1038/nrgastro.2013.98
Viral hepatitis: New advances in IL28B genetics | PDF (48 KB)
p385 | doi:10.1038/nrgastro.2013.102
IBD: Golimumab shows promise in treatment of active ulcerative colitis | PDF (53 KB)
p386 | doi:10.1038/nrgastro.2013.108
GERD: Alginate rafts localize to the acid pocket and reduce acid reflux in GERD | PDF (87 KB)
p386 | doi:10.1038/nrgastro.2013.97
IBD: Trichuris suis ova–safety and tolerability as a new treatment option for patients with Crohn's disease? | PDF (46 KB)
p382 | doi:10.1038/nrgastro.2013.110
Endoscopy: Promising tool for targeted delivery of drugs to the gastrointestinal tract | PDF (46 KB)
p382 | doi:10.1038/nrgastro.2013.111
Diarrhoea: Zinc supplementation reduces diarrhoea-asssociated morbidity in young infants | PDF (46 KB)
p382 | doi:10.1038/nrgastro.2013.112
NEWS AND VIEWS
Liver: Links between hepatobiliary diseases in and beyond pregnancy
Lucy C. Chappell & Catherine Williamson
p387 | doi:10.1038/nrgastro.2013.92
New data from a large cohort study describe an increased risk of intrahepatic cholestasis of pregnancy (ICP) in women with prior hepatobiliary disease and confirm the association between ICP and subsequent disease. These findings should prompt a change in clinical practice for guidelines to recommend hepatitis C screening for women with ICP.
Barrett oesophagus: Is RFA the overall answer to all Barrett oesophagus issues?
Michael Vieth & Helmut Neumann
p388 | doi:10.1038/nrgastro.2013.75
After endoscopic resection of Barrett neoplasia, complete ablation of the remaining Barrett segment is thought to reduce the risk of relapse. Little is known about the long-term outcome of radiofrequency ablation (RFA) after prior endoscopic resection of Barrett neoplasia. The use of RFA in nondysplastic Barrett oesophagus is receiving increasing levels of criticism.
Liver: How can acute-on-chronic liver failure be accurately identified?
Fu-Sheng Wang & Zheng Zhang
p390 | doi:10.1038/nrgastro.2013.72
Acute-on-chronic liver failure (ACLF) is a unique clinical entity that causes confusion amongst clinicians because no clear definition or standardized clinical features have been agreed worldwide. A recent comprehensive study provided an evidence-based definition and addressed its clinical features in patients with ACLF who have cirrhosis with acute decompensation.
Colorectal cancer: Is the new era of colorectal cancer classification finally here?
Iris D. Nagtegaal & J. Han J. M. van Krieken
p391 | doi:10.1038/nrgastro.2013.90
Colorectal cancer is a heterogeneous disease, with at least three well-known major, molecularly defined groups: the chromosomal instable, the microsatellite instable and the CpG island methylator phenotype. Although these groups differ in pathology, outcome and response to therapy, this classification is not used in clinical management. Two recent studies might change this perception.
Autophagy: a new target or an old strategy for the treatment of Crohn's disease?
Kris Nys, Patrizia Agostinis & Séverine Vermeire
p395 | doi:10.1038/nrgastro.2013.66
Nys et al. discuss the emerging role of autophagy as a regula-tor of immune and/or inflammatory responses and as a stress adaptive mechanism, and analyze its value as a diagnostic and/or therapeutic target in Crohn's disease. Moreover, they highlight how several drugs used in the treatment of Crohn's disease have already been shown to affect autophagy induction as part of their mode of action.
Management of varices in patients with cirrhosis
Julia O'Brien, Christos Triantos & Andrew K. Burroughs
p402 | doi:10.1038/nrgastro.2013.51
Variceal bleeding is a life-threatening condition. Here the au-thors summarize recent clinical findings and present the most updated advances on the management of gastro-oesophageal varices and variceal bleeding.
State-of-the-art medical prevention of postoperative recurrence of Crohn's disease
p413 | doi:10.1038/nrgastro.2013.69
Postoperative recurrence (POR) frequently occurs in patients with Crohn's disease, but current medications have proven of little benefit for this indication. In this Review, Dario Sorrentino outlines the definition, the main modalities of diagnosis and the risk factors for POR. The various medications and approaches used to prevent POR are also discussed and an algorithm for prevention of POR is proposed.
New insights into pancreatic cancer-induced paraneoplastic diabetes
Raghuwansh P. Sah, Sajan Jiv Singh Nagpal, Debabrata Mukhopadhyay & Suresh T. Chari
p423 | doi:10.1038/nrgastro.2013.49
The authors present the emerging evidence that pancreatic cancer causes diabetes and associated weight loss. The emerging concepts in the pathogenesis of these metabolic changes are also discussed as well as the potential for the discovery of biomarkers for the early diagnosis of pancreatic cancer.
Liver transplantation: past, present and future
Ali Zarrinpar & Ronald W. Busuttil
p434 | doi:10.1038/nrgastro.2013.88
Liver transplantation has progressed from an experimental procedure to routine operation since the first human liver transplantation in 1963. This Timeline article revisits the important milestones in the development of liver transplantation, discussing how the procedure has evolved over time and what challenges are still to overcome.